Seventeen years ago, the grand Venetian Palazzo degli Angeli was Phoebe Wyndham's home; now, the neglected walls of the palazzo are just a haunting reminder of all she has lost. Arriving back in Italy after a plea from her estranged relative, the Contessa di Sebastiano, the recently widowed Phoebe is shocked to discover her aunt is dead and the palazzo now belongs to her. All she wants to do is sell the property and return home.

It's 1813. Venetia Lovell lives by the sea in Kent with her pretty, frivolous mother and idle younger brother. Venetia's father, Theo, is an interior decorator to the rich and frequently travels away from home, leaving his sensible and artistic daughter to look after the family. Venetia designs paper hangings, and she and her father often daydream about having an imaginary shop where they would display the highest quality furniture, fabrics and art to his clients.

1891. Spindrift House, Cornwall. Talented painter, Edith Fairchild, is poised to begin a life of newlywed bliss, and artistic creation, with her charming husband Benedict. He recently inherited Spindrift House near Port Isaac, and Edith is inspired by the glorious Cornish light and the wonderful setting overlooking the sea. But then happiness turns to heartbreak. In great distress, Edith turns to an artist friend for comfort, and after a bitterly-regretted moment of madness, she finds herself pregnant with his child. Too ashamed to reveal her secret, Edith devotes herself to her art.

Italy in 1819. Emilia Barton and her mother, Sarah, live a nomadic existence, travelling from town to town as itinerant dressmakers to escape their past. When they settle in the idyllic coastal town of Pesaro, Emilia desperately hopes that this time they have found a permanent home. But when Sarah is brutally attacked by an unknown assailant, a deathbed confession turns Emilia's world upside down. Seeking refuge as a dressmaker in the eccentric household of Princess Caroline of Brunswick, Emilia experiences her first taste of love with the charming Alessandro.

Susannah Leyton has grown up behind the counter of her father's apothecary shop in bustling Fleet Street. A skilled student, her father has granted her the freedom to pursue her considerable talents. But Susannah is dealt a shocking blow when her widowed father marries again, and her stepmother seems determined to remove her from the apothecary shop. A proposal of marriage from the charming Henry Savage seems to offer Susannah an escape. But as the plague sweeps through London, tragedy strikes, and dark secrets from her husband's past begin to unfold.