• 11 25 2024
    Nov 25 2024

    Hi, This Week in Medicine, we will be discussing

    in New England Journal of Medicine

    Nationwide, Couple-Based Genetic Carrier Screening


    Adjunctive Middle Meningeal Artery Embolization for Subdural Hematoma


    Safety and Efficacy of Immunization with a Late-Liver-Stage Attenuated Malaria Parasite


    Journal of American Medical Association

    Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores

    Zerlasiran—A Small-Interfering RNA Targeting Lipoprotein(a): A Phase 2 Randomized Clinical Trial

    Annals of Internal Medicine


    The Effect of Denosumab on Risk for Emergently Treated Hypocalcemia by Stage of Chronic Kidney Disease


    British Medical Journal

    Nurse and doctor turnover and patient outcomes in NHS acute trusts in England

    Lancet

    Induced pluripotent stem-cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human interventional study in Japan

    Cancer Journal for Clinicians

    Efficacy and safety of nivolumab monotherapy in patients with unresectable clear cell sarcoma and alveolar soft part sarcoma

    Journal of Clinical Oncology

    Trastuzumab Deruxtecan in Advanced Solid Tumors With Human Epidermal Growth Factor Receptor 2 Amplification Identified by Plasma Cell-Free DNA Testing: A Multicenter, Single-Arm, Phase II Basket Trial

    Hepatology

    Sodium taurocholate cotransporting polypeptide (NTCP) polymorphisms may influence HDV RNA load and early response to bulevirtide

    Hepatic venous pressure gradient predicts risk of hepatic decompensation and liver-related mortality in patients with MASLD

    Gastroenterology

    Molecular Mechanisms Underlying Loss of Vascular and Epithelial Integrity in Irritable Bowel Syndrome

    Clinical Gastroenterology

    Prevalence and Determinants of Liver Disease in Relatives of Italian Patients With Advanced MASLD

    Clinical Infectious Diseases


    Prevalence, Clinical Severity, and Serotype Distribution of Pneumococcal Pneumonia Among Adults Hospitalized With Community-Acquired Pneumonia in Tennessee and Georgia, 2018–2022

    Rheumatology

    Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis

    Journal of Clinical Rheumatology

    Prevalence and Clinical Implications of Autoantibodies in Juvenile Dermatomyositis: A Single-Center Experience From India

    Circulation

    Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction

    Journals of the American College of Cardiology


    Complete vs Culprit-Only Revascularization in Older Patients With Myocardial Infarction With or Without ST-Segment Elevation

    JAMA Cardiology

    Verinurad Plus Allopurinol for Heart Failure With Preserved Ejection FractionThe AMETHYST Randomized Clinical Trial


    Journal of Clinical Endocrinology & Metabolism


    Hemostatic Effects of Exercise-related Hypoglycemia in Male Persons With Type 1 Diabetes

    Diabetes care

    Trends in Racial and Ethnic Disparities in Early Glycemic Control Among Veterans Receiving Care in the Veterans Health Administration, 2008–2019

    Neurology

    Quantitative MRI Measures and Cognitive Function in People With Drug-Resistant Juvenile Myoclonic Epilepsy



    Chest

    Air Pollution Metabolomic Signatures and Chronic Respiratory Diseases Risk

    A Longitudinal Study

    The American Journal of Respiratory and Critical Care Medicine


    Lung-Protective Mechanical Ventilation in Patients with Severe Acute Brain Injury: A Multicenter Randomized Clinical Trial (PROLABI)


    Clinical Journal of American Society of Nephrology

    Physical Function and Mortality in Older Adults with Chronic Kidney Disease

    Kidney International reports


    Associations of Urine Epidermal Growth Factor With Kidney and Cardiovascular Outcomes in Individuals With CKD in SPRINT




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    26 mins
  • 11 18 2024
    Nov 18 2024

    Hi, This Week in Medicine, we will be discussing


    New England Journal of Medicine

    Perioperative Durvalumab with Neoadjuvant Chemotherapy in Operable Bladder Cancer


