Episodes

  • Challenging HSAB: Reactive Molecules and Nucleophiles

    Challenging HSAB: Reactive Molecules and Nucleophiles
    Apr 1 2025
    In this episode of Innovate and React, I am talking with Justus Reitz, a chemist from TU Dortmund University, about the limitations of the HSAB (Hard and Soft Acids and Bases) concept in predicting reaction outcomes. We explore an alternative approach using the nucleophilicity scale developed by the Mayr group, which offers a more accurate prediction method. Justus shares insights from his PhD research on stabilizing highly reactive molecules, particularly the synthesis and stabilization of diazoalkenes. We discuss how the Mayr nucleophilicity scale can facilitate understanding and controlling chemical reactions, bridging the gap between theoretical concepts and practical applications. For more check out innovateandreact.com
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    44 mins
  • Beyond Gold: Exploring Acid-Promoted Cyclization in Organic Chemistry

    Beyond Gold: Exploring Acid-Promoted Cyclization in Organic Chemistry
    Mar 18 2025
    How can we make pharmaceutical synthesis greener and more efficient? In this episode of Innovate and React, we dive into the world of organic chemistry with Dr. Nikolas Jankowski to explore an alternative to gold catalysis. While gold catalysts are known for their high selectivity and efficiency, their cost, environmental impact, and challenges in industrial applications call for new solutions. Nick shares his research on acid-promoted cyclization using hexafluoroisopropanol (HFIP) as a unique solvent, mimicking some of the effects of metal catalysts. We discuss the breakthroughs that led to a more efficient synthesis of oxazoles, molecules with promising pharmaceutical applications. Tune in as we uncover the intersection of fundamental research, reaction optimization, and the future of sustainable chemistry.
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    48 mins
  • How ion-exchange resins can make a reaction more sustainable

    How ion-exchange resins can make a reaction more sustainable
    Mar 4 2025
    Ion-exchange resins can be powerful catalysts for base catalyzed reaction such as the aldol reaction and reduce the cost and environmental impact for these reactions.
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    38 mins
  • New methods for healing bone fractures

    New methods for healing bone fractures
    Feb 16 2025
    In the future bone fractures could be glued with calcium phosphate nano particles and reduce surgery and const.
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    35 mins
  • Innovate and react Introduction

    Innovate and react Introduction
    Feb 9 2025
    This Episode give a short introduction into the future content of the podcast. For more informations visit www.innovateandreact.com, where you will find all episode and additional content for each episode.
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    3 mins