Liverpool, 1868. Shrouded in secrecy, Alice Sampson gives birth to a beautiful baby girl. But the former nurse's happiness is blighted by the knowledge that as a penniless, unwed mother, her future, and that of her child, can only be one of shame and disgrace. Then a knock at the door brings a miracle: she is invited to return to the Liverpool Royal Infirmary and her beloved ward. With the help of her friends and the welcome attentions of Reverend Seed, the hospital Chaplain, Alice slowly starts to rebuild her life.

1918, London. Twenty-year-old Emily Burdon has been training as a nurse at St. Marylebone Infirmary, learning on the job as she tends to patients from the crowded poorhouses that ring the hospital as well as wounded soldiers returning from the war. She pours her heart into her nursing while she waits for happier times - peace in Europe and the return of her childhood sweetheart, Lewis, from the Western Front. But when the deadly Spanish Flu arrives in London on the heels of the war, Emily’s faith and courage are put to the test.

England, 1941. After three nights of relentless bombing from German aircraft, trained nurse Jo Brooks is told to report to the basement theater of Mill Road Hospital. She goes with a heavy heart, not wanting to leave behind her best friend Moira, who is desperately soothing new mothers on the maternity ward. As Jo arrives safely underground, the ward takes a direct hit.

At 11, Pip Mackenzie's young life has already been touched by tragedy; nine months before, a terrible accident plunged her mother into inconsolable grief. But on this chilly July afternoon, Pip meets someone who fills her sad, gray world with color and light. And in her innocence and in his kindness, a spark will be kindled, lives will be changed, and a journey of hope will begin.

Preston and Constance Whittier have built a happy life together, with a brood of six children raised in a beautiful historic Manhattan mansion. Now, with a nearly empty nest, it’s easier than ever for the Whittiers to maintain their tradition of a solo romantic “Wintermoon” ski trip. But with this year’s trip comes tragedy, and suddenly the Whittier’s adult children find themselves reuniting in the family home without their parents for the first time ever. The eldest four are forced to put aside their personal issues and their grief to keep the family together.

At the age of 22, Jennifer Worth left her comfortable home to move into a convent and become a midwife in postwar London’s East End slums. The colorful characters she met while delivering babies all over London - from the plucky, warm-hearted nuns with whom she lived to the woman with 24 children who couldn't speak English to the prostitutes and dockers of the city’s seedier side - illuminate a fascinating time in history.

Thirteen-year-old Lisa has escaped from Nazi Germany on the Kindertransport. She arrives in London unable to speak a word of English, her few belongings crammed into a small suitcase. Among them is one precious photograph of the family she has left behind. Lonely and homesick, she is adopted by a childless couple. But when the Blitz blows her new home apart, she wakes up in a hospital with no memory of who she is or where she came from. The authorities give her a new name and dispatch her to a children's home. With the war raging around her, what will become of Lisa now?

Bristol 1939. At forty years of age, Mary Anne Randall still turns heads. With an abusive husband spending most of his wages on beer, she has resigned herself to be the sole breadwinner to protect her family and keep the wolves from the door. In order to make ends meet, Mary Anne runs a pawnbroking business from the wash house at the end of the garden. Following the outbreak of war an opportunity presents itself to escape her loveless marriage and find true love. Will she take that chance, or carry on living just for her children and not for herself?

Caroline Payne thinks it’s just another day of work until she receives a call from Mat Hammond, an old college friend and historian. But pleasantries are cut short. Mat has uncovered a scandalous secret kept buried for decades: In World War II, Caroline’s British great-aunt betrayed family and country to marry her German lover. Determined to find answers and save her family’s reputation, Caroline flies to her family’s ancestral home in London.

Ginny Carter was once a rising star in TV news, married to a top anchorman, with a three-year-old son and a full and happy life in Beverly Hills - until her whole world dissolved in a single instant on the freeway two days before Christmas. In the aftermath, she pieces her life back together and tries to find meaning in her existence as a human rights worker in the worst areas around the globe.

