Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation

Efruxifermin in Compensated Liver Cirrhosis Caused by MASH

Journal of American Medical Association

Complete AI-Enabled Echocardiography Interpretation With Multitask Deep Learning

Annals of Internal Medicine

Risk for Stroke After Newly Diagnosed Atrial Fibrillation During Hospitalization for Other Primary Diagnoses

British Medical Journal

Effect of UK Quality and Outcomes Framework pay-for-performance programme on quality of primary care

journal of Hepatology

Histological severity, clinical outcomes and impact of antiviral treatment in indeterminate phase of chronic hepatitis B: A systematic review and meta-analysis

Clinical Gastroenterology

The Tissue Systems Pathology Test Objectively Risk-Stratifies Patients With Barrett’s Esophagus: Results From a Multicenter US Clinical Experience Study

Delayed Perforation After Endoscopic Resection of Upper Gastrointestinal Tumors: CT Findings to Identify Patients Requiring Surgery

Clinical Infectious Diseases

Antimicrobial Stewardship and Beyond: The Many Essential Roles of Infectious Diseases Pharmacists

Circulation

Lymphatic Endothelial Branched-Chain Amino Acid Catabolic Defects Undermine Cardiac Lymphatic Integrity and Drive HFpEF

Journals of the American College of Cardiology

Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension:

JAMA Cardiology

Asundexian or Apixaban in Patients With Atrial Fibrillation According to Prior Oral Anticoagulant UseA Subgroup Analysis of the OCEANIC-AF Randomized Clinical Trial

Journal of Clinical Endocrinology & Metabolism

Decreased Neutrophils Are Associated With Reduced Risk of Type 2 Diabetes Incidence

Diabetes care

Cellular Versus Acellular Matrix Products for Diabetic Foot Ulcer Treatment: The Dermagraft and Oasis Longitudinal Comparative Efficacy Study (DOLCE)—A Randomized Clinical Trial

Neurology

Noninvasive Assessment of the Risk Features of Hemorrhage in Moyamoya Disease Using 7T MRI

Chest

Preserved Ratio Impaired Spirometry Prevalence, Risk Factors, and Outcomes

The American Journal of Respiratory and Critical Care Medicine

Elastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome

Clinical Journal of American Society of Nephrology

Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Patients with and without Advanced CKD: Systematic Review and Meta-Analysis

Kidney International reports

Dotinurad Treatment for Patients With Hyperuricemia Complicating CKD

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis

Navigational Bronchoscopy or Transthoracic Needle Biopsy for Lung Nodules

Omitting Regional Nodal Irradiation after Response to Neoadjuvant Chemotherapy

A Trial of Trimethoprim–Sulfamethoxazole in Pregnancy to Improve Birth Outcomes

Journal of American Medical Association

Clinical Validation of a Circulating Tumor DNA–Based Blood Test to Screen for Colorectal Cancer

Annals of Internal Medicine

Effects of a Hypotension-Avoidance Versus a Hypertension-Avoidance Strategy on Neurocognitive Outcomes After Noncardiac Surgery

Lancet

Comparison of supplemental breast cancer imaging techniques—interim results from the BRAID randomised controlled trial

Journal of Clinical Oncology

Explaining the Relationships Between Age, Endocrine Therapy Persistence, and Risk of Recurrence in Hormone Receptor–Positive Early Breast Cancer: A Nationwide Cohort Study

journal of Hepatology

Utility of AI digital pathology as an aid for pathologists scoring fibrosis in MASH

Gastroenterology

Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease

Clinical Gastroenterology

The Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation

Clinical Infectious Diseases

Association Between Delayed Broad-Spectrum Gram-negative Antibiotics and Clinical Outcomes

Rheumatology

Prevalence of Frailty and Associated Factors in a US-Wide Cohort of Rheumatic Diseases

Journals of the American College of Cardiology

Disentangling the Impact of Adiposity From Insulin Resistance in Heart Failure With Preserved Ejection Fraction

JAMA Cardiology

Sex-Specific Association of Myocardial Fibrosis With Mortality in Patients With Aortic Stenosis

Diabetes care

Cardiovascular and Kidney Outcomes and Mortality With Long-Acting Injectable and Oral Glucagon-Like Peptide 1 Receptor Agonists in Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Trials

Neurology

Association of Nonmodifiable Risk Factors With Alzheimer Disease Blood Biomarkers in Community-Dwelling Adults in the ESTHER Study

Chest

Clinical Efficacy of Serum Antiglycopeptidolipid Core IgA Antibody Test for Screening Nontuberculous Mycobacterial Pulmonary Disease in Bronchiectasis

The American Journal of Respiratory and Critical Care Medicine

Impact of the CAPTURE Chronic Obstructive Pulmonary Disease Screening Tool in U.S. Primary Care: A Cluster-Randomized Trial

Clinical Journal of American Society of Nephrology

Clinical Implications of Slope of GFR in Clinical Trials of CKD Progression

Kidney International reports

Nephrotic Syndrome Thromboprophylaxis With Direct Oral Anticoagulants or Vitamin K Antagonists

Hi, This Week in Medicine, we will be discussing

New England Journal of Medicine

Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death

Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes

A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis

Journal of American Medical Association

Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension

The KARDIA-2 Randomized Clinical Trial

Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients

The A2B Randomized Clinical Trial

Annals of Internal Medicine

Trends in Utilization of Glucose- and Weight-Lowering Medications After Tirzepatide Approval in the United States

British Medical Journal

A village doctor-led mobile health intervention for cardiovascular risk reduction in rural China

Lancet

Negative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial

journal of Hepatology

Utility of AI digital pathology as an aid for pathologists scoring fibrosis in MASH

Gastroenterology

Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease

Clinical Gastroenterology

The Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation

Rheumatology

Exploring the Association of Sociodemographic Factors and Primary Diagnosis With Transition Readiness in Adolescents With Rheumatic Disease

Journal of Clinical Rheumatology

Association of Patient Sex With Inpatient Mortality After Elective Primary Total Hip Arthroplasty for Osteoarthritis

Circulation

Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension

Journals of the American College of Cardiology

Disentangling the Impact of Adiposity From Insulin Resistance in Heart Failure With Preserved Ejection Fraction

JAMA Cardiology

Clinical Phenotype and Prognosis of Asymptomatic Patients With Transthyretin Cardiac Amyloid Infiltration

Journal of Clinical Endocrinology & Metabolism

Fetal/Maternal-Determined Birth Weight and Adulthood Type 2 Diabetes and Its Subtypes: A Mendelian Randomization Study

Neurology

Stability and Accuracy of a Diagnosis of Parkinson Disease Over 10 Years

Chest

Video vs Direct Laryngoscopy for Tracheal Intubation After Cardiac Arrest

The American Journal of Respiratory and Critical Care Medicine

Impact of the CAPTURE Chronic Obstructive Pulmonary Disease Screening Tool in U.S. Primary Care: A Cluster-Randomized Trial

Clinical Journal of American Society of Nephrology

High-Diversity Plant-Based Diet and Gut Microbiome, Plasma Metabolome, and Symptoms in Adults with CKD

Kidney International reports

Kidney Transplantation Improves Survival in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides With End-Stage Kidney Disease