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in New England Journal of Medicine

Nationwide, Couple-Based Genetic Carrier Screening

Adjunctive Middle Meningeal Artery Embolization for Subdural Hematoma

Safety and Efficacy of Immunization with a Late-Liver-Stage Attenuated Malaria Parasite

Journal of American Medical Association

Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores

Zerlasiran—A Small-Interfering RNA Targeting Lipoprotein(a): A Phase 2 Randomized Clinical Trial

Annals of Internal Medicine

The Effect of Denosumab on Risk for Emergently Treated Hypocalcemia by Stage of Chronic Kidney Disease

British Medical Journal

Nurse and doctor turnover and patient outcomes in NHS acute trusts in England

Lancet

Induced pluripotent stem-cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human interventional study in Japan

Cancer Journal for Clinicians

Efficacy and safety of nivolumab monotherapy in patients with unresectable clear cell sarcoma and alveolar soft part sarcoma

Journal of Clinical Oncology

Trastuzumab Deruxtecan in Advanced Solid Tumors With Human Epidermal Growth Factor Receptor 2 Amplification Identified by Plasma Cell-Free DNA Testing: A Multicenter, Single-Arm, Phase II Basket Trial

Hepatology

Sodium taurocholate cotransporting polypeptide (NTCP) polymorphisms may influence HDV RNA load and early response to bulevirtide

Hepatic venous pressure gradient predicts risk of hepatic decompensation and liver-related mortality in patients with MASLD

Gastroenterology

Molecular Mechanisms Underlying Loss of Vascular and Epithelial Integrity in Irritable Bowel Syndrome

Clinical Gastroenterology

Prevalence and Determinants of Liver Disease in Relatives of Italian Patients With Advanced MASLD

Clinical Infectious Diseases

Prevalence, Clinical Severity, and Serotype Distribution of Pneumococcal Pneumonia Among Adults Hospitalized With Community-Acquired Pneumonia in Tennessee and Georgia, 2018–2022

Rheumatology

Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis

Journal of Clinical Rheumatology

Prevalence and Clinical Implications of Autoantibodies in Juvenile Dermatomyositis: A Single-Center Experience From India

Circulation

Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction

Journals of the American College of Cardiology

Complete vs Culprit-Only Revascularization in Older Patients With Myocardial Infarction With or Without ST-Segment Elevation

JAMA Cardiology

Verinurad Plus Allopurinol for Heart Failure With Preserved Ejection FractionThe AMETHYST Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

Hemostatic Effects of Exercise-related Hypoglycemia in Male Persons With Type 1 Diabetes

Diabetes care

Trends in Racial and Ethnic Disparities in Early Glycemic Control Among Veterans Receiving Care in the Veterans Health Administration, 2008–2019

Neurology

Quantitative MRI Measures and Cognitive Function in People With Drug-Resistant Juvenile Myoclonic Epilepsy

Chest

Air Pollution Metabolomic Signatures and Chronic Respiratory Diseases Risk

A Longitudinal Study

The American Journal of Respiratory and Critical Care Medicine

Lung-Protective Mechanical Ventilation in Patients with Severe Acute Brain Injury: A Multicenter Randomized Clinical Trial (PROLABI)

Clinical Journal of American Society of Nephrology

Physical Function and Mortality in Older Adults with Chronic Kidney Disease

Kidney International reports

Associations of Urine Epidermal Growth Factor With Kidney and Cardiovascular Outcomes in Individuals With CKD in SPRINT

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New England Journal of Medicine

Perioperative Durvalumab with Neoadjuvant Chemotherapy in Operable Bladder Cancer

Transcatheter Repair versus Mitral-Valve Surgery for Secondary Mitral Regurgitation

Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation

Preoperative Chemoradiotherapy for Resectable Gastric Cancer

Journal of American Medical Association

Symptom Screening Linked to Care Pathways for Pediatric Patients With Cancer: A Randomized Clinical Trial

Tenofovir and Hepatitis B Virus Transmission During Pregnancy

Symptom Screening Linked to Care Pathways for Pediatric Patients With Cancer

Annals of Internal Medicine

Association Between False-Positive Results and Return to Screening Mammography in the Breast Cancer Surveillance Consortium Cohort

British Medical Journal

SGLT-2 inhibitors and mortality among patients with heart failure with reduced ejection fraction

Malnutrition in infants aged 6-23 months in China’s poorest rural counties from 2016 to 2021

Lancet

Genetic sequencing analysis of monkeypox virus clade I in Republic of the Congo: a cross-sectional, descriptive study

Cancer Journal for Clinicians

Comparison of infection risk between enzalutamide and abiraterone in patients with prostate cancer

Journal of Clinical Oncology

Stockholm3 in a Multiethnic Cohort for Prostate Cancer Detection (SEPTA): A Prospective Multicentered Trial

Hepatology

CRISPR-Cas13b-mediated suppression of HBV replication and protein expression

Epigenetic scars in regulatory T cells are retained after successful treatment of chronic hepatitis C with direct-acting antivirals

Gastroenterology

The Global Incident Gastrointestinal Cancers Attributable to Suboptimal Diets From 1990 to 2018

Clinical Gastroenterology

The Efficacy of Real-time Computer-aided Detection of Colonic Neoplasia in Community Practice: A Pragmatic Randomized Controlled Trial