    Transcatheter Repair versus Mitral-Valve Surgery for Secondary Mitral Regurgitation


    Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation


    Preoperative Chemoradiotherapy for Resectable Gastric Cancer

    Journal of American Medical Association

    Symptom Screening Linked to Care Pathways for Pediatric Patients With Cancer: A Randomized Clinical Trial

    Tenofovir and Hepatitis B Virus Transmission During Pregnancy

    Symptom Screening Linked to Care Pathways for Pediatric Patients With Cancer

    Annals of Internal Medicine


    Association Between False-Positive Results and Return to Screening Mammography in the Breast Cancer Surveillance Consortium Cohort

    British Medical Journal

    SGLT-2 inhibitors and mortality among patients with heart failure with reduced ejection fraction


    Malnutrition in infants aged 6-23 months in China’s poorest rural counties from 2016 to 2021

    Lancet


    Genetic sequencing analysis of monkeypox virus clade I in Republic of the Congo: a cross-sectional, descriptive study

    Cancer Journal for Clinicians

    Comparison of infection risk between enzalutamide and abiraterone in patients with prostate cancer

    Journal of Clinical Oncology

    Stockholm3 in a Multiethnic Cohort for Prostate Cancer Detection (SEPTA): A Prospective Multicentered Trial

    Hepatology

    CRISPR-Cas13b-mediated suppression of HBV replication and protein expression

    Epigenetic scars in regulatory T cells are retained after successful treatment of chronic hepatitis C with direct-acting antivirals

    Gastroenterology

    The Global Incident Gastrointestinal Cancers Attributable to Suboptimal Diets From 1990 to 2018

    Clinical Gastroenterology

    The Efficacy of Real-time Computer-aided Detection of Colonic Neoplasia in Community Practice: A Pragmatic Randomized Controlled Trial

    Clinical Infectious Diseases

    Preventing New Gram-negative Resistance Through Beta-lactam De-escalation in Hospitalized Patients With Sepsis: A Retrospective Cohort Study

    Rheumatology

    Gout Flare Burden in the United States: A Multiyear Cross‐Sectional Survey Study

    Journal of Clinical Rheumatology

    Development and Validation of Nosocomial Bacterial Infection Prediction Models for Patients With Systemic Lupus Erythematosus

    Circulation

    Complete Versus Culprit-Only Revascularization in Older Patients With ST-Segment–Elevation Myocardial Infarction: An Individual Patient Meta-Analysis

    Journals of the American College of Cardiology


    Comprehensive Proteomic Profiling of Human Myocardium Reveals Signaling Pathways Dysregulated in Hypertrophic Cardiomyopathy

    JAMA Cardiology

    Prehospital Pulse-Dose Glucocorticoid in ST-Segment Elevation Myocardial InfarctionThe PULSE-MI Randomized Clinical Trial

    Journal of Clinical Endocrinology & Metabolism


    Medullary Thyroid Cancer: Single Institute Experience Over 3 Decades and Risk Factors for Recurrence

    Diabetes care

    Development of a Core Outcome Set for Studies Assessing Interventions for Diabetes-Related Foot Ulceration

    Neurology

    Identification of Genetic Loci Associated With Intracerebral Hemorrhage Using a Multitrait Analysis Approach

    Chest


    Sex Differences After Treatment With Ivacaftor in People With Cystic Fibrosis



    The American Journal of Respiratory and Critical Care Medicine


    Low-Dose Morphine Does Not Cause Sleepiness in Chronic Obstructive Pulmonary Disease: A Secondary Analysis of a Randomized Clinical Trial

    Clinical Journal of American Society of Nephrology

    Association between Chronic Kidney Disease-Mineral and Bone Disorder Biomarkers and Symptom Burden in Older Patients with Advanced Chronic Kidney Disease: Results from the EQUAL Study



    Kidney International reports

    IMPACT CKD: Holistic Disease Model Projecting 10-Year Population Burdens




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    29 mins
  • 11 7 2024
    Nov 11 2024

