England, 1979. Vincent, Lawrence and William are the last remaining residents of a secluded New Forest home, part of the government's Sycamore Scheme. Every day, the triplets do their chores, play their games and take their medicine, under the watchful eyes of three mothers: Mother Morning, Mother Afternoon and Mother Night.

Robin Edmund Blake is halfway through his life. Born in 1986 as Halley’s Comet crossed our skies, he is destined to go out with it when it returns in 2061. Until then he can't die. He has proof. And until then, he can account for every day and every pound and penny he makes in his lucrative but dull job in the City of London. His future is mapped out, he has a plan to be forever remembered, and he even has Gemma to share it with. But when Robin's sick father has one accident too many, the plan starts to unravel.

Debbie Jones thinks life is an adventure. Even having lost her husband a year ago, she’s ready for whatever the world might throw her way. Being in her sixties doesn’t mean it’s all over for her yet, and she loves her new job doing neighbourhood support for a charity. Then she knocks on a stranger’s front door. Ruth Waverley doesn’t like surprises. Her life isn’t perhaps all she once dreamed off, but what other options are there for a woman in her sixties? She’s proud of her home and children. And she likes her life well enough. Then she hears someone knocking at the door.

Lola de La Peña yearns to be free from the societal expectations of a young Mexican lady of her station. She spends her days pretending to be delicate and proper while watching her mamá cure the sick and injured with sal negra (black salt), a recently discovered magic that heals even the most mortal of sicknesses and wounds. But by night, she is Salvación, the free-spirit lady vigilante protecting the town of Coloma from those who threaten its peace and safety among the rising tension in Alta California after the signing of the Treaty of Guadalupe Hidalgo.

Eager to celebrate her nuptials with her nearest and dearest, Odelia invites her adult children, her daughter-in-law, her grandchild, and her best friend/assistant to an all-expenses-paid luxury safari at Leopard Sands in South Africa, the Babel family’s favorite vacation spot. In its soil, they have deep roots—and even deeper secrets.