Drs Trisha Suppes and Scott T. Aaronson discuss rapid-acting therapies for bipolar disorder and the future of psychedelics and neuromodulation in its treatment.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999802. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Bipolar Disorder https://emedicine.medscape.com/article/286342-overview

The Effects of Vagus Nerve Stimulation on the Course and Outcomes of Patients With Bipolar Disorder in a Treatment-Resistant Depressive Episode: A 5-Year Prospective Registry https://pubmed.ncbi.nlm.nih.gov/32358769/

A 5-Year Observational Study of Patients With Treatment-Resistant Depression Treated With Vagus Nerve Stimulation or Treatment as Usual: Comparison of Response, Remission, and Suicidality https://pubmed.ncbi.nlm.nih.gov/28359201/

c-Fos and pERK, Which Is a Better Marker for Neuronal Activation and Central Sensitization After Noxious Stimulation and Tissue Injury? https://pubmed.ncbi.nlm.nih.gov/19898681/

Repetitive Transcranial Magnetic Stimulation in the Treatment of Bipolar Disorder https://pubmed.ncbi.nlm.nih.gov/33282175/

Efficacy of Active vs Sham Intermittent Theta Burst Transcranial Magnetic Stimulation for Patients With Bipolar Depression: A Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/33710288/

A Retrospective Analysis of Bipolar Depression Treated With Transcranial Magnetic Stimulation https://pubmed.ncbi.nlm.nih.gov/33169946/

When to Hold and When to Fold: Early Prediction of Nonresponse to Transcranial Magnetic Stimulation in Major Depressive Disorder https://pubmed.ncbi.nlm.nih.gov/38458381/

Dosing Transcranial Magnetic Stimulation in Major Depressive Disorder: Relations Between Number of Treatment Sessions and Effectiveness in a Large Patient Registry https://pubmed.ncbi.nlm.nih.gov/37827360/

Sequenced Treatment Alternatives to Relieve Depression (STAR*D): Rationale and Design https://pubmed.ncbi.nlm.nih.gov/15061154/

Single-Dose Synthetic Psilocybin With Psychotherapy for Treatment-Resistant Bipolar Type II Major Depressive Episodes: A Nonrandomized Controlled Trial https://pubmed.ncbi.nlm.nih.gov/38055270/