Breaking Through
My Life in Science
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Narrated by:
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Eva Magyar
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By:
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Katalin Karikó
About this listen
A powerful memoir from Katalin Karikó, winner of the 2023 Nobel Prize in Physiology or Medicine, whose decades-long research led to the COVID-19 vaccines
“Katalin Karikó’s story is an inspiration.”—Bill Gates
“Riveting . . . a true story of a brilliant biochemist who never gave up or gave in.”—Bonnie Garmus, author of Lessons in Chemistry
A KIRKUS REVIEWS BEST BOOK OF THE YEAR
Katalin Karikó has had an unlikely journey. The daughter of a butcher in postwar communist Hungary, Karikó grew up in an adobe home that lacked running water, and her family grew their own vegetables. She saw the wonders of nature all around her and was determined to become a scientist. That determination eventually brought her to the United States, where she arrived as a postdoctoral fellow in 1985 with $1,200 sewn into her toddler’s teddy bear and a dream to remake medicine.
Karikó worked in obscurity, battled cockroaches in a windowless lab, and faced outright derision and even deportation threats from her bosses and colleagues. She balked as prestigious research institutions increasingly conflated science and money. Despite setbacks, she never wavered in her belief that an ephemeral and underappreciated molecule called messenger RNA could change the world. Karikó believed that someday mRNA would transform ordinary cells into tiny factories capable of producing their own medicines on demand. She sacrificed nearly everything for this dream, but the obstacles she faced only motivated her, and eventually she succeeded.
Karikó’s three-decade-long investigation into mRNA would lead to a staggering achievement: vaccines that protected millions of people from the most dire consequences of COVID-19. These vaccines are just the beginning of mRNA’s potential. Today, the medical community eagerly awaits more mRNA vaccines—for the flu, HIV, and other emerging infectious diseases.
Breaking Through isn’t just the story of an extraordinary woman. It’s an indictment of closed-minded thinking and a testament to one woman’s commitment to laboring intensely in obscurity—knowing she might never be recognized in a culture that is driven by prestige, power, and privilege—because she believed her work would save lives.
©2023 Katalin Karikó (P)2023 Random House AudioListeners also enjoyed...
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Critic reviews
“A riveting testament to resilience and the power of unwavering belief, Breaking Through charts an inspirational journey from growing up in postwar communist Hungary to transforming the world with mRNA.”—Jennifer Doudna, Nobel Prize laureate in chemistry and author of A Crack in Creation
“Katalin Karikó’s story is an inspiration. Anyone who has ever doubted that science, innovation, and persistence can change the world should read this book.”—Bill Gates, #1 New York Times bestselling author of How to Avoid a Climate Disaster
“Karikó’s proven recipe (from the creative Hungarian kitchen) for a breakthrough in science: Start with an insatiable curiosity in education and research. Then, for a few decades, look for gaps in knowledge; work hard for years to fill some of them; don’t give up because of difficulties or circumstances; and, finally, seize the opportunity to help solve one painful problem of humanity, thereby opening new horizons for the future of medicine. Bon appétit, enjoy your sweets!”—Ernő Rubik, inventor of the Rubik’s Cube and author of Cubed
“Katalin Karikó’s remarkable life story, which incidentally began not far from where I spent my childhood, inspires us not to be held back even in the face of severe difficulties. It encourages us to stay strong and follow through with important ideas that can change the world.”—Stefan Hell, Nobel Prize laureate in chemistry
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The year 1972 saw the beginning of a five-year span in which Stevie Wonder released five groundbreaking, critically acclaimed albums, garnering him more than half a dozen Grammys and more than 10 million albums sold, securing his place as one of the most important American musicians and songwriters in history. For the first time, uncover the untold story of an extraordinary artistic journey that shaped the greatest creative era in popular music history.
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Good but not great
- By Anonymous User on 09-14-24
By: Wesley Morris
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Maybe You Should Talk to Someone
- A Therapist, HER Therapist, and Our Lives Revealed
- By: Lori Gottlieb
- Narrated by: Brittany Pressley
- Length: 14 hrs and 21 mins
- Unabridged
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Overall
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Performance
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Story
One day, Lori Gottlieb is a therapist who helps patients in her Los Angeles practice. The next, a crisis causes her world to come crashing down. Enter Wendell, the quirky but seasoned therapist in whose office she suddenly lands. With his balding head, cardigan, and khakis, he seems to have come straight from Therapist Central Casting. Yet he will turn out to be anything but.