    Hi, This Week in Medicine, we will be discussing

    New England Journal of Medicine

    Invasive Treatment Strategy for Older Patients with Myocardial Infarction

    Randomized Trial of Very Early Medication Abortion


    Neoadjuvant Nivolumab and Ipilimumab in Resectable Stage III Melanoma


    Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma


    Journal of American Medical Association

    Postmarketing Surveillance of Inferior Vena Cava Filters Among US Medicare Beneficiaries

    The SAFE-IVC Study

    A Digital Health Behavior Intervention to Prevent Childhood Obesity

    The Greenlight Plus Randomized Clinical Trial


    Annals of Internal Medicine

    Ensuring Safe Practice by Late Career Physicians: Institutional Policies and Implementation Experiences

    British Medical Journal

    SGLT-2 inhibitors and mortality among patients with heart failure with reduced ejection fraction

    Lancet


    Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial

    Cancer Journal for Clinicians

    Epidemiology, treatment patterns, and clinical outcomes in de novo oligometastatic hormone-sensitive prostate cancer

    Journal of Clinical Oncology

    Addition of Metastasis-Directed Therapy to Systemic Therapy for Oligometastatic Pancreatic Ductal Adenocarcinoma (EXTEND): A Multicenter, Randomized Phase II Trial

    journal of Hepatology

    Diagnostic performance of non-invasive tests in patients with MetALD in a health check-up cohort

    Histological improvements following energy restriction and exercise: The role of insulin resistance in resolution of MASH

    Gastroenterology

    Gluten-Dependent Activation of CD4+ T Cells by MHC Class II–Expressing Epithelium

    Clinical Gastroenterology

    Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial

    Clinical Infectious Diseases

    Successful Treatment of Carbapenem-Resistant Acinetobacter baumannii Meningitis With Sulbactam-Durlobactam

    Rheumatology

    Comprehensive Enteroviral Serology Links Infection and Anti‐Melanoma Differentiation‐Associated Protein 5 Dermatomyositis

    Journal of Clinical Rheumatology

    Factors Associated With Successful Withdrawal of Biologic Agents in Children With Colchicine-Resistant Familial Mediterranean Fever

    Circulation

    Contemporary Outcomes and Trends for the Transseptal Mitral Valve-in-Valve Procedure Using Balloon Expandable Transcatheter Valves in the United States

    Journals of the American College of Cardiology


    Reaffirmation of Mechanistic Proteomic Signatures Accompanying SGLT2 Inhibition in Patients With Heart Failure: A Validation Cohort of the EMPEROR Program

    Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure

    Journal of Clinical Endocrinology & Metabolism


    Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas

    Diabetes care

    Health Care Utilization and Costs Associated With Empagliflozin in Older Adults With Type 2 Diabetes

    Neurology

    Frequency and Longitudinal Course of Behavioral and Neuropsychiatric Symptoms in Participants With Genetic Frontotemporal Dementia

    Chest

    Primary Ciliary Dyskinesia in Adult Bronchiectasis

    American Journal of Respiratory and Critical Care Medicine

    Discovery and Validation of a Volatile Signature of Eosinophilic Airway Inflammation in Asthma

    Clinical Journal of American Society of Nephrology

    Urine Output and Acute Kidney Injury in Neonates/Younger Children: A Prospective Study of Cardiac Surgery Patients with Indwelling Urinary Catheters


    Large Discordance between Creatinine-Based and Cystatin C–Based eGFRs is Associated with Falls, Hospitalizations, and Death in Older Adults

    Kidney International reports

    Systematic Review of Individual Patient Data COVID-19 Infection and Vaccination–Associated Thrombotic Microangiopathy




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    38 mins
  • 11 4 2024
    Nov 4 2024

    Hi, This Week in Medicine, we will be discussing

    New England Journal of Medicine

    Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis

    Inavolisib-Based Therapy in PIK3CA-Mutated Advanced Breast Cancer



    Isatuximab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma


    Total Hip Replacement or Resistance Training for Severe Hip Osteoarthritis


    from Journal of American Medical Association

    Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis

    The EVOLVED Randomized Clinical Trial

    Annals of Internal Medicine


    Projected Impact and Cost-Effectiveness of Novel Molecular Blood-Based or Stool-Based Screening Tests for Colorectal Cancer

