Happiness begins with a charming courtship between hopelessly attracted opposites: Heather, a world-roaming California girl, and Brian, an intellectual, homebody writer, kind and slyly funny, but loath to leave his Upper West Side studio. Their magical interlude ends, full stop, when Heather becomes pregnant - Brian is sure he loves her, only he doesn't want kids. Heather returns to California to deliver their daughter alone, buoyed by family and friends.

The number-one New York Times best-selling author of Small Great Things returns with a powerful and provocative new novel about ordinary lives that intersect during a heart-stopping crisis. The warm fall day starts like any other at the Center - a women’s reproductive health services clinic. Then, in late morning, a desperate and distraught gunman bursts in and opens fire, taking all inside hostage. After rushing to the scene, Hugh McElroy, a police hostage negotiator, sets up a perimeter. Then he finds out that his 15-year-old daughter, Wren, is inside the clinic.

At 28, Stephanie Land's dreams of attending a university and becoming a writer quickly dissolved when a summer fling turned into an unplanned pregnancy. Before long, she found herself a single mother, scraping by as a housekeeper to make ends meet. Maid is an emotionally raw, masterful account of Stephanie's years spent in service to upper-middle-class America as a "nameless ghost" who quietly shared in her clients' triumphs, tragedies, and deepest secrets.

Anna is not sick, but she might as well be. By age 13 she has undergone countless surgeries, transfusions, and shots so that her older sister, Kate, can somehow fight the leukemia that has plagued her since childhood. The product of preimplantation genetic diagnosis, Anna was conceived as a bone marrow match for Kate - a life and a role that she has never challenged...until now. Like most teenagers, Anna is beginning to question who she truly is.

When Carly Sears, a young woman widowed by the Vietnam War, receives the news that her unborn baby girl has a heart defect, she is devastated. It is 1970, and she is told nothing can be done to help her child. But her brother-in-law, a physicist with a mysterious past, tells her that perhaps there is a way to save her baby. What he suggests is something that will shatter every preconceived notion Carly has. Something that will require a kind of strength and courage she never knew existed. Something that will mean an unimaginable leap of faith on Carly's part.

Even as a reporter, Sheila Hamilton missed the signs as her husband David's mental illness unfolded before her. By the time she had pieced together the puzzle, it was too late.

In a candid and witty memoir, Jodi recounts how her life was transformed when, as a 33-year-old wife and mother, she was diagnosed with an inoperable brain tumor. Unwilling to accept her new fate, Jodi's family searches for a doctor who will join their fight against the odds.

After being diagnosed in her early forties with metastatic melanoma - a "rapidly fatal" form of cancer - journalist and mother of two Mary Elizabeth Williams finds herself in a race against the clock. She takes a once-in-a-lifetime chance and joins a clinical trial for immunotherapy, a revolutionary drug regimen that trains the body to vanquish malignant cells. Astonishingly, her cancer disappears entirely in just a few weeks. But at the same time, her best friend embarks on a cancer journey of her own - with very different results.

Written by Deborah Ziegler, the mother of Brittany Maynard - a 29-year-old woman with a terminal brain tumor - this touching and beautiful memoir captures and celebrates her daughter's spirit and the mostly untold story of Brittany's last year of life as she chose her right to die with dignity, a journey that inspired millions.

Every expectant parent will tell you that they don't want a perfect baby, just a healthy one. Charlotte and Sean O'Keefe would have asked for a healthy baby, too, if they'd been given the choice. Instead their lives are made up of sleepless nights, mounting bills, the pitying stares of "luckier" parents, and, maybe worst of all, the what-ifs.

Heather is pale and thin, seventeen and pregnant with twins when Patricia Harman begins to care for her. Over the course of the next five seasons Patsy will see Heather through the loss of both babies and their father. She will also care for her longtime patient Nila, pregnant for the eighth time and trying to make a new life without her abusive husband. And Patsy will try to find some comfort to offer Holly, whose teenage daughter struggles with bulimia. She will help Rebba learn to find pleasure in her body and help Kaz transition into a new body.

Dr. Julie Walker wakes on a summer morning in San Francisco to find a city in chaos. Today Californians are voting on a controversial ballot initiative that will change history. With the future of the state and the nation uncertain, the streets have erupted into violence. Injured, Julie must make her way across the city by foot to the Veterans Administration Hospital, where her sister, recently returned from Afghanistan, is in labor. At the hospital a brutal scene is unfolding as a man who shares an intimate past with Julie begins to take his revenge.

As a daughter, mother, and friend, Mary Laura Philpott considered herself an “anxious optimist”—a natural worrier with a stubborn sense of good cheer. And while she didn’t really think she had any sort of magical protective powers, she believed in her heart that as long as she loved her people enough, she could keep them safe.

Sicily Coyne was just thirteen when her father was killed in a school fire that left her face disfigured. Twelve years later, a young surgeon, Eliza Cappadora, offers hope in the form of a revolutionary new surgery that may give Sicily back the grace and function she lost. Raised by a dynamic, tenacious aunt who taught her to lead a normal life, and engaged to a wonderful man who knew her long before the accident, Sicily rejects the offer: She knows who she is, and so do the people who love her.

Clare Dunkle seemed to have an ideal life - two beautiful, high-achieving teenage daughters, a loving husband, and a satisfying and successful career as a children's book novelist. But it's when you let down your guard that the ax falls. Just after one daughter successfully conquered her depression, another daughter developed a life-threatening eating disorder.