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It was like a hallmark movie being waterboarded into my ears for 15 hours
- By Amazon Customer on 10-01-19
By: Lori Gottlieb
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The Parole Room
- By: Ben Austen
- Narrated by: Ben Austen
- Length: 4 hrs and 25 mins
- Original Recording
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Overall
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Performance
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Story
Will Johnnie Veal—convicted of the murder of two police officers in 1970—be granted parole after 50 years in prison? How can he convince the parole board he’s reformed when he insists he’s innocent? What is prison time even supposed to accomplish? These are the questions that propel The Parole Room forward as it builds toward Johnnie’s 20th parole hearing—after 19 rejections.
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Enlightening story & a must read
- By Patsy on 10-07-24
By: Ben Austen
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Genghis Khan and the Making of the Modern World
- By: Jack Weatherford
- Narrated by: Jonathan Davis, Jack Weatherford
- Length: 14 hrs and 20 mins
- Unabridged
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Overall
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Performance
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Story
The Mongol army led by Genghis Khan subjugated more lands and people in 25 years than the Romans did in 400. In nearly every country the Mongols conquered, they brought an unprecedented rise in cultural communication, expanded trade, and a blossoming of civilization.
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Golden Horde/Platinum Listen
- By Cynthia on 12-11-13
By: Jack Weatherford
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Flannery O'Connor and the Scandal of Faith
- By: Jessica Hooten Wilson, The Great Courses
- Narrated by: Jessica Hooten Wilson
- Length: 3 hrs and 5 mins
- Original Recording
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Overall
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Performance
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Story
Across six revealing lectures, Professor Jessica Hooten Wilson will introduce you to one of the 20th century’s most fascinating and divisive writers in Flannery O’Connor and the Scandal of Faith. Beginning with an overview of her brief but remarkable life, Professor Wilson will then take you through an exploration of themes in O’Connor’s work and the hallmarks of her literary style. You’ll get a clearer picture of O’Connor’s historical and geographical context while digging into how her stories can transcend time and place.
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Fascinating life cut short
- By KRoss on 11-21-24
By: Jessica Hooten Wilson, and others
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Episodes
- The True Story of Two Friends & One Diagnosis
- By: Mara Altman, Kat Alexander
- Narrated by: Mara Altman, Kat Alexander
- Length: 7 hrs and 5 mins
- Original Recording
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Overall
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Performance
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Story
In Episodes, lifelong best friends Kat and Mara take listeners on an unfiltered journey through friendship, mental illness, and survival. Kat, a successful professional, is preparing for marriage and motherhood. On her fourth round of IVF, it happened—a frantic call to Mara. Mara comes over to find Kat, her friend of 25 years—the one who'd always been levelheaded, hilarious, and over-the-top thoughtful—trying to jump through a window.
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Just listen!
- By AJ on 11-17-24
By: Mara Altman, and others
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Heroes Behind Headlines
- Only the Brave
- By: Ralph Pezzullo
- Narrated by: Ralph Pezzullo
- Length: 6 hrs and 33 mins
- Original Recording
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Overall
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Performance
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Story
How did DEA agents orchestrate the capture of one of the world’s most wanted weapons dealers? How does an all-female, unarmed group of rangers stop poachers from killing South Africa’s most majestic wild animals? And how did a scrappy crew of soldiers help desperate Afghans escape Kabul during the Taliban’s rapid takeover? Welcome to Heroes Behind Headlines: Only the Brave, where host Ralph Pezzullo takes you on deep dives into extraordinary true stories, told to you by the experts and the brave men and women who lived them.
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Great interview format
- By Ronald Gauvin on 11-21-24
By: Ralph Pezzullo
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Evil Has a Name
- The Untold Story of the Golden State Killer Investigation
- By: Paul Holes, Jim Clemente, Peter McDonnell
- Narrated by: Paul Holes, Jim Clemente
- Length: 6 hrs and 13 mins
- Original Recording
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Overall
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Story
For his victims, for their families and for the investigators tasked with finding him, the senselessness and brutality of the Golden State Killer's acts were matched only by the powerlessness they felt at failing to uncover his identity. Then, on April 24, 2018, authorities arrested 72-year-old Joseph James DeAngelo at his home in Citrus Heights, Calif., based on DNA evidence linked to the crimes. Amazingly, it seemed, evil finally had a name. Please note: This work contains descriptions of violent crime and sexual assault and may not be suitable for all listeners.