Ana Kaminski is pushed through the iron gates of Auschwitz beside her frightened young friend Ester Pasternak. As they reach the front of the line, Ana steps forward and quietly declares herself a midwife--and Ester her assistant. Their arms are tattooed and they’re ordered to the maternity hut. Holding an innocent newborn baby, Ana knows the fate of so many are in her hands and vows to do everything she can to save them.

Marion and Shiva Stone are twin brothers born of a secret union between a beautiful Indian nun and a brash British surgeon. Orphaned by their mother’s death and their father’s disappearance, bound together by a preternatural connection and a shared fascination with medicine, the twins come of age as Ethiopia hovers on the brink of revolution.

London 1940. As the war rages in Europe, Rose Brown steps on board a ship bound for America, hoping to escape the danger. She's frightened, but her widowed mammy and three sisters in Ireland need the money she earns as nanny to the rich Townsend family. But while Rose plays with baby Sarah in the salty spray on deck, disaster strikes, and the ocean liner begins to sink. In the chaos, Rose and the baby are separated from the family.

West Yorkshire, 1926. After completing her training in Steeple Street, Agnes is looking forward to making her mark as the village's first district nurse, confident she can make a difference in the locals' lives. But when she arrives, she's treated with suspicion, labelled just another servant of the wealthy mine owners. The locals would much rather place their trust in the resident healer, Nella Black.

Occupied France, 1940. When the staff at a field hospital draw straws to find out who will join the evacuation from Dunkirk, Nurse Cate is left behind. But when the Nazis arrive to claim prisoners of war, she takes her chance and flees into the night, taking one patient with her. Fifty miles away, the surrendering soldiers of the Royal Norfolk Regiment are shot dead by the advancing Germans. Beneath the pile of bodies two men survive, crawling to the safety of a nearby farmhouse, where sisters Elise and Adelaide risk their lives to take them in.

East London, 1888 - a city apart. A place of shadow and light where thieves, whores, and dreamers mingle, where children play in the cobbled streets by day and a killer stalks at night, where bright hopes meet the darkest truths. Here, by the whispering waters of the Thames, Fiona Finnegan, a worker in a tea factory, hopes to own a shop one day, together with her lifelong love, Joe Bristow, a costermonger's son. With nothing but their faith in each other to spur them on, Fiona and Joe struggle, save, and sacrifice to achieve their dreams.

Lady Sophronia Bremerton is a far cry from the typical debutante, but she’s the toast of London’s upper class for one simple reason: she’s a society columnist for the London Illustrated News, and the gentry loves seeing their exploits printed in the gossip pages. But Sophie has bigger plans - she aspires to be an investigative reporter. When a stuffy ballroom during yet another Season proves to be nothing more than the usual rumor mill, Sophie seeks respite in the library, alongside four other young women who, for their own reasons, are also looking for escape.

It is Warsaw, 1939, and Elzunia is an indulged teenager who longs for a heroic life filled with romance. But the outbreak of war shatters all her dreams. As bombs fall, she meets Adam, a taciturn airman whose fate becomes entwined with hers. In despair over the occupation, Adam joins the Polish resistance, then flies bombers for the RAF.

Alice Lake has arrived in London from Liverpool to start her training as a District Nurse, but her journey has been far from easy. Her parents think that she should settle down and get married, but she has already had her heart broken once and isn’t about to make the same mistake again. Alice and her best friend, Edith, are based in the East End, but before they’ve even got their smart new uniforms on, war breaks out, and Hitler’s bombs are raining down on London.

Three very different girls sign up as trainee nurses at a big London teaching hospital in 1934. Dora leaves her overcrowded, squalid working-class home for a better life. But has she got what it takes to keep up with other, better-educated girls? And will her hated stepfather ever let her go? Helen is born for the job; her brother is a doctor, her all-powerful mother a hospital trustee. But will Helen’s secret misery be her downfall? An aristocratic rebel, Millie’s carefree attitude will find her up in front of Matron again and again. Will she ever care enough to make a nurse? Or will she go back to the glamorous life she was born to?