    Comparative Effectiveness and Safety of Atorvastatin Versus Rosuvastatin: A Multi-database Cohort Study

    British Medical Journal

    Comparative effectiveness of sodium-glucose cotransporter-2 inhibitors for recurrent nephrolithiasis among patients with pre-existing nephrolithiasis or gout: target trial emulation studies

    Lancet

    The effect of tranexamic acid on postpartum bleeding in women with moderate and severe anaemia (WOMAN-2): an international, randomised, double-blind, placebo-controlled trial

    Journal of Clinical Oncology

    Randomized Phase II Trial of Immunotherapy-Based Total Neoadjuvant Therapy for Proficient Mismatch Repair or Microsatellite Stable Locally Advanced Rectal Cancer (TORCH)

    journal of Hepatology

    Histological improvements following energy restriction and exercise: The role of insulin resistance in resolution of MASH

    Gastroenterology

    A Single-Cell Atlas of the Murine Pancreatic Ductal Tree Identifies Novel Cell Populations With Potential Implications in Pancreas Regeneration and Exocrine Pathogenesis



    Fazirsiran for Adults With Alpha-1 Antitrypsin Deficiency Liver Disease: A Phase 2 Placebo Controlled Trial (SEQUOIA)


    Clinical Infectious Diseases



    Evidence-Informed Provision of Doxycycline Post-Exposure Prophylaxis for Prevention of Bacterial Sexually Transmitted Infections

    Abstract

    Rheumatology

    Implementing Patient Health Questionnaire Depression Screening in Inflammatory Arthritis Clinic: Insights From a Quality Improvement Project at a Tertiary Rheumatology Center

    Circulation

    RNA Helicase DDX5 Maintains Cardiac Function by Regulating CamkIIδ Alternative Splicing

    Journals of the American College of Cardiology

    Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis

    JAMA Cardiology

    Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure

    Journal of Clinical Endocrinology & Metabolism

    Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas

    Diabetes care

    Sitting Time and Its Interaction With Physical Activity in Relation to All-Cause and Heart Disease Mortality in U.S. Adults With Diabetes



    The American Journal of Respiratory and Critical Care Medicine


    The Effect of Positive End-Expiratory Pressure on Pulmonary Vascular Resistance Depends on Lung Recruitability in Patients with Acute Respiratory Distress Syndrome

    Rationale: A U-shaped relationship should exist between lung volume and Kidney International reports



    Prospective Trial on the Pharmacokinetics of Clopidogrel in Hemodialysis Patients

    A Survey on End-of-Life Contemplation Among Patients on Dialysis




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    32 mins
  • 10 28 2024
    Oct 28 2024

    Hi, This Week in Medicine, we will be discussing


    New England Journal of Medicine

    Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction

    Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC


    Collagenase Injection versus Limited Fasciectomy for Dupuytren’s Contracture


    Journal of American Medical Association

    Dialysis Facility Staffing Ratios and Kidney Transplant Access Among Adolescents and Young Adults


    Expanded Newborn Screening Using Genome Sequencing for Early Actionable Conditions

    Annals of Internal Medicine


    Colorectal Cancer Screening Completion and Yield in Patients Aged 45 to 50 Years: An Observational Study

    British Medical Journal

    Association of holidays and the day of the week with suicide risk: multicounty, two stage, time series study

    Lancet

    Induction chemotherapy followed by standard chemoradiotherapy versus standard chemoradiotherapy alone in patients with locally advanced cervical cancer (GCIG INTERLACE): an international, multicentre, randomised phase 3 trial

    Journal of Clinical Oncology

    Social Characteristics and Adherence to Adjuvant Endocrine Therapy in Premenopausal Women With Breast Cancer

    journal of Hepatology

    Diagnostic performance of non-invasive tests in patients with MetALD in a health check-up cohort