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Audible Raises The Bar On True Crime Genre
- By R. Squyres on 11-16-18
By: Paul Holes, and others
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The Last Days of Cabrini-Green
- By: Ben Austen, Harrison David Rivers
- Narrated by: Ben Austen, Patina Miller, Harry Lennix, and others
- Length: 3 hrs and 32 mins
- Original Recording
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Overall
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Performance
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Story
In 1992, the deadliest year in Chicago’s history, seven-year-old Dantrell Davis was shot and killed in front of his elementary school inside the public housing complex Cabrini-Green. What happened to Dantrell led to a truce among Chicago’s gangs, but it also ignited a national panic about poverty and violence in America’s cities. Dantrell’s name would soon be used to demolish all of Chicago’s high-rise public housing, displacing tens of thousands of low-income families.
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Chicago Housibg
- By Ruby on 11-21-24
By: Ben Austen, and others
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The Demon Next Door
- By: Bryan Burrough
- Narrated by: Steve White
- Length: 2 hrs and 45 mins
- Unabridged
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Overall
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Performance
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Story
Best-selling author Bryan Burrough recently made a shocking discovery: The small town of Temple, Texas, where he had grown up, had harbored a dark secret. One of his high school classmates, Danny Corwin, was a vicious serial killer. In this chilling tale, Burrough raises important questions of whether serial killers can be recognized before they kill or rehabilitated after they do. It is also a story of Texas politics and power that led the good citizens of the town of Temple to enable a demon who was their worst nightmare.
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Odd narration choice
- By Amanda Fredericks on 03-08-19
By: Bryan Burrough
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Dear Cousin: The Stalking of Susan Fensten
- By: Ventureland
- Narrated by: Susan Fensten
- Length: 4 hrs and 24 mins
- Original Recording
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Performance
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Story
Dear Cousin: The Stalking of Susan Fensten is the gripping true story of one woman's quest for long lost family. After the deaths of her sister and estranged father, Susan searches for relatives on an early online genealogy forum. When she meets cousins from her grandfather's other family, they're everything she'd hoped for—until it all goes to hell.
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Harrowing Case, Excellent Production
- By C Lopez on 07-12-24
By: Ventureland
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The Autobiography of Malcolm X
- As Told to Alex Haley
- By: Malcolm X, Alex Haley
- Narrated by: Laurence Fishburne
- Length: 16 hrs and 52 mins
- Unabridged
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Overall
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Performance
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Story
Experience a bold take on this classic autobiography as it’s performed by Oscar-nominated Laurence Fishburne. In this searing classic autobiography, originally published in 1965, Malcolm X, the Muslim leader, firebrand, and Black empowerment activist, tells the extraordinary story of his life and the growth of the Human Rights movement. His fascinating perspective on the lies and limitations of the American dream and the inherent racism in a society that denies its non-White citizens the opportunity to dream, gives extraordinary insight into the most urgent issues of our own time.
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it's Nearly perfect
- By Kerry on 09-16-20
By: Malcolm X, and others
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Elvis and Me
- By: Priscilla Beaulieu Presley
- Narrated by: Priscilla Beaulieu Presley
- Length: 7 hrs and 30 mins
- Unabridged
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Overall
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Performance
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Story
The inspiration for the major motion picture Priscilla directed by Sofia Coppola, this New York Times best seller reveals the intimate story of Elvis Presley and Priscilla Presley, told by the woman who lived it.
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What a story!
- By Pen Name on 08-28-22
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How I Get It Done
- By: Shereen Marisol Meraji
- Narrated by: Shereen Marisol Meraji
- Length: 9 hrs and 53 mins
- Original Recording
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Overall
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Performance
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Story
In a series of deeply moving and inspiring conversations, host Shereen Marisol Meraji connects with successful women from all walks of life to reveal how they manage their careers and every aspect of their lives. Based on the long-running column from The Cut and New York Magazine.
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Relatable, helpful, and beautifully produced.
- By Anonymous User on 09-07-24
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Love in the Time of Coronavirus, Fabulous edition!
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The favorite book of William Burroughs. A journey into the hobo underworld, freight hopping around the still Wild West, becoming a highwayman and member of the yegg (criminal) brotherhood, getting hooked on opium, doing stints in jail or escaping, often with the assistance of crooked cops or judges. Our lost history revived. With an introduction by Burroughs. A BookSense 77 selection.
