Harry Cliff - a University of Cambridge particle physicist and researcher on the Large Hadron Collider - sets out in pursuit of answers. He ventures to the largest underground research facility in the world, deep beneath Italy's Gran Sasso mountains, where scientists gaze into the heart of the Sun using the most elusive of particles, the ghostly neutrino. He visits CERN in Switzerland to explore the "Antimatter Factory," where the stuff of science fiction is manufactured daily (and we're close to knowing whether it falls up).

In this fascinating and thought-provoking book, author Nick Lane brings together the latest research findings in the exciting field of mitochondria research to reveal how our growing understanding of mitochondria is shedding light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. This understanding is of fundamental importance, both in understanding how we and all other complex life came to be, but also in order to be able to control our own illnesses, and delay our degeneration and death.

For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight-how the same simple chemistry gives rise to life and causes our demise.

For particularly brilliant theoretical physicists like James Clerk Maxwell, Paul Dirac, or Albert Einstein, the search for mathematical truths led to strange new understandings of the ultimate nature of reality. But what are these truths? What are the mysterious numbers that explain the universe? In Fantastic Numbers and Where to Find Them, the leading theoretical physicist and YouTube star Antonio Padilla takes us on an irreverent cosmic tour of nine of the most extraordinary numbers in physics, offering a startling picture of how the universe works.

Where does DNA come from? What is consciousness? How did the eye evolve? Drawing on a treasure trove of new scientific knowledge, Nick Lane expertly reconstructs evolution's history by describing its 10 greatest inventions - from sex and warmth to death - resulting in a stunning account of nature's ingenuity.

How did a simple commodity, once the prized monopoly of kings and princes, become an essential ingredient in the lives of millions, before mutating yet again into the cause of a global health epidemic? Prior to 1600, sugar was a costly luxury, the domain of the rich. But with the rise of the sugar colonies in the New World over the following century, sugar became cheap, ubiquitous, and an everyday necessity. Less than 50 years ago, few people suggested that sugar posed a global health problem.

In the early 17th century, Galileo broke free from the hold of ancient Platonic and Aristotelian philosophy. He drastically changed the framework through which we view the natural world when he asserted that we should base our theory of reality on what we can observe rather than pure thought. In the process, he invented what we would come to call science. This set the stage for all the breakthroughs that followed - from Kepler to Newton to Einstein.

Elegantly written and deeply grounded in personal experience - works by Oliver Sacks come to mind - Physical Intelligence gives us a clear, illuminating examination of the intricate, mutually responsive relationship between the mind and the body as they engage (or don’t engage) in all manner of physical action. Ever wonder why you don’t walk into walls or off cliffs? How you decide if you can drive through a snowstorm? How high you are willing to climb up a ladder to change a lightbulb?

With stories that entertain as much as they inform, renowned evolutionist David Sloan Wilson outlines the basic principles of evolution and shows how, when properly understood, they can illuminate the length and breadth of creation, from the origin of life to the nature of religion.

Insects might make us recoil in repugnance, but they also manufacture - or make possible in other ways - many of the things we take for granted in our daily lives. When we bite into a shiny apple, listen to the resonant notes of a violin, try on the latest fashions, receive a dental implant, or get a manicure, we are mingling with the by-products of their everyday lives.

Who wore the first pants? Who painted the first masterpiece? Who first rode the horse? Who invented soap? This madcap adventure across ancient history uses everything from modern genetics to archaeology to uncover the geniuses behind these and other world-changing innovations. With a sharp sense of humor and boundless enthusiasm for the wonders of our ancient ancestors, Who Ate the First Oyster? profiles the perpetrators of the greatest firsts and catastrophes of prehistory.

With a lifetime of experience, profound knowledge and understanding, and heartwarming appreciation, an internationally celebrated conductor and teacher answers the questions: Why should I listen to classical music? How can I get the most from the listening experience? Unpretentious, graceful, instructive, this is a book for the aficionado, the novice, and anyone looking to have the love of music fired within them.

