Liverpool, 1868. Shrouded in secrecy, Alice Sampson gives birth to a beautiful baby girl. But the former nurse's happiness is blighted by the knowledge that as a penniless, unwed mother, her future, and that of her child, can only be one of shame and disgrace. Then a knock at the door brings a miracle: she is invited to return to the Liverpool Royal Infirmary and her beloved ward. With the help of her friends and the welcome attentions of Reverend Seed, the hospital Chaplain, Alice slowly starts to rebuild her life.

1918, London. Twenty-year-old Emily Burdon has been training as a nurse at St. Marylebone Infirmary, learning on the job as she tends to patients from the crowded poorhouses that ring the hospital as well as wounded soldiers returning from the war. She pours her heart into her nursing while she waits for happier times - peace in Europe and the return of her childhood sweetheart, Lewis, from the Western Front. But when the deadly Spanish Flu arrives in London on the heels of the war, Emily’s faith and courage are put to the test.

England, 1941. After three nights of relentless bombing from German aircraft, trained nurse Jo Brooks is told to report to the basement theater of Mill Road Hospital. She goes with a heavy heart, not wanting to leave behind her best friend Moira, who is desperately soothing new mothers on the maternity ward. As Jo arrives safely underground, the ward takes a direct hit.

At 11, Pip Mackenzie's young life has already been touched by tragedy; nine months before, a terrible accident plunged her mother into inconsolable grief. But on this chilly July afternoon, Pip meets someone who fills her sad, gray world with color and light. And in her innocence and in his kindness, a spark will be kindled, lives will be changed, and a journey of hope will begin.

Preston and Constance Whittier have built a happy life together, with a brood of six children raised in a beautiful historic Manhattan mansion. Now, with a nearly empty nest, it’s easier than ever for the Whittiers to maintain their tradition of a solo romantic “Wintermoon” ski trip. But with this year’s trip comes tragedy, and suddenly the Whittier’s adult children find themselves reuniting in the family home without their parents for the first time ever. The eldest four are forced to put aside their personal issues and their grief to keep the family together.

At the age of 22, Jennifer Worth left her comfortable home to move into a convent and become a midwife in postwar London’s East End slums. The colorful characters she met while delivering babies all over London - from the plucky, warm-hearted nuns with whom she lived to the woman with 24 children who couldn't speak English to the prostitutes and dockers of the city’s seedier side - illuminate a fascinating time in history.

Thirteen-year-old Lisa has escaped from Nazi Germany on the Kindertransport. She arrives in London unable to speak a word of English, her few belongings crammed into a small suitcase. Among them is one precious photograph of the family she has left behind. Lonely and homesick, she is adopted by a childless couple. But when the Blitz blows her new home apart, she wakes up in a hospital with no memory of who she is or where she came from. The authorities give her a new name and dispatch her to a children's home. With the war raging around her, what will become of Lisa now?

Bristol 1939. At forty years of age, Mary Anne Randall still turns heads. With an abusive husband spending most of his wages on beer, she has resigned herself to be the sole breadwinner to protect her family and keep the wolves from the door. In order to make ends meet, Mary Anne runs a pawnbroking business from the wash house at the end of the garden. Following the outbreak of war an opportunity presents itself to escape her loveless marriage and find true love. Will she take that chance, or carry on living just for her children and not for herself?

In April 1942, Lale Sokolov, a Slovakian Jew, is forcibly transported to the concentration camps at Auschwitz-Birkenau. When his captors discover that he speaks several languages, he is put to work as a Tätowierer (German for tattooist), tasked with permanently marking his fellow prisoners. Imprisoned for more than two and a half years, Lale witnesses horrific atrocities and barbarism - but also incredible acts of bravery and compassion. Risking his own life, he uses his position to exchange jewels and money from murdered Jews for food to keep his fellow prisoners alive.

Caroline Payne thinks it’s just another day of work until she receives a call from Mat Hammond, an old college friend and historian. But pleasantries are cut short. Mat has uncovered a scandalous secret kept buried for decades: In World War II, Caroline’s British great-aunt betrayed family and country to marry her German lover. Determined to find answers and save her family’s reputation, Caroline flies to her family’s ancestral home in London.

In the slums of 1880s New York, Una Kelly has grown up to be a rough-and-tumble grifter, able to filch a pocketbook in five seconds flat. But when another con-woman pins her for a murder she didn't commit, Una is forced to flee. Running from the police, Una lies her way into an unlikely refuge: the nursing school at Bellevue Hospital.

Ana Kaminski is pushed through the iron gates of Auschwitz beside her frightened young friend Ester Pasternak. As they reach the front of the line, Ana steps forward and quietly declares herself a midwife--and Ester her assistant. Their arms are tattooed and they’re ordered to the maternity hut. Holding an innocent newborn baby, Ana knows the fate of so many are in her hands and vows to do everything she can to save them.

Marion and Shiva Stone are twin brothers born of a secret union between a beautiful Indian nun and a brash British surgeon. Orphaned by their mother’s death and their father’s disappearance, bound together by a preternatural connection and a shared fascination with medicine, the twins come of age as Ethiopia hovers on the brink of revolution.

London 1940. As the war rages in Europe, Rose Brown steps on board a ship bound for America, hoping to escape the danger. She's frightened, but her widowed mammy and three sisters in Ireland need the money she earns as nanny to the rich Townsend family. But while Rose plays with baby Sarah in the salty spray on deck, disaster strikes, and the ocean liner begins to sink. In the chaos, Rose and the baby are separated from the family.

In the spring of 1628, the Witchfinder of Wessex finds himself a true Witch. As Bess Hawksmith watches her mother swing from the Hanging Tree she knows that only one man can save her from the same fate at the hands of the panicked mob: the Warlock Gideon Masters, and his Book of Shadows. Secluded at his cottage in the woods, Gideon instructs Bess in the Craft, awakening formidable powers she didn’t know she had and making her immortal. She couldn't have foreseen that even now, centuries later, he would be hunting her across time, determined to claim payment for saving her life.