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Crying in the Bathroom
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Growing up as the daughter of Mexican immigrants in Chicago in the nineties, Erika Sánchez was a self-described pariah, misfit, and disappointment—a foul-mouthed, melancholic rabble-rouser who painted her nails black but also loved comedy, often laughing so hard with her friends that she had to leave her school classroom. Twenty-five years later, she’s now an award-winning novelist, poet, and essayist, but she’s still got an irrepressible laugh, an acerbic wit, and singular powers of perception about the world around her.
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I cried
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This America of Ours
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In late-1940s America, few writers commanded attention like Bernard DeVoto. Alongside his brilliant wife and editor, Avis, DeVoto was a firebrand of American liberty, free speech, and perhaps our greatest national treasure: public lands. But when a corrupt band of lawmakers, led by Senator Pat McCarran, sought to quietly cede millions of acres of national parks and other western lands to logging, mining, and private industry, the DeVotos entered the fight of their lives.
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Fascinating history of a great conservationist
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The Man from the Future
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The smartphones in our pockets and computers like brains. The vagaries of game theory and evolutionary biology. Nuclear weapons and self-replicating spacecrafts. All bear the fingerprints of one remarkable, yet largely overlooked, man: John von Neumann.
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Good book, very odd narration
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The Book of Eating
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From dim sum in Hong Kong to giant platters of Peking duck in Beijing, fresh-baked croissants in Paris and pierogi on the snowy streets of Moscow, Platt takes us around the world, re-tracing the steps of a unique, and lifelong, culinary education. Providing a glimpse into a life that has intertwined food and travel in exciting and unexpected ways, The Book of Eating is a delightful and sumptuous trip that is also the culinary coming-of-age of a voracious eater and his eventual ascension to become, as he puts it, “a professional glutton.”
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Very disappointing.
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What listeners say about Breaking Through
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- Jacob Rios
- 10-29-23
a must listen
this book is a must listen. it’s so inspirational and a lesson for how life should be lived.
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- José
- 01-10-24
Inspiring
Kaitlin's memoirs go beyond her major scientific advances to tell of her search for the unknown and her determination and resilience to find it, even without knowing that doing so would save millions of lives. One of the most inspiring stories I have read, but at the same time it reveals how there is a lot to do to support talent, especially women.
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- Linda Hart
- 11-21-23
Remarkable and inspiring story of grit and perseverance
Remarkable and inspiring story of grit and perseverance. Humanity should be forever grateful. Made me wonder how many researchers, particularly women, who quit before seeing the fruits of their labor because of poor leadership in their labs. The reader's accent created the belief that the book was delivered in the author's voice.
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- M. Colombo
- 06-02-24
Truly inspiriring
This is an amazing book. Katalin life is truly inspiring. The book it’s well written and well narrated. A Nobel price winner who had to face so many challenges.
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- Stacey
- 08-06-24
Absolutely remarkable!
This is an amazing autobiography by a skilled and determined researcher. She overcame many obstacles to achieve her discoveries and it is fortunate for humanity that she did so, considering how instrumental they were in developing a Covid vaccine. Brava!
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- Rahil Ghiasvand
- 03-24-24
Inspiring
As a newbie scientist and first Gen woman it was inspiring to hear her story.
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- Manfred Strutz
- 10-09-24
Excellent scientific information for a non scientific person!
I enjoyed both the description of the labs where she worked, the countries where she lived and the difficulties a person can encountered , specially being a woman !
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- Leo
- 09-20-24
Way better than W Isaacson’s book about J Doudna!!
Incredibly original, passionate story. It’s absolutely unbelievable that a Nobel prize winner with revolutionary research, published in 2006, would be squeezed out of her lab at the UPenn in 2013, would be told after 17 years of work there that she wasn’t a faculty material. That her breakthrough article would be outright rejected by Nature. Her patent for mRNA technology worth many billions would be sold for exclusive use for 300K by UPenn patent department etc. Unbelievable! With many billions spans on biology research, the system throws away 100 karat diamonds not once, but repeatedly!
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- Michael Divricean
- 11-04-23
The most beautiful book
This is the best book I read in years!! Thank you Katalin Kariko for never giving up
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- Cathy
- 11-26-23
The power of curiosity, tenacity and integrity in Science.
Dr. Karikó’s description of her quest for knowledge is personal, candid and perspicacious. She is intensely driven by this quest and not the science gamesmanship which is so prevalent in academic institutions.
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