Heather is pale and thin, seventeen and pregnant with twins when Patricia Harman begins to care for her. Over the course of the next five seasons Patsy will see Heather through the loss of both babies and their father. She will also care for her longtime patient Nila, pregnant for the eighth time and trying to make a new life without her abusive husband. And Patsy will try to find some comfort to offer Holly, whose teenage daughter struggles with bulimia. She will help Rebba learn to find pleasure in her body and help Kaz transition into a new body.

Clare Dunkle seemed to have an ideal life - two beautiful, high-achieving teenage daughters, a loving husband, and a satisfying and successful career as a children's book novelist. But it's when you let down your guard that the ax falls. Just after one daughter successfully conquered her depression, another daughter developed a life-threatening eating disorder.

Welcome to Grace Valley, California - where blood runs thicker…ties are stronger…and love is all the more sweet. Visitors to the town often remark about the valley's peace and beauty - both of which are plentiful. Unlocked doors, front porches, pies cooling in the windows - this is country life at its finest. But visitors don't always see what lies at the heart of a community. Or just beyond.… June Hudson grew up in Grace Valley, the daughter of the town doctor. Leaving only to get her medical training, she returned home and followed in her father's footsteps.

From the moment Martha and her husband, John, conceived their second child, all hell broke loose. They were a couple obsessed with success. After years of matching IQs and test scores with less driven peers, they had two Harvard degrees apiece and were gunning for more. But the dream had begun to disintegrate. Then, when their unborn son, Adam, was diagnosed with Down syndrome, doctors, advisers, and friends in the Harvard community warned them not to keep the baby.

Emily Bell believes in destiny. To her, being forced to sing a solo in the church choir - despite her average voice - is fate: because it's while she's singing that she first sees Sam. At first sight they are connected. Sam Border wishes he could escape, but there's nowhere for him to run. He and his little brother, Riddle, have spent their entire lives constantly uprooted by their unstable father. As Sam and Riddle are welcomed into the Bells' lives, they witness the warmth and protection of a family for the first time.

In her younger years, Jillian Lauren was a college dropout, a drug addict, and an international concubine in the Prince of Brunei's harem, an experience she immortalized in her best-selling memoir, Some Girls. In her 30s, Jillian's most radical act is learning the steadying power of love when she and her rock star husband adopt an Ethiopian child with special needs.

In the idyllic small town of Tucker, Vermont, life flows at a rhythmic pace for pediatrician Paige Pfeiffer. But when Mara O'Neill, her best friend and medical partner, inexplicably kills herself, Paige's comfortable world is suddenly shattered. Temporarily caring for Mara's newly adopted baby daughter while she comes to grips with her grief, Paige clings to the hope that, in time, her orderly life will return.

What does a child's life-threatening illness cost the neighbors of Cedar Circle? What joys can be hidden in life's greatest tragedies? Behind brightly lit windows and on front porches, marriages are tested and mended, hearts broken, hopes resurrected, dreams released and reformed, values and futures shaped, and faith rekindled . . . or found for the first time.

An exuberant, one-of-a-kind novel about love and family, war and nature, new money and old values by a brilliant New Yorker contributor. The Portable Veblen is a dazzlingly original novel that's as big-hearted as it is laugh-out-loud funny. Set in and around Palo Alto amid the culture clash of new money and old (antiestablishment) values, and with the specter of our current wars looming across its words, The Portable Veblen is an unforgettable look at the way we live now.

On January 19, 2000, a fire raged through the freshman dormitory at Seton Hall University in South Orange, New Jersey, killing three students and injuring 58 others. Among the victims were Shawn Simons and Alvaro Llanos, roommates from poor neighborhoods who made their families proud by getting into college. They managed to escape the fire, but both were burned terribly.

It begins as a statistical oddity: a spike in children born with acute speech delays. Physically normal in every way, these children never speak and do not respond to speech; they don't learn to read, don't learn to write. As the number of cases grows to an epidemic level, theories spread. Maybe it's related to a popular antidepressant; maybe it's environmental. Or maybe these children have special skills all their own.

Children Playing Before a Statue of Hercules is a collection of short stories, some classic, others impending, selected and introduced by David Sedaris.

When Amy B. Scher was struck with undiagnosed late-stage, chronic Lyme disease, the best physicians in America labeled her condition incurable and potentially terminal. Deteriorating rapidly, she went on a search to save her own life - from the top experts in Los Angeles and the world-renowned Mayo Clinic in Minneapolis to a state-of-the-art hospital in Chicago. After exhausting all of her options in the US, she discovered a possible cure - but it was highly experimental, available only in India, and had as much of a probability of killing her as it did of curing her.

Dr. Rhea Lynch left a suffocating life in Charleston to practice medicine in the ER of a small South Carolina Hospital. Now, Dawkins County is her home, a place that holds the only real family she's ever known. But when she returns from vacation, Rhea is shocked to discover that her best friend, Marisa, is near death and unable to communicate. The official diagnosis: a paralyzing stroke. Despite the family's attempts to keep her away, Rhea is determined to make her own diagnosis.

Melissa had clung to the thin thread of hope given by the adoption agency that someday her newborn son might want to connect with her. When his eighteenth birthday arrived, she called the agency to simply update her contact information, not expecting a response.