• AI 🤝 Genomics | GeneDx CEO Katherine Stueland
    Nov 25 2024

    Technology is transforming genetic testing and bringing hope to families facing rare diseases. In this episode, GeneDx (Nasdaq: WGS) CEO Katherine Stuhlin sits down with Steve Kraus to share how AI is being used to crack life's most complex code and speed up diagnosis from years to days.

    We cover:

    🧬 The evolution from single-gene testing (remember BRCA?) to whole genome sequencing, and why the Supreme Court's decision to ban gene patents changed everything

    🔬 How 1 in 10 Americans has a rare disease, yet the path to diagnosis traditionally takes 6-8 years

    💪 How parents become "honorary PhDs" in their children's rare conditions and how this drives research forward

    🤖 With only 1,500 medical geneticists nationwide, AI can help bridge the expertise gap

    💰 The shifting landscape of insurance coverage and why states are starting to see the value of early genetic diagnosis

    📊 How GeneDx built the world's largest rare disease database (700,000 clinical exomes and counting) and what that means for future drug development

    👩‍💼 Katherine's journey from communications major to CEO, and why having more women leaders matters in healthcare

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    Shortcuts:

    00:00 Introduction and Overview

    01:29 Advancing Diagnoses for Rare Diseases

    06:33 The Evolution of Genetic Testing

    10:44 The Cost and Coverage of Genetic Testing

    21:55 The Role of AI in Genomics and Genetic Testing

    29:43 From Communications to CEO: Katherine's Journey

    35:23 Promoting Gender Equality in the C-Suite

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    About our guest:

    Katherine Stueland has dedicated her career to revolutionizing healthcare with patient-centered business approaches. Instrumental in obtaining FDA approval for breakthroughs like the first protease inhibitor for HIV/AIDS and pioneering cancer immunotherapy, she champions the integration of genomic data for precision diagnostics in rare diseases and cancer. As President and CEO of GeneDx (Nasdaq: WGS) since June 2021, she is at the forefront of transforming healthcare through the Company’s industry-leading exome and genome testing. Previously, as Chief Commercial Officer of Invitae (NYSE: NVTA), she elevated the brand to a market cap of over $6 billion.

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    30 mins
  • Right Drug, Right Dose, Right Patient | Arine Co-Founder & CEO Yoona Kim
    Nov 21 2024

    🤗 In this bonus episode, pharmacoeconomist Yoona Kim, co-founder and CEO of Arine, talks about tackling the $530 billion problem of medication mismanagement. She shares her approach to optimizing medication therapy using data science and clinical expertise.

    We cover:

    💊 The shocking scale of medication-related problems and their impact on patient health and healthcare costs

    🛢️ How data silos and time constraints in healthcare contribute to dangerous medication errors

    🌐 The use of AI and machine learning in predicting and preventing medication-related issues

    ⚖️ Balancing cost optimization with clinical appropriateness in medication recommendations

    🚧 The challenges of integrating with existing healthcare systems and winning provider trust-

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    About our guest:

    Yoona Kim is the Founder & CEO of Arine, an AI-driven SaaS platform company focused on medication intelligence that grew 100% last year, and has produced more than 33 million life-improving recommendations for over 15 million patients. Prior to Arine, she was the Head of Clinical Modeling and Analytics at Proteus Digital Health. She was responsible for health economic and clinical implementation activities for Proteus Digital Health. Her team developed health economic value propositions from strategic conceptualization to business case development to actualization in the real-world.

    Yoona holds a Bachelor's Degree from Stanford University, a PharmD with an emphasis in health policy and management from the University of California, San Francisco and a PhD in health economics and outcomes from the University of Texas at Austin.

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    25 mins
  • Heart Health in the Digital Age | Heartbeat Health Founder & CEO Dr. Jeff Wessler
    Nov 18 2024

    Despite heart disease being the leading cause of death in the United States, cardiovascular care has been an overlooked opportunity in digital health. With 1 in 3 Americans facing cardiovascular disease in their lifetime, how can innovation help turn the tide?

    In this episode, we explore heart health in the digital age with Dr. Jeff Wessler, cardiologist and founder/CEO of Heartbeat Health, the nation's largest virtual-first cardiovascular company.

    We cover:

    ⌚If we can trust cardiovascular data from wearable devices (and what doctors call “Apple Heart Syndrome”)

    🔢 The difference between “heart age” and “chronological age”

    🤨 Why he’s skeptical of the remote monitoring market

    ❣️ The impact of stress on heart health and the role of inflammation

    ⚖️ Why he believes GLP-1s are the best heart drugs that have ever existed

    🩺 Practical tips for listeners to improve their cardiovascular health (including the important but often-overlooked LPA test)

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    About our guest:

    Dr. Jeff Wessler is a Cardiologist and the Founder and CEO of Heartbeat Health, the nation's largest virtual-first cardiovascular company. Dr. Wessler graduated from Williams College, received an MPhil in public health and epidemiology from Cambridge University, and his MD from Harvard Medical School.

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    32 mins
  • What a Trump Presidency Means for Healthcare | Former U.S. CTO Aneesh Chopra
    Nov 11 2024

    Make America Healthy Again?

    It's official— Trump was elected as our 47th president and plans to use his second term to "go wild on health." For this special episode, Aneesh Chopra, former U.S. Chief Technology Officer and author of Innovative State: How New Technologies can Transform Government, joins Steve to talk about what we can expect in Trump's second term.

