After being diagnosed in her early forties with metastatic melanoma - a "rapidly fatal" form of cancer - journalist and mother of two Mary Elizabeth Williams finds herself in a race against the clock. She takes a once-in-a-lifetime chance and joins a clinical trial for immunotherapy, a revolutionary drug regimen that trains the body to vanquish malignant cells. Astonishingly, her cancer disappears entirely in just a few weeks. But at the same time, her best friend embarks on a cancer journey of her own - with very different results.

By turns heartbreaking, hilarious, and utterly human, The House of God is a mesmerizing and provocative journey that takes us into the lives of Roy Basch and five of his fellow interns at the most renowned teaching hospital in the country.

In 1972, at the age of 21, John Callahan was involved in a car crash that severed his spine and made him a quadriplegic. A heavy drinker since the age of 12, the accident could have been the beginning of a downward spiral. Instead, it sparked a personal transformation. After extensive physical therapy, he was eventually able to grasp a pen in his right hand and make rudimentary drawings. By 1978, Callahan had sworn off drinking for good and begun to draw cartoons. Over the next three decades, Callahan would become one of the nation's most beloved cartoonists.

The inimitably witty David Rakoff, New York Times best-selling author of Don’t Get Too Comfortable, defends the commonsensical notion that you should always assume the worst, because you’ll never be disappointed. In this deeply funny (and, no kidding, wise and poignant) audiobook, Rakoff examines the realities of our sunny, gosh­ everyone-can-be-a-star contemporary culture and finds that, pretty much as a universal rule, the best is not yet to come, adversity will triumph, justice will not be served, and your dreams won’t come true.

Written by Deborah Ziegler, the mother of Brittany Maynard - a 29-year-old woman with a terminal brain tumor - this touching and beautiful memoir captures and celebrates her daughter's spirit and the mostly untold story of Brittany's last year of life as she chose her right to die with dignity, a journey that inspired millions.

A month before her death on May 20, 1989, Gilda Radner entered a Los Angeles recording studio to deliver what would be her final performance - this remarkable audio autobiography, in which she reveals the inspirational story of her struggle with cancer...a private, personal battle in which the humor and humanity that has touched millions became her most powerful weapon.

Shep Knacker has long saved for “The Afterlife”: an idyllic retreat to the Third World where his nest egg can last forever. Traffic jams on the Brooklyn-Queens Expressway will be replaced with “talking, thinking, seeing, and being” — and enough sleep. When he sells his business for a cool million dollars, his dream finally seems within reach. Yet his wife Glynis has concocted endless excuses why it’s never the right time to go.

Laurie Notaro has proved everyone wrong: she didn’t end up in rehab, prison, or cremated at a tender age. She just went gray. At past fifty, every hair’s root is a symbol of knowledge (she knows how to use a landline), experience (she rode in a car with no seat belts), and superpowers (a gray-haired lady can get away with anything). Though navigating midlife is initially upsetting—the cracking noises coming from her new old body, receiving regular junk mail from mortuaries—Laurie accepts it. And then some.

When Kristi stopped drinking, she started noticing things. Like when you give up a debilitating habit, it leaves a space, one that can’t easily be filled by mocktails or ice cream or sex or crafting. And when you cancel Rosé Season for yourself, you’re left with just summer, and that’s when you notice that the women around you are tanked - that alcohol is the oil in the motors that keeps them purring when they could be making other kinds of noise. In her sharp, incisive debut essay collection, Coulter reveals a portrait of a life in transition.

In the tradition of Roxane Gay’s Hunger, a searing, honest, and candid exploration of what it’s like to live as a fat man, from acclaimed journalist Tommy Tomlinson, who decided he had to change his life as he neared the age of 50 weighing in at 460 pounds.

As a daughter, mother, and friend, Mary Laura Philpott considered herself an “anxious optimist”—a natural worrier with a stubborn sense of good cheer. And while she didn’t really think she had any sort of magical protective powers, she believed in her heart that as long as she loved her people enough, she could keep them safe.

When Amy B. Scher was struck with undiagnosed late-stage, chronic Lyme disease, the best physicians in America labeled her condition incurable and potentially terminal. Deteriorating rapidly, she went on a search to save her own life - from the top experts in Los Angeles and the world-renowned Mayo Clinic in Minneapolis to a state-of-the-art hospital in Chicago. After exhausting all of her options in the US, she discovered a possible cure - but it was highly experimental, available only in India, and had as much of a probability of killing her as it did of curing her.

Delia Ephron had struggled through several years of heartbreak. She’d lost her sister, Nora, and then her husband, Jerry, both to cancer. Several months after Jerry’s death, she decided to make one small change in her life - she shut down his landline, which crashed her internet. She ended up in Verizon hell.

An exquisite memoir about how to live - and love - every day with "death in the room", from poet Nina Riggs, mother of two young sons and the direct descendant of Ralph Waldo Emerson, in the tradition of When Breath Becomes Air.

When Edward M. Hallowell was 11, a voice out of nowhere told him he should become a psychiatrist. A mental health professional of the time would have called this psychosis. But young Edward (Ned) took it in stride, despite not quite knowing what "psychiatrist" meant. With a psychotic father, an alcoholic mother, an abusive stepfather, and two so-called learning disabilities of his own, Ned was accustomed to unpredictable behaviour from those around him and to a mind he felt he couldn't always control.

When Amy B. Scher was struck with undiagnosed late-stage, chronic Lyme disease, the best physicians in America labeled her condition incurable and potentially terminal. Deteriorating rapidly, she went on a search to save her own life - from the top experts in Los Angeles and the world-renowned Mayo Clinic in Minneapolis to a state-of-the-art hospital in Chicago. After exhausting all of her options in the US, she discovered a possible cure - but it was highly experimental, available only in India, and had as much of a probability of killing her as it did of curing her.

