It's 1900, and Louise Wilk is taking her dying husband home to Buffalo, where he grew up. Dr. Edward Wilk is wasting away from an aggressive and debilitating malady. But it's becoming clearer that his condition isn't exactly a disease but a phase of existence that seeks to transform and ultimately possess him.

At thirty-six, Katie Cope's life hasn't turned out the way she planned. She had big dreams of becoming an investigative journalist, but then her best friend from college disappeared. Claire was driving home for Thanksgiving and never made it. Her abandoned car was found at a trailhead in the Rockies, but she was never seen again. Now Katie's husband Howard has sold his San Diego business for more money than they ever dreamed. She's found a beautiful new housing development in the breathtaking wilderness of the Colorado mountains. It's just the fresh start we need, she tells him.

Fiona Fisher lives a quiet and contented existence. A former nurse who married Jason, the doctor of her dreams, she is now a mother to his two daughters and living in the sort of cosy village home she’d always wished for.

Widow Mimi lives on idyllic Mackinac Island, where cars are not allowed and a Gibson martini with three onions at the witching hour is compulsory. Her estranged granddaughter, Addie, is getting over the heartbreak of not only being dumped by her fiancé, Brian, but also being cut out of the deal for the brilliantly successful video game Murderscape they invented together (with Addie doing most of the heavy lifting).

I take a sip of coffee as I plan my day. My surgeon husband, Cole, slept at work last night, so I had to get the kids ready on my own, again. I can’t complain, though, I’ve loved him ever since we met, long before he became a famous surgeon and the papers started calling him the pride of the hospital. Our latest family photo hangs on the kitchen wall and I remember that day so clearly. Cole screamed at me over nothing, then apologised saying he was stressed at work. My heart pounded with fear, but I plastered a smile on my face for the sake of my children.