Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis

Inavolisib-Based Therapy in PIK3CA-Mutated Advanced Breast Cancer

Isatuximab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma

Total Hip Replacement or Resistance Training for Severe Hip Osteoarthritis

from Journal of American Medical Association

Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis

The EVOLVED Randomized Clinical Trial

Annals of Internal Medicine

Projected Impact and Cost-Effectiveness of Novel Molecular Blood-Based or Stool-Based Screening Tests for Colorectal Cancer

Comparative Effectiveness and Safety of Atorvastatin Versus Rosuvastatin: A Multi-database Cohort Study

British Medical Journal

Comparative effectiveness of sodium-glucose cotransporter-2 inhibitors for recurrent nephrolithiasis among patients with pre-existing nephrolithiasis or gout: target trial emulation studies

Lancet

The effect of tranexamic acid on postpartum bleeding in women with moderate and severe anaemia (WOMAN-2): an international, randomised, double-blind, placebo-controlled trial

Journal of Clinical Oncology

Randomized Phase II Trial of Immunotherapy-Based Total Neoadjuvant Therapy for Proficient Mismatch Repair or Microsatellite Stable Locally Advanced Rectal Cancer (TORCH)

journal of Hepatology

Histological improvements following energy restriction and exercise: The role of insulin resistance in resolution of MASH

Gastroenterology

A Single-Cell Atlas of the Murine Pancreatic Ductal Tree Identifies Novel Cell Populations With Potential Implications in Pancreas Regeneration and Exocrine Pathogenesis

Fazirsiran for Adults With Alpha-1 Antitrypsin Deficiency Liver Disease: A Phase 2 Placebo Controlled Trial (SEQUOIA)

Clinical Infectious Diseases

Evidence-Informed Provision of Doxycycline Post-Exposure Prophylaxis for Prevention of Bacterial Sexually Transmitted Infections

Abstract

Rheumatology

Implementing Patient Health Questionnaire Depression Screening in Inflammatory Arthritis Clinic: Insights From a Quality Improvement Project at a Tertiary Rheumatology Center

Circulation

RNA Helicase DDX5 Maintains Cardiac Function by Regulating CamkIIδ Alternative Splicing

Journals of the American College of Cardiology

Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis

JAMA Cardiology

Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure

Journal of Clinical Endocrinology & Metabolism

Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas

Diabetes care

Sitting Time and Its Interaction With Physical Activity in Relation to All-Cause and Heart Disease Mortality in U.S. Adults With Diabetes

The American Journal of Respiratory and Critical Care Medicine

The Effect of Positive End-Expiratory Pressure on Pulmonary Vascular Resistance Depends on Lung Recruitability in Patients with Acute Respiratory Distress Syndrome

Rationale: A U-shaped relationship should exist between lung volume and Kidney International reports

Prospective Trial on the Pharmacokinetics of Clopidogrel in Hemodialysis Patients

A Survey on End-of-Life Contemplation Among Patients on Dialysis