Peter and Adele Robinson were dragged up by an alcoholic, violent father and a beaten mother, their childhood in Manchester preparing them only for a life of crime. Adele studies hard and makes a success of her life whilst Peter immerses himself in the murky underworld of crime, and their once close bond breaks. However, when Adele is in danger, there's only one person she can turn to...her brother.

If you met a troubled stranger who needed help, what would you do? If she had a haunted air about her, startled, hunted eyes, would you reach out? Tanya Smith, a beautiful East End stripper stumbling her way through life, finds herself gaining an impromptu flatmate one night after a chance meeting with a lost young woman. Anna Davis, on the run from a dangerous and stormy past, starts up a new life, keeping one eye over her shoulder and her secrets close to her chest.

An unassuming Dottie Ellis falls for bad boy Jimmy Carson, who sweeps her off her feet. But after discovering she is pregnant and learning that Jimmy has gone back to his ex-girlfriend Carrie Verne, her happiness falls apart. Heartbroken, Dottie runs home, only to unearth a disturbing family secret that rocks her to the core. She is now faced with an agonizing decision to protect her unborn child. What she does shocks the town. In a moment of solidarity, Carrie makes a promise to Dottie, cementing an unlikely bond between them.

When Julie Quinley wakes up after a night out with friends to find herself accused of murder, it proves to be only the beginning of her worst nightmare. Released by the police due to lack of evidence, Julie nevertheless faces the taunts and hostility of colleagues, as more and more people – including members of her own family – seem convinced she is a cold-hearted killer. Just when it seems as if all hope has gone, and Julie's mental state reaches rock bottom, her friend Vinny announces a breakthrough; something he has witnessed that could prove Julie's innocence once and for all.

When underworld loan shark Davie Saunders is gunned down at his daughter's wedding, his loved ones are sure that a rival East End crime family is responsible. Davie's widow and daughters must now step up and take control of Davie's empire, but from the beginning it's clear they're in way over their heads. Shy bride Mia has no experience of giving orders, self-centred middle-child Kelsey is more concerned with keeping her affair with bodyguard Todd a secret, and baby of the family Scarlett is very firmly kept out of the business while she finishes her education.