It’s been a decade since Trumanell Branson disappeared, leaving only a bloody handprint behind. Her pretty face still hangs like a watchful queen on the posters on the walls of the town’s Baptist church, the police station, and in the high school. They all promise the same thing: We will find you. Meanwhile, Tru's brother, Wyatt, lives as a pariah in the desolation of the old family house, cleared of wrongdoing by the police but tried and sentenced in the court of public opinion and in a new documentary about the crime.

Patricia Campbell's life has never felt smaller. Her ambitious husband is too busy to give her a goodbye kiss in the morning, her kids have their own lives, her senile mother-in-law needs constant care, and she's always a step behind on thank-you notes and her endless list of chores. The one thing she has to look forward to is her book club, a close-knit group of Charleston women united by their love of true crime and paperback fiction. At these meetings they're as likely to talk about the Manson family as they are marriage, motherhood, and neighborhood gossip.

Hannibal Lecter emerges from the nightmare of the Eastern Front, a boy in the snow, mute, with a chain around his neck. He seems utterly alone, but he has brought his demons with him. Hannibal’s uncle, a noted painter, finds him in a Soviet orphanage and brings him to France, where Hannibal will live with his uncle and his uncle’s beautiful and exotic wife, Lady Murasaki. But Hannibal’s demons visit him and torment him. When he is old enough, he visits them in turn. He discovers he has gifts beyond the academic, and in that epiphany, Hannibal Lecter becomes death’s prodigy.

Lane McCord wakes up in a hospital having survived a near-fatal fall at a North Carolina beach cottage. Her boyfriend, Kyle, wasn’t so lucky. A senseless tragedy on their first romantic getaway. All Lane remembers is lying at the bottom of the stairs in Kyle’s pooling blood. Confused and grieving, Lane plans to return to the cottage, collect her personal belongings, and get out. Until a winter rainstorm leaves her stranded and vulnerable, but not alone. A concerned neighbor, who claims he heard a violent argument before the accident, has come out of the storm.

It's August 1984, and paperboy Christopher Stewart has gone missing. Hours later, 12-year-old Sammy Cox hurries home from his own paper route, red-faced and out of breath, hiding a terrible secret. Crystal, Sammy's 17-year-old sister, is worried by the disappearance but she also sees an opportunity: the Stewart case has echoes of an earlier unsolved disappearance of another boy, one town over. Crystal senses the makings of an award-winning essay, one that could win her a scholarship - and a ticket out of their small Iowa town.

Seventeen-year-old Molly Fisk does not go outside. She's ruled by anxiety and only feels safe in the tiny tourist-town museum she and her mother run and call home. Yearning to live free but unable to overcome deep wounds from her past, she stays hidden away. Then the chance arrival of a woman Molly knew six years ago changes everything.

Thirty-two-year-old Jess Abbot has lost everything: her job, her apartment, and - most heart-wrenching - her eight-year-old son, Chance, to a tragic accident. Haunted by memories and grief, Jess packs what’s left and heads for the small mountain town of Pine Lake, where she takes a position as caregiver to an eccentric old woman. A rumored clairvoyant, Lucy is strange but welcoming and immediately intuits Jess as a “loose end” in need of closure. But Jess isn’t the only guest in Lucy’s large Victorian home.

Emily Proudman just lost her acting agent, her job, and her apartment in one miserable day. Scott Denny, a successful and charismatic CEO, has a problem that neither his business acumen nor vast wealth can fix. Until he meets Emily. Scott offers Emily a summer job as a housekeeper on his remote, beautiful French estate. Enchanted by his lovely wife Nina, and his eccentric young daughter, Aurelia, Emily falls headlong into this oasis of wine-soaked days by the pool. But soon Emily realizes that Scott and Nina are hiding dangerous secrets.

Twenty-five years ago, the body of 16-year-old Eve Knox was found in the caves near her home in small-town Grotto, Iowa - discovered by her best friend, Maggie, and her sister, Nola. There were a handful of suspects, including her boyfriend, Nick, but without sufficient evidence the case ultimately went cold.

The Cold Creek Highway stretches close to five hundred miles through British Columbia’s rugged wilderness to the west coast. Isolated and vast, it has become a prime hunting ground for predators. For decades, young women traveling the road have gone missing. Motorists and hitchhikers, those passing through or living in one of the small towns scattered along the region, have fallen prey time and again. And no killer or abductor who has stalked the highway has ever been brought to justice.

It’s the day of his ex-wife’s wedding when Dan makes the winding mountain journey to a remote cabin for an escape from the life that another man has stepped into. Less than 48 hours into his reprieve, the forest tranquility is shattered when he looks through a telescope and witnesses the violent abduction of a young woman. Dan springs into action, but there’s no evidence of an abduction nor reports of a missing woman. That is, until Dan sees the missing person’s poster for Ivy Trent.

Rose Dennis wakes up in a hospital gown, her brain in a fog, only to discover that she's been committed to an Alzheimer's unit in a nursing home. With no memory of how she ended up in this position, Rose is sure something is very wrong. When she overhears one of the administrators saying about her that she's "not making it through the week", Rose is convinced that if she's to survive, she has to get out of the nursing home. She avoids taking her medication, putting on a show for the aides, then stages her escape. But how does she convince anyone that she's not actually demented?

Moving four times in five years has honed air force wife Ellie Avery's packing and unpacking skills. But moving with a newborn daughter and husband Mitch in tow, during a heat wave, is enough to make her turn to chocolate for comfort. And when Ellie finds a local environmentalist dead on the side of the road, her instincts tell her this was no accident.

Augusta (Gus) Monet is living an aimless existence with her grifter boyfriend when she learns that her great grandmother - her last living relative - has just died. Ditching her boyfriend, Gus returns to the home she left as a young girl. Her inheritance turns out to be a dilapidated house and an old dog named Levi. While combing through her great grandmother’s possessions, Gus stumbles across an old trunk filled with long-lost childhood belongings.

After the loss of his parents, young Jack Thatch first met Stella as a child - this cryptic little girl of eight with dark hair and darker eyes, sitting alone on a bench in the cemetery clutching her favorite book. The body of a man found in an alley, every inch of his flesh horribly burned, yet his clothing completely untouched. For Detective Faustino Brier, this wasn't the first, and he knew it wouldn't be the last. Isolated and locked away from the world in a shadowy lab, a little boy known only as Subject "D" waits, grows, learns. He's permitted to speak to no one.