    Gastroenterology

    Effect of Brain-Gut Behavioral Treatments on Abdominal Pain in Irritable Bowel Syndrome: Systematic Review and Network Meta-Analysis

    Targeting 5-Hydroxytryptamine Receptor 1A in the Portal Vein to Decrease Portal Hypertension

    Clinical Gastroenterology

    Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial

    Clinical Infectious Diseases


    Comparative safety of different antibiotic regimens for the treatment of outpatient community-acquired pneumonia among otherwise healthy adults

    Journal of Clinical Rheumatology


    Factors Associated With Successful Withdrawal of Biologic Agents in Children With Colchicine-Resistant Familial Mediterranean Fever

    Circulation


    Novel Long Noncoding RNA HEAT4 Affects Monocyte Subtypes, Reducing Inflammation and Promoting Vascular Healing

    Journals of the American College of Cardiology

    Heart Failure Risk Assessment Using Biomarkers in Patients With Atrial Fibrillation: Analysis From COMBINE-AF

    Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure

    Journal of Clinical Endocrinology & Metabolism


    Obesity, Inflammation, and Clinical Outcomes in COVID-19: A Multicenter Prospective Cohort Study

    Diabetes care

    Empowering Hospitalized Patients With Diabetes: Implementation of a Hospital-wide CGM Policy With EHR-Integrated Validation for Dosing Insulin

    Use of Financial Incentives to Promote Adolescent Type 1 Diabetes Self-management: A Pilot Randomized Controlled Trial

    Neurology

    Frequency and Longitudinal Course of Behavioral and Neuropsychiatric Symptoms in Participants With Genetic Frontotemporal Dementia

    Chest

    Characteristics of Adults With Severe Asthma in Childhood

    A 60-Year Follow-Up Study

    The American Journal of Respiratory and Critical Care Medicine


    Genetically Predicted Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease


    Clinical Journal of American Society of Nephrology

    Urine Output and Acute Kidney Injury in Neonates/Younger Children: A Prospective Study of Cardiac Surgery Patients with Indwelling Urinary Catheters

    Kidney International reports


    Elevated Ambient Temperature Associated With Increased Cardiovascular Disease–Risk Among Patients on Hemodialysis


    Lower Parathyroid Hormone Levels are Associated With Reduced Fracture Risk in Japanese Patients on Hemodialysis




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    37 mins
  • 10 21 2024
    Oct 21 2024

    Hi, This Week in Medicine, we will be discussing

    New England Journal of Medicine

    Nivolumab+AVD in Advanced-Stage Classic Hodgkin’s Lymphoma

    Safety of Kidney Transplantation from Donors with HIV

    A Modular Communicative Leadless Pacing–Defibrillator System

    Phase 3 Trial of Stereotactic Body Radiotherapy in Localized Prostate Cancer

    Journal of American Medical Association

    Testing and Evaluation of Health Care Applications of Large Language Models

    A Systematic Review

    Annals of Internal Medicine

    School Mask Mandates and COVID-19: The Challenge of Using Difference-in-Differences Analysis of Observational Data to Estimate the Effectiveness of a Public Health Intervention

    British Medical Journal

    Paternal metformin use and risk of congenital malformations in offspring in Norway and Taiwan: population based, cross national cohort study

    Progress of nations in the organisation of, and structures for, kidney care delivery between 2019 and 2023: cross sectional survey in 148 countries


    Lancet


    Reductions in recurrence in women with early breast cancer entering clinical trials between 1990 and 2009: a pooled analysis of 155 746 women in 151 trials

    Journal of Clinical Oncology

    Human Leukocyte Antigen Mismatching and Survival in Contemporary Hematopoietic Cell Transplantation for Hematologic Malignancies

    journal of Hepatology

    Diagnostic performance of non-invasive tests in patients with MetALD in a health check-up cohort

    Gastroenterology

    Subcutaneous Infliximab (CT-P13 SC) as Maintenance Therapy for Inflammatory Bowel Disease: Two Randomized Phase 3 Trials (LIBERTY)

