Anna Maria has only known life inside the Pietà, an orphanage for children born of prostitutes. But the girls of the Pietà are lucky in a sense: most babies born of their station were drowned in the city’s canals. And despite the strict rules, the girls are given singing and music lessons from an early age. The most promising musicians have the chance to escape the fate of the rest: forced marriage to anyone who will have them.

Griffin Hurt is in over his head. Between his role as Peter Proton on the hit TV show The Nuclear Family and the pressure of high school at New York's elite Boyd Prep—along with the increasingly compromising demands of his wrestling coach—he's teetering on the edge of collapse. Then comes Naomi Shah, twenty-two years Griffin’s senior. Unwilling to lay his burdens on his shrink—whom he shares with his father, mother, and younger brother, Oren—Griffin soon finds himself in the back of Naomi’s Mercedes sedan, again and again, confessing all to the one person who might do him the most harm.

Dominic Salt and his three children are caretakers of Shearwater, a tiny island not far from Antarctica. Home to the world’s largest seed bank, Shearwater was once full of researchers, but with sea levels rising, the Salts are now its final inhabitants. Until, during the worst storm the island has ever seen, a woman mysteriously washes ashore.

1348. As the Black Plague ravages Italy, Ginevra di Gasparo is summoned to Florence after nearly a decade of lonely exile. Ginevra has a gift—harnessing the hidden powers of gemstones, she can heal the sick. But when word spread of her unusual abilities, she was condemned as a witch and banished. Now the same men who expelled Ginevra are begging for her return.

Four lives are drawn together in a sweeping, panoramic new novel from Richard Powers, showcasing the Pulitzer Prize-winning author of The Overstory at the height of his skills. Twelve-year-old Evie Beaulieu sinks to the bottom of a swimming pool in Montreal strapped to one of the world’s first aqualungs. Ina Aroita grows up in naval bases across the Pacific with art as her only home. Two polar opposites at an elite Chicago high school bond over a three-thousand-year-old board game; Rafi Young will get lost in literature, while Todd Keane’s work will lead to a startling AI breakthrough.

Standing in the remote windswept moors of Northern England, Coldwell Hall is the perfect place to hide. For the past five years, Kate Furniss has maintained her professional mask so carefully that she almost believes she is the character she has created: Coldwell’s respectable housekeeper. It is the summer of 1911 that brings new faces above and below the stairs of Coldwell Hall—including the handsome and mysterious new footman, Jem Arden. Just as the house’s shuttered rooms open, so does Kate’s guarded heart to a love affair that is as intense as it is forbidden.

The London suburb of Croydon, 1964: Helen Hansford is unmarried and in her thirties. Something of a disappointment to her middle-class parents, she’s an art therapist at the Westbury Park psychiatric hospital, where she has been having a rebellious love affair with her colleague Gil, a dashing but married doctor. One spring afternoon they receive a call about a disturbance at a derelict, vine-covered Victorian house a few miles up the road. There the police find a mute, thirty-seven-year-old man called William Tapping, his hair and beard down to his waist.

Anthony Opoka and Florence Okori are coming of age in Uganda in the 1990s. Outstanding students, they believe in being good humans before they are kidnapped and forced into the fanatical Lord’s Resistance Army. In a legion of young recruits, no one gets closer than Anthony to powerful messianic warlord Joseph Kony and his darkest secrets. To stay sane as he spirals through chaos, Anthony clings to his childhood lessons about being a good human. Florence’s upbringing grounds her, too, helping her keep her dreams alive even as she’s pulled deeper into the insanity of Kony’s war.

Inti Flynn arrives in Scotland with her twin sister, Aggie, to lead a team of biologists tasked with reintroducing fourteen gray wolves into the remote Highlands. She hopes to heal not only the dying landscape, but Aggie, too, unmade by the terrible secrets that drove the sisters out of Alaska. Inti is not the woman she once was, either, changed by the harm she’s witnessed—inflicted by humans on both the wild and each other. Yet as the wolves surprise everyone by thriving, Inti begins to let her guard down, even opening herself up to the possibility of love.

Franny Stone has always been the kind of woman who is able to love but unable to stay. Leaving behind everything but her research gear, she arrives in Greenland with a singular purpose: to follow the last Arctic terns in the world on what might be their final migration to Antarctica. Franny talks her way onto a fishing boat, and she and the crew set sail, traveling ever further from shore and safety. But as Franny’s history begins to unspool - a passionate love affair, an absent family, a devastating crime - it becomes clear that she is chasing more than just the birds.