It is 1914, and as the war draws the young men of Britain away to fight, women must keep the nation running. Two of those women are Peggy and Maude, twin sisters who live on a narrowboat in Oxford and work in the bindery at the university press.

Brooklyn, 1924. As New York City enters the jazz age, the lives of three very different women are about to converge in unexpected ways. Recently arrived from New Orleans, Beatrice is working to establish a chic new dress shop with help from Alice, the orphaned teenage ward she brought north with her. Down the block, newlywed Catherine is restless in her elegant brownstone, longing for a baby she cannot conceive.

In pre-war Prague, the dreams of two young lovers are shattered when they are separated by the Nazi invasion. Then, decades later, thousands of miles away in New York, there's an inescapable glance of recognition between two strangers. Providence is giving Lenka and Josef one more chance. From the glamorous ease of life in Prague before the Occupation, to the horrors of Nazi Europe, The Lost Wife explores the power of first love, the resilience of the human spirit, and the strength of memory.

In Boston, 1865, Charlotte and Henrietta Stevenson, daughters of a Massachusetts Supreme Court Justice, have accomplished as much as women are allowed in those days. Chafing against those restrictions and inspired by the works of Jane Austen, they start a secret correspondence with Sir Francis Austen, her last surviving brother, now in his nineties. He sends them an original letter from his sister and invites them to come visit him in England.

1946: World War II is over, and Emma Clarkson is poised to take flight. With dreams of attending university, she’s ready to leave behind the wild beauty of Sable Island, the only home she’s ever known. But when a handsome British sea captain is rescued from a nearby shipwreck, her destiny is forever changed. Emma falls deeply in love with Oliver Harris, but their romance is not meant to be. Oliver returns to the sea, while Emma vows to forget him and pursue her own ambitions.