Just over 125,000 years ago, humanity was going extinct until a dramatic shift occurred—Homo sapiens started tracking the tides in order to eat the nearby oysters. Before long, they’d pulled themselves back from the brink of extinction. The human brain, and its evolutionary journey, is unlike anything else in history. In A History of the Human Brain, Bret Stetka takes listeners through that far-reaching journey. He also tackles the question of where the brain will take us next, exploring the burgeoning con­cepts of epigenetics and new technologies like CRISPR.

The cells in our bodies consist of molecules, made up of the same carbon, oxygen, and hydrogen atoms found in air and rocks. But molecules, such as water and sugar, are not alive. So how do our cells - assemblies of otherwise "dead" molecules - come to life, and together constitute a living being? In Life’s Ratchet, physicist Peter M. Hoffmann locates the answer to this age-old question at the nanoscale.

When celebrated neuropsychologist Paul Broks' wife died of cancer, it sparked a journey of grief and reflection that traced a lifelong attempt to understand how the brain gives rise to the soul. The result of that journey is a gorgeous, evocative meditation on fate, death, consciousness, and what it means to be human. The Darker the Night, the Brighter the Stars weaves a scientist’s understanding of the mind - its logic, its nuance, how we think about what makes a person - with a poet’s approach to humanity, that crucial and ever-elusive why.

The Earth teems with life: in its oceans, forests, skies, and cities. Yet there's a black hole at the heart of biology. We do not know why complex life is the way it is, or, for that matter, how life first began. In The Vital Question, award-winning author and biochemist Nick Lane radically reframes evolutionary history, putting forward a solution to conundrums that have puzzled generations of scientists.

Paul Falkowski looks "under the hood" of microbes to find the engines of life, the actual working parts that do the biochemical heavy lifting for every living organism on Earth. With insight and humor, he explains how these miniature engines are built - and how they have been appropriated by and assembled like Lego sets within every creature that walks, swims, or flies. Falkowski shows how evolution works to maintain this core machinery of life, and how we and other animals are veritable conglomerations of microbes.

Why is the world the way it is? How did we get here? Does everything happen for a reason, or are some things left to chance? Philosophers and theologians have pondered these questions for millennia, but startling scientific discoveries over the past half century are revealing that we live in a world driven by chance. A Series of Fortunate Events tells the story of the awesome power of chance and how it is the surprising source of all the beauty and diversity in the living world.

The essential guide to radiation: the good, the bad, and the utterly fascinating, explained with unprecedented clarity. Earth, born in a nuclear explosion, is a radioactive planet; without radiation, life would not exist. And while radiation can be dangerous, it is also deeply misunderstood and often mistakenly feared. Now Robert Peter Gale, M.D. - the doctor to whom concerned governments turned in the wake of the Chernobyl and Fukushima - in collaboration with medical writer Eric Lax draws on an exceptional depth of knowledge to correct myths and establish facts.

We humans like to think of ourselves as highly evolved creatures. But if we are supposedly evolution's greatest creation, why do we have such bad knees? Why do we catch head colds so often - 200 times more often than a dog does? How come our wrists have so many useless bones? And are we really supposed to swallow and breathe through the same narrow tube? Surely there's been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last.

Suddenly, research findings require a paradigm shift in our view of the microbial world. The Human Microbiome Project at the National Institutes of Health is well under way, and unprecedented scientific technology now allows the censusing of trillions of microbes inside and on our bodies as well as in the places where we live, work, and play. This intriguing, up-to-the-minute book for scientists and nonscientists alike explains what researchers are discovering about the microbe world and what the implications are for modern science and medicine.

Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way.

In Arrival of the Fittest, renowned evolutionary biologist Andreas Wagner draws on over 15 years of research to present the missing piece in Darwin's theory. Using experimental and computational technologies that were heretofore unimagined, he has found that adaptations are not just driven by chance, but by a set of laws that allow nature to discover new molecules and mechanisms in a fraction of the time that random variation would take.

The Nobel laureate Otto Warburg was widely regarded in his day as one of the most important biochemists of the 20th century, a man whose research was integral to humanity’s understanding of cancer. He was also among the most despised figures in Nazi Germany. As a Jewish homosexual living openly with his male partner, Warburg represented all that the Third Reich abhorred. Yet Hitler and his top advisors dreaded cancer, and protected Warburg in the hope that he could cure it.

