When two strangers are linked by a mail-in DNA test, it’s an answered prayer- that is, for one half sister. For the other, it will dismantle everything she knows to be true. But as they step into the unfamiliar realm of sisterhood, the roles will reverse in ways no one could have foreseen. Caroline lives a full, happy life - thriving career, three feisty children, enviable marriage, and a close-knit extended family. She couldn’t have scripted it better. Except for one thing: She’s about to discover her fundamental beliefs about them all are wrong.

When a group of neighborhood women gathers, wine in hand, around a fire pit where their backyards meet one Saturday night, most of them are just ecstatic to have discovered that their baby monitors reach that far. It's a rare kid-free night, and they're giddy with it. They drink too much, and the conversation turns personal. By Monday morning, one of them is gone. Everyone knows something about everyone else in the quirky small Ohio town of Yellow Springs, but no one can make sense of the disappearance.

Violet and Finn were “meant to be,” said everyone, always. They ended up together by the hands of fate aligning things just so. Three years into their marriage, they have a wonderful little boy, and as the three of them embark on their first vacation as a family, Violet can’t help thinking that she can’t believe her luck. Life is good. So no one is more surprised than she when Finn leaves her at the beach—just packs up the hotel room and disappears. And takes their son with him.

Olivia McAfee knows what it feels like to start over. Her picture-perfect life—living in Boston, married to a brilliant cardiothoracic surgeon, raising their beautiful son, Asher—was upended when her husband revealed a darker side. She never imagined that she would end up back in her sleepy New Hampshire hometown, living in the house she grew up in and taking over her father’s beekeeping business. Lily Campanello is familiar with do-overs, too. When she and her mom relocate to Adams, New Hampshire, for her final year of high school, they both hope it will be a fresh start.

If Avery Chambers can’t fix you in 10 sessions, she won’t take you on as a client. Her successes are phenomenal—she helps people overcome everything from domineering parents to assault—and almost absorbs the emptiness she sometimes feels since her husband’s death. Marissa and Mathew Bishop seem like the golden couple—until Marissa cheats. She wants to repair things, both because she loves her husband and for the sake of their eight-year-old son. After a friend forwards an article about Avery, Marissa takes a chance on this maverick therapist.

Nisha Cantor lives the globetrotting life of the seriously wealthy, until her husband announces a divorce and cuts her off. Nisha is determined to hang onto her glamorous life. But in the meantime, she must scramble to cope--she doesn’t even have the shoes she was, until a moment ago, standing in. That’s because Sam Kemp—in the bleakest point of her life—has accidentally taken Nisha’s gym bag. But Sam hardly has time to worry about a lost gym bag—she’s struggling to keep herself and her family afloat.

After Tova Sullivan’s husband died, she began working the night shift at the Sowell Bay Aquarium, mopping floors and tidying up. Keeping busy has always helped her cope, which she’s been doing since her eighteen-year-old son, Erik, mysteriously vanished on a boat in Puget Sound over thirty years ago. Tova becomes acquainted with curmudgeonly Marcellus, a giant Pacific octopus living at the aquarium. Marcellus knows more than anyone can imagine but wouldn’t dream of lifting one of his eight arms for his human captors—until he forms a remarkable friendship with Tova.

William Waters grew up in a house silenced by tragedy, where his parents could hardly bear to look at him, much less love him—so when he meets the spirited and ambitious Julia Padavano in his freshman year of college, it’s as if the world has lit up around him. With Julia comes her family, as she and her three sisters are inseparable: Sylvie, the family’s dreamer, is happiest with her nose in a book; Cecelia is a free-spirited artist; and Emeline patiently takes care of them all.

Chemist Elizabeth Zott is not your average woman. In fact, Elizabeth Zott would be the first to point out that there is no such thing as an average woman. But it’s the early 1960s and her all-male team at Hastings Research Institute takes a very unscientific view of equality. Except for one: Calvin Evans; the lonely, brilliant, Nobel–prize nominated grudge-holder who falls in love with—of all things—her mind. True chemistry results.

Seventeen-year-old Lenni Pettersson lives on the Terminal Ward at the Glasgow Princess Royal Hospital. Though the teenager has been told she’s dying, she still has plenty of living to do. Joining the hospital’s arts and crafts class, she meets the magnificent Margot, an 83-year-old, purple-pajama-wearing, fruitcake-eating rebel, who transforms Lenni in ways she never imagined. As their friendship blooms, a world of stories opens for these unlikely companions who, between them, have been alive for one hundred years.

