As Britain stands alone against a monstrous enemy, the inhabitants of Pearl Street face hardship and heartbreak with courage and humour. The war touches each of them in a different way: for Annie Poulson, a widow, it means never-ending worry when her twin boys are called up and sent to France; Sheila Reilly's husband, Cal, faces the terror of U-Boat attacks; Eileen Costello is liberated from a bitter, loveless marriage when her husband is sent to Egypt.

Following the disastrous retreat of the British army from Dunkirk in 1940, England is plunged into a state of fear. The threat of a German invasion is real, and many German Nationals are interned in camps across the country. One such camp is on the ancient moor land of Prees Heath, near the small town of Whitchurch in Shropshire, where Tom Tyler is the sole detective inspector. Young women from all walks of life have joined the Land Army, to help desperate farmers keep the country fed. Then one turns up dead.

In the summer of 1940, ambitious young American journalist Ruby Sutton gets her big break: the chance to report on the European war as a staff writer for Picture Weekly newsmagazine in London. She jumps at the chance, for it's an opportunity not only to prove herself, but also to start fresh in a city and country that know nothing of her humble origins. But life in besieged Britain tests Ruby in ways she never imagined.

East London, 1888 - a city apart. A place of shadow and light where thieves, whores, and dreamers mingle, where children play in the cobbled streets by day and a killer stalks at night, where bright hopes meet the darkest truths. Here, by the whispering waters of the Thames, Fiona Finnegan, a worker in a tea factory, hopes to own a shop one day, together with her lifelong love, Joe Bristow, a costermonger's son. With nothing but their faith in each other to spur them on, Fiona and Joe struggle, save, and sacrifice to achieve their dreams.

Autumn 1928. Three young women are on their way to India, each with a new life in mind. Rose, a beautiful but naive bride-to-be, is anxious about leaving her family and marrying a man she hardly knows. Victoria, her bridesmaid couldn't be happier to get away from her overbearing mother, and is determined to find herself a husband. And Viva, their inexperienced chaperone, is in search of the India of her childhood, ghosts from the past and freedom.

Liverpool, 1941. Troubled by a dark family history and the pain of seeing her country torn apart by war, young June Lavender finds new hope when she takes a job at the Dr Barnardo's children's home. There she meets Lizzie McRae, a little girl who is the spitting image of June's sister, who died tragically years before. Against the matron's wishes, the two girls form an unexpected bond as June tries to get the traumatised orphan to speak.

At the age of 22, Jennifer Worth left her comfortable home to move into a convent and become a midwife in postwar London’s East End slums. The colorful characters she met while delivering babies all over London - from the plucky, warm-hearted nuns with whom she lived to the woman with 24 children who couldn't speak English to the prostitutes and dockers of the city’s seedier side - illuminate a fascinating time in history.

It’s the summer of 1919, and Ellen O’Brien has her whole life ahead of her. Young, in love and leaving home for her first job, the future seems full of shining possibility. But war is brewing, and before long, Ellen and everyone around her are swept up by it. As Ireland is torn apart by the turmoil, Ellen finds herself facing the ultimate test of love and loyalty. A hundred years later and Clare Farrell has inherited a dilapidated old farmhouse in County Meath.

Mary Doyle arrives in Dublin in 1913, doomed, she fears, to a life of domestic service. Instead, however, she finds herself deeply affected by the social and political turmoil of a fledgling nation struggling for independence. Suddenly, all that was once inevitable is no longer a certainty as she is embroiled in the very heart of the Easter Rising.

Three very different girls sign up as trainee nurses at a big London teaching hospital in 1934. Dora leaves her overcrowded, squalid working-class home for a better life. But has she got what it takes to keep up with other, better-educated girls? And will her hated stepfather ever let her go? Helen is born for the job; her brother is a doctor, her all-powerful mother a hospital trustee. But will Helen’s secret misery be her downfall? An aristocratic rebel, Millie’s carefree attitude will find her up in front of Matron again and again. Will she ever care enough to make a nurse? Or will she go back to the glamorous life she was born to?

Daughters of Eden focuses on the lives and fortunes of four very different young women at the outbreak of the Second World War. Marjorie, left at a boarding school by her emigrating mother; plain Poppy, pushed into marriage with a mean-spirited aristocrat; Kate, despised by her father, but determined to prove herself; and man-mad Lily, who turns out to be the bravest of them all. That all of them are chosen to work undercover for the espionage unit at Eden Park is a surprise, not least to them.

Alice Lake has arrived in London from Liverpool to start her training as a District Nurse, but her journey has been far from easy. Her parents think that she should settle down and get married, but she has already had her heart broken once and isn’t about to make the same mistake again. Alice and her best friend, Edith, are based in the East End, but before they’ve even got their smart new uniforms on, war breaks out, and Hitler’s bombs are raining down on London.

Liverpool, 1940. When her childhood sweetheart, Johnny, is killed in action, Maxine Grey loses more than her husband - she loses her best friend. Desperate to make a difference in this awful war, Maxine takes a nursing job at London’s St Thomas’ hospital. She takes comfort in the attentions of a handsome surgeon, but Edwin Blake isn’t all he seems. And as the Blitz descends on the capital, Maxine faces more heartache. When she returns to Liverpool, she harbours a secret.

When sixteen-year-old Sally is evacuated to the English south coast, she is terrified by what lies ahead of her. All she knows are the sights and sounds of London's East End – but Sally swallows her tears as they leave the familiar landmarks behind, knowing that she has to be a Grown-Up Girl and play mother to her six-year-old brother Ernie. Playing mother is nothing new for Sally – their real mother Florrie, a good-time girl, hasn't even come to the station to wave them off and Ernie, crippled at an early age by polio, is used to depending on his older sister.

Tusker and Lily Smalley stayed on in India. Given the chance to return ‘home’ when Tusker, once a Colonel in the British Army, retired, they chose instead to remain in the small hill town of Pankot, with its eccentric inhabitants and archaic rituals left over from the days of the Empire. Only the tyranny of their imposing landlady threatens to upset the quiet rhythm of their days.