Clinical Infectious Diseases

Preventing New Gram-negative Resistance Through Beta-lactam De-escalation in Hospitalized Patients With Sepsis: A Retrospective Cohort Study

Rheumatology

Gout Flare Burden in the United States: A Multiyear Cross‐Sectional Survey Study

Journal of Clinical Rheumatology

Development and Validation of Nosocomial Bacterial Infection Prediction Models for Patients With Systemic Lupus Erythematosus

Circulation

Complete Versus Culprit-Only Revascularization in Older Patients With ST-Segment–Elevation Myocardial Infarction: An Individual Patient Meta-Analysis

Journals of the American College of Cardiology

Comprehensive Proteomic Profiling of Human Myocardium Reveals Signaling Pathways Dysregulated in Hypertrophic Cardiomyopathy

JAMA Cardiology

Prehospital Pulse-Dose Glucocorticoid in ST-Segment Elevation Myocardial InfarctionThe PULSE-MI Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

Medullary Thyroid Cancer: Single Institute Experience Over 3 Decades and Risk Factors for Recurrence

Diabetes care

Development of a Core Outcome Set for Studies Assessing Interventions for Diabetes-Related Foot Ulceration

Neurology

Identification of Genetic Loci Associated With Intracerebral Hemorrhage Using a Multitrait Analysis Approach

Chest

Sex Differences After Treatment With Ivacaftor in People With Cystic Fibrosis

The American Journal of Respiratory and Critical Care Medicine

Low-Dose Morphine Does Not Cause Sleepiness in Chronic Obstructive Pulmonary Disease: A Secondary Analysis of a Randomized Clinical Trial

Clinical Journal of American Society of Nephrology

Association between Chronic Kidney Disease-Mineral and Bone Disorder Biomarkers and Symptom Burden in Older Patients with Advanced Chronic Kidney Disease: Results from the EQUAL Study

Kidney International reports

IMPACT CKD: Holistic Disease Model Projecting 10-Year Population Burdens

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New England Journal of Medicine

Invasive Treatment Strategy for Older Patients with Myocardial Infarction

Randomized Trial of Very Early Medication Abortion

Neoadjuvant Nivolumab and Ipilimumab in Resectable Stage III Melanoma

Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma

Journal of American Medical Association

Postmarketing Surveillance of Inferior Vena Cava Filters Among US Medicare Beneficiaries

The SAFE-IVC Study

A Digital Health Behavior Intervention to Prevent Childhood Obesity

The Greenlight Plus Randomized Clinical Trial

Annals of Internal Medicine

Ensuring Safe Practice by Late Career Physicians: Institutional Policies and Implementation Experiences

British Medical Journal

SGLT-2 inhibitors and mortality among patients with heart failure with reduced ejection fraction

Lancet

Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial

Cancer Journal for Clinicians

Epidemiology, treatment patterns, and clinical outcomes in de novo oligometastatic hormone-sensitive prostate cancer

Journal of Clinical Oncology

Addition of Metastasis-Directed Therapy to Systemic Therapy for Oligometastatic Pancreatic Ductal Adenocarcinoma (EXTEND): A Multicenter, Randomized Phase II Trial

journal of Hepatology

Diagnostic performance of non-invasive tests in patients with MetALD in a health check-up cohort

Histological improvements following energy restriction and exercise: The role of insulin resistance in resolution of MASH

Gastroenterology

Gluten-Dependent Activation of CD4+ T Cells by MHC Class II–Expressing Epithelium

Clinical Gastroenterology

Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial

Clinical Infectious Diseases

Successful Treatment of Carbapenem-Resistant Acinetobacter baumannii Meningitis With Sulbactam-Durlobactam

Rheumatology

Comprehensive Enteroviral Serology Links Infection and Anti‐Melanoma Differentiation‐Associated Protein 5 Dermatomyositis

Journal of Clinical Rheumatology

Factors Associated With Successful Withdrawal of Biologic Agents in Children With Colchicine-Resistant Familial Mediterranean Fever

Circulation

Contemporary Outcomes and Trends for the Transseptal Mitral Valve-in-Valve Procedure Using Balloon Expandable Transcatheter Valves in the United States

Journals of the American College of Cardiology

Reaffirmation of Mechanistic Proteomic Signatures Accompanying SGLT2 Inhibition in Patients With Heart Failure: A Validation Cohort of the EMPEROR Program

Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure

Journal of Clinical Endocrinology & Metabolism

Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas

Diabetes care

Health Care Utilization and Costs Associated With Empagliflozin in Older Adults With Type 2 Diabetes

Neurology

Frequency and Longitudinal Course of Behavioral and Neuropsychiatric Symptoms in Participants With Genetic Frontotemporal Dementia

Chest

Primary Ciliary Dyskinesia in Adult Bronchiectasis

American Journal of Respiratory and Critical Care Medicine

Discovery and Validation of a Volatile Signature of Eosinophilic Airway Inflammation in Asthma

Clinical Journal of American Society of Nephrology

Urine Output and Acute Kidney Injury in Neonates/Younger Children: A Prospective Study of Cardiac Surgery Patients with Indwelling Urinary Catheters

Large Discordance between Creatinine-Based and Cystatin C–Based eGFRs is Associated with Falls, Hospitalizations, and Death in Older Adults

Kidney International reports

Systematic Review of Individual Patient Data COVID-19 Infection and Vaccination–Associated Thrombotic Microangiopathy