    We cover:

    🔮 The future of the Affordable Care Act

    💻 What a privatized version of Healthcare.gov could look like

    🤝 The potential for value-based care to thrive in a bipartisan environment

    ♀️ The challenges facing women's health and reproductive rights

    👵 How Medicare Advantage is facing significant financial and outcome challenges

    🏆 Who will be the winners and losers of the next four years

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    About our guest:

    Aneesh Chopra advocates for interoperability and data-driven approaches that help providers, payers, and employers make smarter decisions to succeed in the shift to value-based care.

    Chopra’s influence and leadership in technology includes extensive experience in the public sector. He served as the first U.S. Chief Technology Officer under the Obama Administration, where he spearheaded initiatives to modernize the nation’s healthcare system using electronic health records and health information exchanges. These efforts strengthened the data infrastructure used in healthcare delivery reform, ultimately helping the industry progress toward a more connected and efficient healthcare ecosystem.

    Chopra also served as Virginia’s Secretary of Technology under Governor Tim Kaine, where he championed the growth of the state’s technology sector, enhanced educational opportunities through technology, and drove innovation in government operations. As a public servant, Aneesh fostered better public-private collaboration, a theme central to his 2014 book, “Innovative State: How New Technologies Can Transform Government.”

    Chopra’s significant contributions to the fields of technology and healthcare have cemented his reputation as a forward-thinking leader committed to leveraging technology for the public good. He’s been recognized by Modern Healthcare as one of the 100 Most Influential People in Healthcare and one of the top 25 "Doers, Dreamers, and Drivers” by Government Technology magazine.

    Chopra serves on the boards of IntegraConnect, Virginia Center for Health Innovation, and the George Mason Innovation Advisory Council. He earned his master’s degree in public policy from Harvard Kennedy School and holds a bachelor’s degree in health policy from Johns Hopkins University.

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    35 mins
  • 📢 Digital Health Download: November 2024
    Nov 4 2024

    Keep up with healthcare news in under an hour with our monthly Digital Health Download! We can't believe it's already November. In this episode, we cover the biggest headlines of October:

    📝 Findings from Bessemer's State of Health Tech 2024 Report

    🤝 Take-aways from the 2024 HLTH Conference

    📊 New “AI services as software” benchmarks

    😵‍💫 How election season is causing stress and anxiety

    ⚖️ New data on cost savings for ACOs

    💊 Walmart plans to deliver prescriptions in as little as 30

    💻 Oracle replacing Cerner with a new AI health record

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    31 mins
  • How Do You Feel? | Dr. Jessi Gold and Dr. Aparna Atluru
    Oct 28 2024

    Doctors are not okay. Nearly half of physicians in the United States experienced burnout in 2023, leading to absenteeism, reduced productivity, turnover, and many leaving the profession altogether. In this episode, we discuss the clinician burnout and mental health crises with two expert guests: Dr. Jessie Gold, the first chief wellness officer for the University of Tennessee System and author of "How Do You Feel? One Doctor's Search for Humanity in Medicine," and Dr. Aparna Atluru, co-founder and chief medical officer of Marvin, a company that provides specialized mental health care for healthcare workers.

    We cover:

    😮‍💨 The definition and symptoms of burnout, and if we should add it to the DSM

    👩‍⚕️ Gender disparities in physician mental health and suicide rates

    💻 The impact of technology on clinician well-being

    ✍️ Personal experiences with burnout and mental health struggles in medicine

    💡 Potential solutions and interventions, including specialized mental health care for healthcare workers

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    You can learn more about Marvin at MeetMarvin.com.

    You can learn more about Dr. Gold's work and buy her new book on DrJessiGold.com.

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    Heart of Healthcare website: https://www.heartofhealthcarepodcast.com/

    LinkedIn: https://www.linkedin.com/company/the-heart-of-healthcare-podcast?

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    39 mins
  • The Youth Mental Health Crisis | Brightline Co-Founder & CEO Naomi Allen
    Oct 21 2024

    Approximately one in five American children have a mental health condition, with many more at risk for developing one. In this episode, Halle Tecco and Michael Esquivel dive deep into the youth mental health crisis with Naomi Allen, co-founder and CEO of Brightline.

    We cover:

    📲 How technology has worsened the youth mental health crisis and how it can help solve it

    🧭 Key drivers of the crisis

    🏡 “Families are comorbid”: Family-centered care approaches in pediatric behavioral health

    ⚕️ The challenge of over-pathologizing vs. providing appropriate care

    💡 Strategies for parents to manage children's technology use

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    You can learn more about Brightline at hellobrightline.com.

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    🫶 If you're enjoying the show, please leave us a review!

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    Heart of Healthcare website: https://www.heartofhealthcarepodcast.com/

    LinkedIn: https://www.linkedin.com/company/the-heart-of-healthcare-podcast?

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    37 mins
  • The VC Playbook | Venrock's Bryan Roberts
    Oct 14 2024

    In this episode, Bryan Roberts, a partner at Venrock and one of the healthcare industry's most illustrious investors, shares insights from his 25+ year career.

    We cover:

    • The traits that have contributed to his success in healthcare investing
    • How to navigate investment cycles and make non-consensus decisions
    • Bryan's early investments in Illumina and Athena Health
    • The current state of digital health and value-based care
    • The potential impact of AI on healthcare efficiency and clinical practice
    • Exits and IPOs in the current market
    • Lessons from Bryan's biggest misses


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    36 mins