After her teenage daughter, Mia, falls in with the wrong crowd, Dr Billie Green decides it's time to leave the city and return home to Far Western NSW. When an opportunity to pursue her childhood dream of joining the Flying Doctor Service comes along, she jumps at the chance. Flight Nurse Daphne Prince - who is thrilled to have another woman join the otherwise male crew - and their handsome new boss, Morgan Blake, instantly make her feel welcome.

A year after a tragic accident changed her life forever, Tess Daley is in desperate need of a change. When she is offered a position with the Flying Doctor Service, she seizes the opportunity to make a fresh start. Yet once she arrives in remote Mica Ridge she feels like an outsider, unable to connect with her patients and unsure if she'll ever fit in with this outback community.

When the father she barely knew dies suddenly, midwife Eve Wilson decides she owes it to him to go to the funeral and meet her step-family in Red Sand. After disappointment and heartbreak in Sydney, Dr Callie Wilson doesn't hesitate to move home and spend some time with her grieving mother. Melbourne-based obstetrician Sienna Wilson can't understand why anyone would want to bury themselves in the outback, but when her hospital sends her north to research the medical mystery affecting women in Red Sand, it seems fate is intent on bringing the three sisters together.

Thirty-eight year old Cassandra is lost, alone, and grieving. Her much loved grandmother, Nell, has just died and Cassandra, her life already shaken by a tragic accident 10 years ago, feels like she has lost everything known and dear to her.

Lowen Ashleigh is a struggling writer on the brink of financial ruin when she accepts the job offer of a lifetime. Jeremy Crawford, husband of best-selling author Verity Crawford, has hired Lowen to complete the remaining books in a successful series his injured wife is unable to finish. Lowen arrives at the Crawford home, ready to sort through years of Verity's notes and outlines, hoping to find enough material to get her started. What Lowen doesn't expect to uncover in the chaotic office is an unfinished autobiography Verity never intended for anyone to read.