Mia, the irreverent, hyperanalytical twenty-year-old daughter, has an explanation for everything—which is why she isn’t initially concerned when her father and younger brother Eugene don’t return from a walk in a nearby park. They must have lost their phone. Or stopped for an errand somewhere. But by the time Mia’s brother runs through the front door bloody and alone, it becomes clear that the father in this tight-knit family is missing and the only witness is Eugene, who has the rare genetic condition Angelman syndrome and cannot speak.

On the eve of her 40th birthday, Alice’s life isn’t terrible. She likes her job, even if it isn’t exactly the one she expected. She’s happy with her apartment, her romantic status, her independence, and she adores her lifelong best friend. But her father is ailing, and it feels to her as if something is missing. When she wakes up the next morning she finds herself back in 1996, reliving her 16th birthday.

When 39-year-old Maria Forssmann wakes up in her 17-year-old body, she doesn’t know how she got there. All she does know is she has to get back: to her home in Bienville, Mississippi, to her job as a successful psychiatrist and, most importantly, to her husband, daughters, and unborn son.

Everyone knows everyone in the tiny town of Bourne, but the Mitchell triplets are especially beloved. Mirabel is the smartest person anyone knows, and no one doubts it just because she can’t speak. Monday is the town’s purveyor of books now that the library’s closed - tell her the book you think you want, and she’ll pull the one you actually do from the microwave or her sock drawer. Mab’s job is hardest of all: get good grades, get into college, get out of Bourne.

When Katy’s mother dies, she is left reeling. Carol wasn’t just Katy’s mom, but her best friend and first phone call. She had all the answers and now, when Katy needs her the most, she is gone. To make matters worse, their planned mother-daughter trip of a lifetime looms: to Positano, the magical town where Carol spent the summer right before she met Katy’s father. Katy has been waiting years for Carol to take her, and now she is faced with embarking on the adventure alone.

Katie’s divorce was, in a word, humiliating. So when her friend Bess offers a fresh start—a resident caretaking job at a nature preserve—Katie accepts. No matter that she’s not exactly a “nature person.” How hard can it be? But from day one, something feels off. Katie’s new farmhouse looks as if the last caretaker barely moved out at all. When a frantic, terrified woman arrives late at night, expecting a safe place to hide, it’s clear caretaking involves way more than Katie bargained for.

If Lark and Mikki didn’t have each other, they’d have nothing in this miserable town. So the best friends stick together, working night shift at the highway travel stop, going nowhere fast. Until a stranger drops in, heading for Florida, and Mikki impulsively leaves with him, never to be seen again. Eight years later, Lark is finally getting her life back together for the sake of her young daughter and Mikki’s lovably prickly grandma, who can no longer care for herself. People have almost stopped blaming Lark for Mikki’s disappearance, and she’s engaged to the nicest guy on highway patrol.

When a group of neighborhood women gathers, wine in hand, around a fire pit where their backyards meet one Saturday night, most of them are just ecstatic to have discovered that their baby monitors reach that far. It's a rare kid-free night, and they're giddy with it. They drink too much, and the conversation turns personal. By Monday morning, one of them is gone. Everyone knows something about everyone else in the quirky small Ohio town of Yellow Springs, but no one can make sense of the disappearance.

When two strangers are linked by a mail-in DNA test, it’s an answered prayer- that is, for one half sister. For the other, it will dismantle everything she knows to be true. But as they step into the unfamiliar realm of sisterhood, the roles will reverse in ways no one could have foreseen. Caroline lives a full, happy life - thriving career, three feisty children, enviable marriage, and a close-knit extended family. She couldn’t have scripted it better. Except for one thing: She’s about to discover her fundamental beliefs about them all are wrong.

Violet and Finn were “meant to be,” said everyone, always. They ended up together by the hands of fate aligning things just so. Three years into their marriage, they have a wonderful little boy, and as the three of them embark on their first vacation as a family, Violet can’t help thinking that she can’t believe her luck. Life is good. So no one is more surprised than she when Finn leaves her at the beach—just packs up the hotel room and disappears. And takes their son with him.