Welcome to the district nurses' home on Steeple Street, where everyone has a secret.... Ambitious young nurse Agnes Sheridan had a promising future ahead of her until a tragic mistake cost her the love and respect of everyone around her. Now she has come to Leeds for a fresh start as a trainee district nurse. But Agnes finds herself facing unexpected challenges as she is assigned to Quarry Hill, one of the city's most notorious slums.

Wrongfully accused of murder, Dr. Catherine Bennett is destined to hang...unless she can disappear. With the untamed territory of Colorado as her most likely refuge, she packs her physician's kit and heads West. But even with a new life and name, a female doctor with a bounty on her head can hide for only so long.

In the spring of 1914, a group of young students gather in an art studio for a life-drawing class. Paul Tarrant and Elinor Brooke are two components of a love triangle, and at the outset of the war, they turn to each other. After volunteering for the Red Cross, Paul must confront the fact that life, love, and art will never be the same for him.

Isolated on an island where two rivers meet, the Lazaretto quarantine hospital is the first stop for immigrants who wish to begin new lives in Philadelphia. The Lazaretto's black live-in staff forge a strong social community, and when one of them receives permission to get married on the island the mood is one of celebration, particularly since the white staff - save the opium-addicted doctor - are given leave for the weekend.

At the age of 22, Jennifer Worth left her comfortable home to move into a convent and become a midwife in postwar London’s East End slums. The colorful characters she met while delivering babies all over London - from the plucky, warm-hearted nuns with whom she lived to the woman with 24 children who couldn't speak English to the prostitutes and dockers of the city’s seedier side - illuminate a fascinating time in history.

Amsterdam 1654: a dangerous secret threatens to destroy a young widow's new life. Following the sudden death of her husband, 25-year-old Catrin leaves her small village and takes a job as housekeeper to the successful Van Nulandt merchant family. Amsterdam is a city at the peak of its powers: science and art are flourishing, and Dutch ships bring back exotic riches from the Far East. When a figure from her past threatens her new life, Catrin flees to Delft. There, her painting talent earns her a chance as a pottery painter.

When sixteen-year-old Sally is evacuated to the English south coast, she is terrified by what lies ahead of her. All she knows are the sights and sounds of London's East End – but Sally swallows her tears as they leave the familiar landmarks behind, knowing that she has to be a Grown-Up Girl and play mother to her six-year-old brother Ernie. Playing mother is nothing new for Sally – their real mother Florrie, a good-time girl, hasn't even come to the station to wave them off and Ernie, crippled at an early age by polio, is used to depending on his older sister.

Life as a ship's boy aboard HMS Dolphin is a dream come true for Jacky Faber. Gone are the days of scavenging for food and fighting for survival on the streets of 18th-century London. Instead, Jacky is becoming a skilled and respected sailor as the crew pursues pirates on the high seas. There's only one problem: Jacky is a girl. And she will have to use every bit of her spirit, wit, and courage to keep the crew from discovering her secret.

Struggling alone on the family farm, Abigail Tidwell knows exactly who to blame for her hardships: the Americans. If it weren't for their part in the war, her father and brothers would be home rather than fighting abroad. But no amount of antipathy could have prepared her for the shocking sight of a wounded American soldier on her property, a man in dire need of her help. Grudgingly, Abigail tends to the soldier's injuries and anticipates the satisfaction of turning him over to the authorities once he is healed. But fate has other plans.

The global fiction sensation - published in 32 countries around the world: Meet Doris, a 96-year-old woman living alone in her Stockholm apartment. She has few visitors, but her weekly Skype calls with Jenny - her American grandniece, and her only relative - give her great joy and remind her of her own youth. In writing down the stories of her colorful past - working as a maid in Sweden, modelling in Paris during the '30s, fleeing to Manhattan at the dawn of the Second World War - she may help Jenny, haunted by a difficult childhood, unlock the secrets of their family....