In the year of our Lord 1363, two suspicious deaths in the infirmary of St. Mary's Abbey catch the attention of the powerful John Thoresby, Lord Chancellor of England and Archbishop of York. One victim is a pilgrim, while the second is Thoresby's ne'er-do-well ward, both apparently poisoned by a physic supplied by Master Apothecary Nicholas Wilton. In the wake of these deaths, the archbishop dispatches one-eyed spy Owen Archer to York to find the murderer.

The Earl of Wrexford possesses a brilliant scientific mind, but boredom and pride lead him to reckless behavior. He does not suffer fools gladly. So when pompous, pious Reverend Josiah Holworthy publicly condemns him for debauchery, Wrexford unsheathes his rapier-sharp wit and strikes back. As their war of words escalates, London's most popular satirical cartoonist, A. J. Quill, skewers them both.

It's 1910, and Daniel Pitt is a reluctant lawyer who would prefer to follow in the footsteps of his detective father. When the biographer Russell Graves, who Daniel is helping defend, is sentenced to execution for the murder of his wife, Daniel's Pitt-family investigative instincts kick in, and he sets out to find the real killer. With only 21 days before Graves is to be executed, Daniel learns that Graves is writing a biography of Victor Narraway, the former head of Special Branch and a close friend of the Pitts. And the stories don't shed a positive light. Is it possible someone is framing Graves to keep him from writing the biography-maybe even someone Daniel knows in Special Branch? The only answer, it seems, lies in the dead woman's corpse.

Salisbury, 1226. A young pregnant woman is found tangled in reeds in the river Avon, her identity a mystery. Grieving widow Ela Longespée is determined to succeed her husband as sheriff of Salisbury, and quickly takes charge of the investigation. She soon finds herself in the thick of a neighborhood scandal and a struggle to maintain her authority. With multiple suspects, can she identify the true killer?

Matthew Bartholomew, unorthodox but effective physician to Michaelhouse college in medieval Cambridge, is as worried as anyone about the pestilence that is ravaging Europe and seems to be approaching England. But he is distracted by the sudden and inexplicable death of the Master of Michaelhouse - a death the University authorities do not want investigated.