    Prognostic Factors for Early Recurrence After Resection of Pancreatic Cancer: A Systematic Review and Meta-Analysis

    Clinical Infectious Diseases

    Successful Treatment of Carbapenem-Resistant Acinetobacter baumannii Meningitis With Sulbactam-Durlobactam

    Rheumatology

    Leveraging Habits to Improve Adherence to Gout Medications: A Qualitative Study

    Journal of Clinical Rheumatology

    Development and Validation of Nosocomial Bacterial Infection Prediction Models for Patients With Systemic Lupus Erythematosus

    Circulation

    Neurofilament Light Chain and Risk of Stroke in Patients With Atrial Fibrillation

    Journals of the American College of Cardiology


    Bivalirudin vs Heparin Anticoagulation in STEMI: Confirmation of the BRIGHT-4 Results

    JAMA Cardiology


    Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure

    Journal of Clinical Endocrinology & Metabolism


    Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas

    Diabetes care

    Discrepancy Between Genetically Predicted and Observed BMI Predicts Incident Type 2 Diabetes

    Associations of High BMI and Excessive Gestational Weight Gain With Pregnancy Outcomes in Women With Type 1 Diabetes

    Neurology

    Association of Polygenic Risk Score With Lifetime Risk of Developing Multiple Sclerosis in a Population-Based Birth-Year Cohort

    Chest

    Characteristics of Adults With Severe Asthma in Childhood

    The American Journal of Respiratory and Critical Care Medicine

    Impact of Using Pre- and Postbronchodilator Spirometry Reference Values in a Chinese Population

    Clinical Journal of American Society of Nephrology

    Urine Output and Acute Kidney Injury in Neonates/Younger Children: A Prospective Study of Cardiac Surgery Patients with Indwelling Urinary Catheters

    Kidney International reports


    Imlifidase in Highly Sensitized Kidney Transplant Recipients With a Positive Crossmatch Against a Deceased Donor


    Losing Much More Than a Transplant: A Qualitative Study of Kidney Transplant Recipients’ Experiences of Graft Failure




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    47 mins
  • 10 14 2024
    Oct 14 2024

    New England Journal of Medicine

    Beta-Blocker Interruption or Continuation after Myocardial Infarction


    Hematologic Cancer after Gene Therapy for Cerebral Adrenoleukodystrophy

    Lentiviral Gene Therapy for Cerebral Adrenoleukodystrophy


    Durvalumab after Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer


    Journal of American Medical Association

    Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial


    Extracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery: The SIRAKI02 Randomized Clinical Trial

    Annals of Internal Medicine


    Pain Reduction With Oral Methotrexate in Knee Osteoarthritis


    British Medical Journal

    Rainfall events and daily mortality across 645 global locations


    Lancet



    Tivozanib plus nivolumab versus tivozanib monotherapy in patients with renal cell carcinoma following an immune checkpoint inhibitor: results of the phase 3 TiNivo-2 Study



    Effects of oral sepiapterin on blood Phe concentration in a broad range of patients with phenylketonuria (APHENITY): results of an international, phase 3, randomised, double-blind, placebo-controlled trial


    Journal of Clinical Oncology

    Post-Transplant Cyclophosphamide–Based Graft-Versus-Host Disease Prophylaxis Attenuates Disparity in Outcomes Between Use of Matched or Mismatched Unrelated Donors

    Gastroenterology


    WNT Oncogenic Transcription Requires MYC Suppression of Lysosomal Activity and EPCAM Stabilization in Gastric Tumors



    Organoids for Functional Precision Medicine in Advanced Pancreatic Cancer


    Journal of Clinical Rheumatology

    Factors Associated With Successful Withdrawal of Biologic Agents in Children With Colchicine-Resistant Familial Mediterranean Fever

    Circulation


    Relationship of Subendocardial Perfusion to Myocardial Injury, Cardiac Structure, and Clinical Outcomes Among Patients With Hypertension

