In a quiet suburb of New Delhi, two next-door neighbors develop a friendship: one, a young woman engaged to be married, and the other, Nadine: a woman in her 60s living with her second husband. We follow these two women through their phone calls and visits together, diving deeper into Nadine's storied past: With her larger-than-life personality and proclivity to defy society's conventions, her insight weighs heavily on her young friend, about to face a major turning point of her own.

The opening sentence of John Irving's breakout novel, The World According to Garp, signals the start of sexual violence, which becomes increasingly political. "Garp's mother, Jenny Fields, was arrested in Boston in 1942 for wounding a man in a movie theater." Jenny is an unmarried nurse; she becomes a single mom and a feminist leader, beloved but polarizing. Her son, Garp, is less beloved, but no less polarizing.

When Marty Preston comes across a young beagle in the hills behind his home, it's love at first sight - and also big trouble. It turns out the dog, which Marty names Shiloh, belongs to Judd Travers, who drinks too much and has a gun - and abuses his dogs. So when Shiloh runs away from Judd to Marty, Marty just has to hide him and protect him from Judd.

Fourteen-year-old Angie and her mom are poised at the edge of homelessness...again. The problem is her little sister, Sophie. Sophie has an autism-like disorder and a tendency to shriek. No matter where they live, home never seems to last long. Until they move in with Aunt Vi, across the fence from a huge, black Great Dane who changes everything.

Olivia McAfee knows what it feels like to start over. Her picture-perfect life—living in Boston, married to a brilliant cardiothoracic surgeon, raising their beautiful son, Asher—was upended when her husband revealed a darker side. She never imagined that she would end up back in her sleepy New Hampshire hometown, living in the house she grew up in and taking over her father’s beekeeping business. Lily Campanello is familiar with do-overs, too. When she and her mom relocate to Adams, New Hampshire, for her final year of high school, they both hope it will be a fresh start.

Jacob Hunt is a teen with Asperger's syndrome. He's hopeless at reading social cues or expressing himself well to others, though he is brilliant in many ways. But he has a special focus on one subject - forensic analysis. A police scanner in his room clues him in to crime scenes, and he's always showing up and telling the cops what to do. And he's usually right. But when Jacob's small hometown is rocked by a terrible murder, law enforcement comes to him. Jacob's behaviors are hallmark Asperger's, but they look a lot like guilt to the local police.

The Voss family is anything but normal. They live in a repurposed church, newly baptized Dollar Voss. The once cancer-stricken mother lives in the basement, the father is married to the mother’s former nurse, the little half-brother isn’t allowed to do or eat anything fun, and the eldest siblings are irritatingly perfect. Then, there’s Merit. Merit Voss collects trophies she hasn’t earned and secrets her family forces her to keep. While browsing the local antiques shop for her next trophy, she finds Sagan.

On the surface, Niru leads a charmed life. Raised by two attentive parents in Washington, DC, he's a top student and a track star at his prestigious private high school. Bound for Harvard in the fall, his prospects are bright. But Niru has a painful secret: He is queer - an abominable sin to his conservative Nigerian parents. No one knows except Meredith, his best friend, the daughter of prominent Washington insiders - and the one person who seems not to judge him.

Emma and Bobby Ross enjoy a charmed life on the shores of Miami Beach. They are a model family with a successful business, an uncomplicated marriage, and two blessedly typical twin daughters, Zoe and Lily. They are established members of a tight-knit community. Then, on the night of the girls’ fifteenth birthday party, they learn of Zoe’s heartbreaking mistake - a private and humiliating indiscretion that goes viral and thrusts her and her family into the center of a shocking public scandal.

Seventeen-year-old Aussie Che Taylor loves his younger sister Rosa. But he's also certain that she's a diagnosable psychopath - clinically, threateningly, dangerously. Recently Rosa has been making trouble, hurting things. Che is the only one who knows; he's the only one his sister trusts. Rosa is smart, talented, pretty, and very good at hiding what she is and the violence she's capable of. Their parents, whose business takes the family from place to place, brush off the warning signs as Rosa's "acting out".

Mia, the irreverent, hyperanalytical twenty-year-old daughter, has an explanation for everything—which is why she isn’t initially concerned when her father and younger brother Eugene don’t return from a walk in a nearby park. They must have lost their phone. Or stopped for an errand somewhere. But by the time Mia’s brother runs through the front door bloody and alone, it becomes clear that the father in this tight-knit family is missing and the only witness is Eugene, who has the rare genetic condition Angelman syndrome and cannot speak.

In Shaker Heights, a placid, progressive suburb of Cleveland, everything is planned - from the layout of the winding roads to the colors of the houses to the successful lives its residents will go on to lead. And no one embodies this spirit more than Elena Richardson, whose guiding principle is playing by the rules. Enter Mia Warren - an enigmatic artist and single mother - who arrives in this idyllic bubble with her teenage daughter, Pearl, and rents a house from the Richardsons.

Fifteen-year-old Christopher Boone has Asperger's Syndrome, a condition similar to autism. He doesn't like to be touched or meet new people, he cannot make small talk, and he hates the colors brown and yellow. He is a math whiz with a very logical brain who loves solving puzzles that have definite answers.

Connell and Marianne grew up in the same small town, but the similarities end there. At school, Connell is popular and well liked, while Marianne is a loner. But when the two strike up a conversation - awkward but electrifying - something life changing begins. A year later, they’re both studying at Trinity College in Dublin. Marianne has found her feet in a new social world while Connell hangs at the sidelines, shy and uncertain. Throughout their years at university, Marianne and Connell circle one another.

Nina Browning is living the good life after marrying into Nashville's elite. More recently, her husband made a fortune selling his tech business, and their adored son has been accepted to Princeton. Yet sometimes the middle-class small-town girl in Nina wonders if she's strayed from the person she once was. Tom Volpe is a single dad working multiple jobs while struggling to raise his headstrong daughter, Lyla. His road has been lonely, long, and hard, but he finally starts to relax after Lyla earns a scholarship to Windsor Academy, Nashville's most prestigious private school.