They say it’s always beautiful in Bethlam, Nevada. No place you’d rather live. The people are friendly, if a little nosy, and there’s no crime to speak of. Life is pretty perfect. But postal worker Hank Davies has started to suspect something is off in this idyllic little town. And he’s certain of that when he realizes the letters he’s been delivering are just blank pages. Hank isn’t the only one who’s noticed the oddities in Bethlam. One such person knocks on his window in the middle of the night, urging him to investigate his bedroom wall.

A murderer is on the loose on the streets of New York City: nicknamed the Doomsday Killer, he's claimed six victims in just two weeks, and the city is terrified. Even worse, the police are mystified: the victims have nothing in common, defying all profiling, and all that connects them is that each received a sick postcard in the mail before they died - a postcard that announced their date of death. In desperation, the FBI assigns the case to maverick agent Will Piper, once the most accomplished serial-killing expert in the bureau's history, now on a dissolute spiral to retirement.

Farley stands out among his Iñupiat neighbors in the Alaska village he calls home, both white and enormous, like the hungry polar bears that wander its streets. Jovial and a little hapless, he works as an investigator for a North Slope oil company, passing the long Arctic winters drinking whiskey with the village’s preacher and playing in the weekly poker game hosted by its matriarch and mayor. When his young daughter visits from thousands of miles away in Portland—where she lives with her mother, who despises him—a shocking moment of violence leaves her dead and Farley injured.

After Culloden, Iain MacGillivray was left for dead on Drumossie Moor. Wounded, his face brutally slashed, he survived only by pretending to be dead as the Redcoats patrolled the corpses of his Jacobite comrades. Six years later, with the clan chiefs routed and the Highlands subsumed into the British state, Iain lives a quiet life, working as a bookseller in Inverness. One day, after helping several of his regular customers, he notices a stranger lurking in the upper gallery of his shop, poring over his collection. But the man refuses to say what he's searching for.

A strange, glowing object lands in the forest. Tim is the only one who sees it. Venturing out to investigate, he discovers animals infected with a mysterious black growth. When he returns to his cabin, he realizes the horrifying truth: whatever disease the object brought to Earth, Tim has caught it too.