Liverpool, 1940. When her childhood sweetheart, Johnny, is killed in action, Maxine Grey loses more than her husband - she loses her best friend. Desperate to make a difference in this awful war, Maxine takes a nursing job at London’s St Thomas’ hospital. She takes comfort in the attentions of a handsome surgeon, but Edwin Blake isn’t all he seems. And as the Blitz descends on the capital, Maxine faces more heartache. When she returns to Liverpool, she harbours a secret.

Liverpool, 1941. Troubled by a dark family history and the pain of seeing her country torn apart by war, young June Lavender finds new hope when she takes a job at the Dr Barnardo's children's home. There she meets Lizzie McRae, a little girl who is the spitting image of June's sister, who died tragically years before. Against the matron's wishes, the two girls form an unexpected bond as June tries to get the traumatised orphan to speak.

Alice Lake has arrived in London from Liverpool to start her training as a District Nurse, but her journey has been far from easy. Her parents think that she should settle down and get married, but she has already had her heart broken once and isn’t about to make the same mistake again. Alice and her best friend, Edith, are based in the East End, but before they’ve even got their smart new uniforms on, war breaks out, and Hitler’s bombs are raining down on London.

Three very different girls sign up as trainee nurses at a big London teaching hospital in 1934. Dora leaves her overcrowded, squalid working-class home for a better life. But has she got what it takes to keep up with other, better-educated girls? And will her hated stepfather ever let her go? Helen is born for the job; her brother is a doctor, her all-powerful mother a hospital trustee. But will Helen’s secret misery be her downfall? An aristocratic rebel, Millie’s carefree attitude will find her up in front of Matron again and again. Will she ever care enough to make a nurse? Or will she go back to the glamorous life she was born to?

When Cissy Ryan’s real mother comes to claim her from the workhouse, it’s not how she imagined. Her family’s tumbledown cottage has ice on the inside of its windows and is in an isolated, poverty-stricken village in the muddy Irish countryside. But when Cissy is allowed to help neighbour Colm Doyle and his horse named Blue on their milk round one morning, Cissy starts to feel as though friendship could get her through anything.

Mary Doyle arrives in Dublin in 1913, doomed, she fears, to a life of domestic service. Instead, however, she finds herself deeply affected by the social and political turmoil of a fledgling nation struggling for independence. Suddenly, all that was once inevitable is no longer a certainty as she is embroiled in the very heart of the Easter Rising.

East London, 1888 - a city apart. A place of shadow and light where thieves, whores, and dreamers mingle, where children play in the cobbled streets by day and a killer stalks at night, where bright hopes meet the darkest truths. Here, by the whispering waters of the Thames, Fiona Finnegan, a worker in a tea factory, hopes to own a shop one day, together with her lifelong love, Joe Bristow, a costermonger's son. With nothing but their faith in each other to spur them on, Fiona and Joe struggle, save, and sacrifice to achieve their dreams.

1913: In a sprawling manor on the outskirts of London, three young women seek to fulfill their destinies and desires amidst the unspoken rules of society and the distant rumblings of war.... Sir Philip Buxton raised three girls into beautiful and capable young women in a bohemian household that defied Edwardian tradition. Eldest sister Rowena was taught to value people, not wealth or status. But everything she believes will be tested when Sir Philip dies, and the girls must live under their uncle’s guardianship....

Summer 1924: On the eve of a glittering society party, by the lake of a grand English country house, a young poet takes his life. The only witnesses, sisters Hannah and Emmeline Hartford, will never speak to each other again. Winter 1999: Grace Bradley, 98, one-time housemaid of Riverton Manor, is visited by a young director making a film about the poet's suicide. Ghosts awaken and memories, long consigned to the dark reaches of Grace's mind, begin to sneak back through the cracks.

In 1935, Dottie Krasinsky is the epitome of the modern girl. A bookkeeper in midtown Manhattan, Dottie steals kisses from her steady beau, meets her girlfriends for drinks, and eyes the latest fashions. Yet at heart, she is a dutiful daughter, living with her Yiddish-speaking parents on the Lower East Side. So when, after a single careless night, she finds herself in a family way by a charismatic but unsuitable man, she is desperate: unwed, unsure, and running out of options.

Gervase Howard is in her mid-teens when her working-class mother dies and she must go to live with relatives in service to a wealthy, noble family, outside of London. While learning various jobs, she is drawn to the eldest son, Davis. Her fascination with him grows deeper, but more hopeless, since the two are separated not just by class, but also by Davis's love for Roberta. When Davis announces his engagement, he asks Gervase to join them as Roberta's maid. But instead Gervase becomes a companion to Florence Nightingale and accompanies her when the Crimean War breaks out....

A long-forgotten secret, a scandalous attraction and a place where two women's lives are changed forever. 1926: Violet Armstrong is one of the few remaining members of staff working at the grand Evergreen Spa Hotel as it closes down over winter. Only a handful of guests are left, including the heir to a rich grazing family, his sister and her suave suitor. When a snowstorm moves in, the hotel is cut off and they are all trapped. No-one could have predicted what would unfold.

Manzhen is a young worker in a Shanghai factory where she meets Shijun, the son of wealthy merchants. Despite family complications, they fall in love and begin to dream of a shared life together - until circumstances force them apart. When they are reunited after many years, can they start their relationship again? Or is it destined to be the romance of only half a lifetime?

Clarissa is almost 17 when the spell of her childhood is broken. It is 1914, the beginning of a blissful, golden summer - and the end of an era. Deyning Park is in its heyday, the large country house filled with the laughter and excitement of privileged youth preparing for a weekend party. When Clarissa meets Tom Cuthbert, home from university and staying with his mother, the housekeeper, she is dazzled.

After four years as a military nurse, Charlotte Brown is ready to leave behind the devastation of the Great War. The daughter of a vicar, she has always been determined to dedicate her life to helping others. Moving to busy Liverpool, she throws herself into her work with those most in need, only tearing herself away for the lively dinners she enjoys with the women at her boardinghouse.