    Journals of the American College of Cardiology

    Minimum National Prevalence of Diagnosed Atrial Fibrillation Inferred From California Acute Care Facilities


    Diabetes care

    Hemoglobin A1c Genetics and Disparities in Risk of Diabetic Retinopathy in Individuals of Genetically Inferred African American/African British and European Ancestries

    Comprehensive Multiple Risk Factor Control in Type 2 Diabetes to Mitigate Heart Failure Risk: Insights From a Prospective Cohort Study

    The American Journal of Respiratory and Critical Care Medicine


    Exploring Definitions and Predictors of Severe Asthma Clinical Remission after Biologic Treatment in Adults


    Kidney International reports


    Clinical Outcomes of a Novel Multidisciplinary Care Program in Advanced Kidney Disease (PEAK)


    Bringing a Systems Approach to Living Donor Kidney Transplantation




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    32 mins
  • 10 7 2024
    Oct 7 2024

    Hi, This Week in Medicine, we will be discussing


    New England Journal of Medicine

    Twice-Yearly Lenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women

    Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity

    Standard or Extended Lymphadenectomy for Muscle-Invasive Bladder Cancer

    Journal of American Medical Association

    Screening for Helicobacter pylori to Prevent Gastric Cancer

    Assessment of Antitachycardia Pacing in Primary Prevention Patients

    The APPRAISE ATP Randomized Clinical Trial

    Annals of Internal Medicine


    Time-Restricted Eating in Adults With Metabolic Syndrome: A Randomized Controlled Trial

    British Medical Journal

    Model of integrated mental health video consultations for people with depression or anxiety in primary care

    Lancet


    Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050

    journal of Hepatology

    Prospective validation of the EASL management algorithm for acute kidney injury in cirrhosis

    Gastroenterology

    Comparison of Vonoprazan Versus Intravenous Proton Pump Inhibitor for Prevention of High-Risk Peptic Ulcers Rebleeding After Successful Endoscopic Hemostasis: A Multicenter Randomized Noninferiority Trial

    Clinical Gastroenterology

    Representation of Racial Minorities in the United States Colonoscopy Surveillance Interval Guidelines

    Clinical Infectious Diseases

    Make Modern Microbiology Matter More in the 2023 European Society of Cardiology Guidelines for the Management of Infective Endocarditis

    HIV, HIV-Specific Factors, and Myocardial Disease in Women

    Arthritis and Rheumatology

    Expanded CD8+CD38+ T Cell Population in Patients With Systemic Lupus Erythematosus Is Linked to Increased Infection Rates: A Prospective Study

    Circulation


    Race and Sex Differences in the Association of Bystander CPR for Cardiac Arrest

    Journals of the American College of Cardiology

    Anticoagulation Alone vs Anticoagulation Plus Aspirin or DAPT Following Left Atrial Appendage Occlusion

    JAMA Cardiology

    Rare and Common Genetic Variation Underlying Atrial Fibrillation Risk

    Journal of Clinical Endocrinology & Metabolism

    Contralateral Suppression in Adrenal Venous Sampling Predicts Clinical and Biochemical Outcome in Primary Aldosteronism

    Diabetes care

    Long-term Neurobehavioral and Metabolic Outcomes in Offspring of Mothers With Diabetes During Pregnancy: A Large, Population-Based Cohort Study in Ontario, Canada

    Neurology

    Public Views on Whether the Use of Pharmaceutical Neuroenhancements Should Be Allowed

    Chest

    Barriers and Facilitators of Surrogates Providing Consent for Critically Ill Patients in Clinical Trials

    \

    The American Journal of Respiratory and Critical Care Medicine

    Biological Age, Chronological Age, and Survival in Pulmonary Fibrosis: A Causal Mediation Analysis

    Clinical Journal of American Society of Nephrology


    A National Survey of Pregnancy and Parenthood among Nephrology Trainees: A Focus on Nephrology Fellowship

    Kidney International reports


    APOL1 High-Risk Genotype is Not Associated With New or Worsening of Proteinuria or Kidney Function Decline Following COVID-19 Vaccination





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    34 mins