This new book by Spencer Wells, the internationally known geneticist, anthropologist, author, and director of the Genographic Project, focuses on the seminal event in human history: mankind's decision to become farmers rather than hunter-gatherers.

You are just 10% human. For every one of the cells that make up the vessel that you call your body, there are nine impostor cells hitching a ride. You are not just flesh and blood, muscle and bone, brain and skin, but also bacteria and fungi. Over your lifetime, you will carry the equivalent weight of five African elephants in microbes. You are not an individual but a colony. Until recently, we had thought our microbes hardly mattered, but science is revealing a different story, one in which microbes run our bodies and becoming a healthy human is impossible without them.

Why are conditions like autism, asthma, obesity, and allergies exploding at unprecedented rates? Why are we living longer, getting smarter, having far fewer kids? If Darwin were alive today, how would he explain this new world?

When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way - an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease.

Where did I come from? Why do I have two arms but just one head? How is my left leg the same size as my right one? Why are the fingerprints of identical twins not identical? How did my brain learn to learn? Why must I die? Questions like these remain biology's deepest and most ancient challenges. They force us to confront a fundamental biological problem: How can something as large and complex as a human body organize itself from the simplicity of a fertilized egg?

A nutritional whodunit that takes readers from Greenland to Africa to Israel, The Queen of Fats gives a fascinating account of how we have become deficient in a nutrient that is essential for good health: the fatty acids know as omega-3s.

For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight-how the same simple chemistry gives rise to life and causes our demise.

In this fascinating and thought-provoking book, author Nick Lane brings together the latest research findings in the exciting field of mitochondria research to reveal how our growing understanding of mitochondria is shedding light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. This understanding is of fundamental importance, both in understanding how we and all other complex life came to be, but also in order to be able to control our own illnesses, and delay our degeneration and death.

Where does DNA come from? What is consciousness? How did the eye evolve? Drawing on a treasure trove of new scientific knowledge, Nick Lane expertly reconstructs evolution's history by describing its 10 greatest inventions - from sex and warmth to death - resulting in a stunning account of nature's ingenuity.

The Earth teems with life: in its oceans, forests, skies, and cities. Yet there's a black hole at the heart of biology. We do not know why complex life is the way it is, or, for that matter, how life first began. In The Vital Question, award-winning author and biochemist Nick Lane radically reframes evolutionary history, putting forward a solution to conundrums that have puzzled generations of scientists.

An enchanting biography of the most resonant - and most necessary - chemical element on Earth. Carbon. It's in the fibers in your hair, the timbers in your walls, the food that you eat, and the air that you breathe. It's worth billions as a luxury and half a trillion as a necessity, but there are still mysteries yet to be solved about the element that can be both diamond and coal. Where does it come from, what does it do, and why, above all, does life need it?

Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome - an enormous molecular machine made up of a million atoms - that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases.

The Story of the Earth in 25 Rocks tells the fascinating stories behind the discoveries that shook the foundations of geology. In 25 chapters, Donald R. Prothero recounts the scientific detective work that shaped our understanding of geology, from the unearthing of exemplary specimens to tectonic shifts in how we view the inner workings of our planet.

We all know that without water we couldn't survive, and that sometimes a cup of coffee or a glass of wine feels just as vital. But do we really understand how much we rely on liquids, or the destructive power they hold? Set over the course of a flight from London to San Francisco, Liquid Rules offers listeners a fascinating tour of these formless substances, told through the language of molecules, droplets, heartbeats, and ocean waves.

The theory of evolution unites the past, present, and future of living things. It puts humanity's place in the universe into necessary perspective. Despite a history of controversy, the evidence for evolution continues to accumulate as a result of many separate strands of incredible scientific sleuthing. In The Story of Evolution in 25 Discoveries, Donald R. Prothero explores the most fascinating breakthroughs in piecing together the evidence for evolution.

Earth evolves. From first atom to molecule, mineral to magma, granite crust to single cell to verdant living landscape, ours is a planet constantly in flux. In this radical new approach to Earth’s biography, senior Carnegie Institution researcher and national best-selling author Robert M. Hazen reveals how the co-evolution of the geosphere and biosphere - of rocks and living matter - has shaped our planet into the only one of its kind in the Solar System, if not the entire cosmos.