When Edward M. Hallowell was 11, a voice out of nowhere told him he should become a psychiatrist. A mental health professional of the time would have called this psychosis. But young Edward (Ned) took it in stride, despite not quite knowing what "psychiatrist" meant. With a psychotic father, an alcoholic mother, an abusive stepfather, and two so-called learning disabilities of his own, Ned was accustomed to unpredictable behaviour from those around him and to a mind he felt he couldn't always control.

A hilarious and heartbreaking memoir-in-remedies by a self-described "professional soul-searcher" that details a journey of self-discovery through more than 160 tonics, seminars, regimens, and transformative therapies. With a voice that is at once intimate and hilarious, Megan captures the openness and honesty necessary for people to take a new path in life. Listeners will open the audiobook with curiosity about all the different healing therapies that Megan tries, but leave with a new understanding of themselves.

Mark Vonnegut set out in search of Eden with his VW bug, his girlfriend, his dog, and his ideals, but genetic predisposition and a whole lot of shit going down made him crazy in a culture that told him mental illness is a myth and schizophrenia is a sane response to an insane society. Describing his experiences during the late '60s and early '70s, Eden Express reveals how Mark went from being a recent college grad who was in love and living communally on a farm to having nervous breakdowns.

David Menasche lived for his work as a high school English teacher. His passion inspired his students, and between lessons on Shakespeare and sentence structure, he forged a unique bond with his kids, buoying them through personal struggles while sharing valuable life lessons.

Emma Forrest, a British journalist, was just 22 and living the fast life in New York City when she realized that her quirks had gone beyond eccentricity. In a cycle of loneliness, damaging relationships, and destructive behavior, she found herself in the chair of a slim, balding, and effortlessly optimistic psychiatrist--a man whose wisdom and humanity would wrench her from the dangerous tide after she tried to end her life.

The 1980s marked a revolution in the field of organ transplants, and Bud Shaw, MD, who studied under Tom Starzl in Pittsburgh, was on the front lines. Now retired from active practice, Dr. Shaw relays gripping moments of anguish and elation, frustration and reward, despair and hope in his struggle to save patients. He reveals harshly intimate moments of his medical career.

101 True Stories about how Positive Thinking can change your life! Everyone needs a little attitude adjustment once in a while, and these amazing true life stories reveal how real people used positive thinking to improve their lives and overcome challenges. You’ll read stories about how you can make every day a special day, incorporate gratitude and joy into your daily life, count your blessings and change your outlook, use a few well-chosen words to reorient your life, manage cancer and other health challenges through a positive attitude, simplify and have a more meaningful life and more!

One of the funniest and most poignant books ever written about a mental illness, Agorafabulous! is a hilarious, raw, and unforgettable account of how a terrified young woman, literally trapped by her own imagination, evolved into a (relatively) high-functioning professional smartass. Down to earth and seriously funny, Benincasa's no-holds-barred revelations offer listeners the politically incorrect hilarity they heartily crave, yet is so often missing from your typical, weepy, and redemptive personal memoir.

In this book, Galaxy tells the poignant story of his 13-year relationship with a petite gray-and-white short-haired cat named Benny, and gives singular advice for living with, caring for, and loving the feline in your home. When Benny arrived in his life, Galaxy was a down-and-out rock musician with not too much more going on than a part-time job at an animal shelter and a drug problem. Benny's previous owner brought the cat to the shelter in a cardboard box to give him up.

Thirty-four-year-old Rebecca Alexander is a psychotherapist, a spin instructor, a volunteer, and an athlete. She is also almost completely blind, with significantly deteriorated hearing. Not Fade Away is a deeply moving exploration of the obstacles we all face-physical, psychological, and philosophical. Rebecca's story is an exquisite reminder to live each day to its fullest.

Unfiltered. Unapologetic. Older, but not wiser, Lancaster goes back to basics in this hilarious essay collection about everything from taking community policing classes to accidentally getting high with her waiter after a fancy dinner. These are the tales she'd tell if she met you in a bar... if she weren't too lazy to put on pants and go to a bar. Offering advice ranging from how to remain happily married to a man who refuses to blow his damn nose already to not creating An Incident at the cheese counter during an attempt at Whole30, she's you, only louder.

In this electric and provocative debut novel, Amber Tamblyn blends genres of poetry, prose, and elements of suspense to give shape to the shocking narratives of victims of sexual violence, mapping the destructive ways in which our society perpetuates rape culture, brilliantly brought to life through a multi-voice performance featuring Glenn Davis, Ben Foster, Marc Maron, Jason Ritter, John Roberts, Russ Tamblyn, Amber Tamblyn, January Lavoy, Phoebe Strole, Robin Miles, Thérèse Plummer, Dan Bittner, James Fouhey, and Michael Crouch.

It's a report tempered by hard times. In "Matricide", Daum unflinchingly describes a parent's death and the uncomfortable emotions it provokes; and in "Diary of a Coma" she relates her own journey to the twilight of the mind. But Daum also operates in a comic register. With perfect precision, she reveals the absurdities of the marriage-industrial complex, of the New Age dating market, and of the peculiar habits of the young and digital.

Clare Dunkle seemed to have an ideal life - two beautiful, high-achieving teenage daughters, a loving husband, and a satisfying and successful career as a children's book novelist. But it's when you let down your guard that the ax falls. Just after one daughter successfully conquered her depression, another daughter developed a life-threatening eating disorder.