This year marks the 400th anniversary of Galileo’s use of the first telescope. On this week’s show, we reflect on how telescopes have changed our perception of our place in the universe, how small we are in size, space, and time. Our guests include Dava Sobel, author of The Planets, Vatican Astronomer Father Chris Corbally, and astronaut Paul Richards.

Mark Twain said, “Get your facts first, then you can distort them as you please.” Pseudoscience adheres to this adage, but are their distortions deliberate, the result of scientific ignorance, or due to a deep desire for extraordinary possibilities? In our quest to understand the universe, how can we be sure our conclusions are correct? Human beings have evolved to find meaningful patterns in nature, but sometimes the patterns we see are just figments of our imagination — or perhaps the result of wishful thinking.

Special guest Stephen Colbert of Comedy Central's Colbert Report talks about the joys of being a science geek. Brilliant scientific discoveries and cutting edge technology have transformed our world, yet many people are turned off by science. Where has the excitement for science gone, and how can we get it back? Stephen Colbert developed an interest in science at a young age, and now he shares that fascination by inviting scientists to appear on his show The Colbert Report.

Scientists have been searching for aliens in our solar system and beyond, but have not yet found evidence that life exists beyond Earth. SETI, the Search for Extraterrestrial Intelligence, has been scanning the stars for alien radio beacons for 50 years. Radio and TV broadcasts have been leaking from Earth's atmosphere for over a century, and these traveling time capsules could eventually reach a broader audience than ever imagined.

The Star Trek TV and movie series imagine a bright future for humans in space, one in which we explore alien worlds with the aid of advanced technology. Because the writers tried to include as much realistic science as possible within the fictional framework, the stories have been an inspiration for students, scientists, inventors, and anyone interested in pondering our destiny on Earth and beyond. In this show, Brandon Fibbs reviews a Star Trek movie, and Lawrence Krauss talks about how Star Trek uses science to explore what is possible in our universe.