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Captain Sabine Fleischer is a skilled and dedicated US Army surgeon deployed to a combat hospital in Afghanistan. She is also one of the thousands of troops who are forced to serve in silence because of the military's anti-gay policy of "Don't Ask, Don't Tell (DADT)". Usually driven and focused, Sabine finds that battles raging both inside and outside are making it more and more difficult for her to deal with her emotions. Dealing with loss and mortality, lack of privacy, sleep deprivation, loneliness, and the isolation forced on her by Don't Ask, Don't Tell are all taking their toll.

After nearly a decade as a professional drummer, Diana Petrell leaves her rock-star life behind to continue her residency in emergency medicine. She's determined not to let anything stop her - not even falling in love with her aloof mentor, Dr. Emily Barnes. Emily has only ever focused on her career as a senior attending in the emergency department, and she isn't happy about having to babysit a resident with a 10-year gap in her resume, no matter how intriguing she is. But every time they work together, it's not just their patients' heartbeat that gets a little irregular.