Patient Zero
A Curious History of the World's Worst Diseases
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Narrated by:
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Hillary Huber
About this listen
From the masters of storytelling-meets-science and co-authors of Quackery, Patient Zero tells the long and fascinating history of disease outbreaks—how they start, how they spread, the science that lets us understand them, and how we race to destroy them before they destroy us.
Written in the authors’ lively and accessible style, chapters include gripping medical stories about a particular disease or virus—smallpox, Bubonic plague, polio, HIV—that combine “Patient Zero” narratives, or the human stories behind outbreaks, with historical examinations of missteps, milestones, scientific theories, and more.
Learn the tragic stories of Patient Zeros throughout history, such as Mabalo Lokela, who contracted Ebola while on vacation in 1976, and the Lewis Baby on London’s Broad Street, the first to catch cholera in an 1854 outbreak that led to a major medical breakthrough. Interspersed are origin stories of a different sort—how a rye fungus in 1951 turned a small village in France into a phantasmagoric scene reminiscent of Burning Man. Plus the uneasy history of human autopsy, how the HIV virus has been with us for at least a century, and more.
©2021 Lydia Kang, MD and Nate Pedersen (P)2022 Workman Publishing CompanyListeners also enjoyed...
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Critic reviews
"[A] rich and thought-provoking book... It's also a profound reconsideration of our common understanding of our most famous stories of sickness and science." —Salon.com
“A thorough and morbidly funny study of some of the world’s deadliest diseases… Readers will be swept away by this energetic and enlightening survey.” —Publishers Weekly, starred review
“A fascinating foray into the etiology of fevers, flus, and other foul febrilities.” —James Nestor, New York Times bestselling author of Breath: The New Science of a Lost Art
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- The Hundred-Year Hunt to Cure the 1918 Spanish Flu Pandemic
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- Narrated by: Holter Graham
- Length: 6 hrs and 28 mins
- Unabridged
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On the 100th anniversary of the devastating pandemic of 1918, Jeremy Brown, a veteran ER doctor, explores the troubling, terrifying, and complex history of the flu virus, from the origins of the Great Flu that killed millions, to vexing questions such as: are we prepared for the next epidemic, should you get a flu shot, and how close are we to finding a cure?
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Important read
- By Kathryn C. on 12-21-18
By: Dr. Jeremy Brown
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The Moth in the Iron Lung
- A Biography of Polio
- By: Forrest Maready
- Narrated by: Forrest Maready
- Length: 5 hrs and 54 mins
- Unabridged
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A fascinating account of the world’s most famous disease - polio - told as you have never heard it before. Epidemics of paralysis began to rage in the early 1900s, seemingly out of nowhere. Doctors, parents, and health officials were at a loss to explain why this formerly unheard-of disease began paralyzing so many children. Why did this disease start to become such a horrible problem during the late 1800s? Why did it affect children more often than adults? Why was it originally called teething paralysis by mothers and their doctors?
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Root Cause
- By Circlekay1 Gulfport MS on 10-24-19
By: Forrest Maready
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Pandemic
- Tracking Contagions, from Cholera to Ebola and Beyond
- By: Sonia Shah
- Narrated by: Sonia Shah
- Length: 9 hrs and 34 mins
- Unabridged
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Interweaving history, original reportage, and personal narrative, Pandemic explores the origin of epidemics, drawing parallels between the story of cholera - one of history's most disruptive and deadly pathogens - and the new pathogens that stalk humankind today, from Ebola and avian influenza to drug-resistant superbugs.
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You will probably enjoy "Spillover" more
- By serine on 03-01-16
By: Sonia Shah
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Chronic
- The Hidden Cause of the Autoimmune Pandemic and How to Get Healthy Again
- By: Steven Phillips MD, Dana Parish, Kristin Loberg
- Narrated by: Teri Schnaubelt, Thomas Allen
- Length: 10 hrs and 42 mins
- Unabridged
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In this timely book, Steven Phillips, MD, and his former patient, Sony singer-songwriter Dana Parish, reveal striking evidence that a broad range of common infections, from COVID-19 to Lyme and many others, cause a variety of autoimmune, psychiatric, and chronic conditions. Chronic explores the science behind what makes them difficult to diagnose and treat, debunks widely held beliefs by doctors and patients alike, and provides solutions that empower sufferers to reclaim their lives.
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A must read book
- By Amazon Customer on 03-01-21
By: Steven Phillips MD, and others
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An Epidemic of Absence
- A New Way of Understanding Allergies and Autoimmune Diseases
- By: Moises Velasquez-Manoff
- Narrated by: Chris Sorensen
- Length: 17 hrs and 6 mins
- Unabridged
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An Epidemic of Absence asks what will happen in developing countries, which, as they become more affluent, have already seen an uptick in allergic disease: Will India end up more allergic than Europe? Velasquez-Manoff also details a controversial underground movement that has coalesced around the treatment of immune-mediated disorders with parasites. Against much of his better judgment, he joins these do-it-yourselfers and reports his surprising results.
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The point of view from a Veterinarian immunologist
- By rtgymnast on 11-03-17
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Happy Accidents
- Serendipity in Major Medical Breakthroughs in the Twentieth Century
- By: Morton A. Meyers
- Narrated by: Richard Waterhouse
- Length: 12 hrs and 37 mins
- Unabridged
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Happy Accidents is a fascinating, entertaining, and highly accessible look at the surprising role serendipity has played in some of the most important medical discoveries in the 20th century. What do penicillin, chemotherapy drugs, X-rays, Valium, the Pap smear, and Viagra have in common? They were each discovered accidentally, stumbled upon in the search for something else. In discussing medical breakthroughs, Dr. Morton Meyers makes a cogent, highly engaging argument for a more creative, rather than purely linear, approach to science. And it may just save our lives!
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Don't waste your money!
- By Amazon Customer on 03-20-16
By: Morton A. Meyers
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COVID: The Politics of Fear and the Power of Science
- By: Marc Siegel MD
- Narrated by: Peter Van Norden
- Length: 9 hrs and 19 mins
- Unabridged
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COVID-19 has stolen our security and our nation's peace of mind. There is a pandemic virus as well as a crippling epidemic of fear sweeping America. Why? The answer, according to nationally renowned health commentator Dr. Marc Siegel, is that we already lived in an artificially created culture of fear that was just waiting to be unleashed. In COVID: The Politics of Fear and the Power of Science, Siegel identifies three major catalysts of the culture of fear - government, the media, and our own psyche.
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Informative and well sourced
- By A. Powers on 10-12-21
By: Marc Siegel MD
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10% Human
- How Your Body's Microbes Hold the Key to Health and Happiness
- By: Alanna Collen
- Narrated by: Cat Gould
- Length: 12 hrs and 45 mins
- Unabridged
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You are just 10% human. For every one of the cells that make up the vessel that you call your body, there are nine impostor cells hitching a ride. You are not just flesh and blood, muscle and bone, brain and skin, but also bacteria and fungi. Over your lifetime, you will carry the equivalent weight of five African elephants in microbes. You are not an individual but a colony. Until recently, we had thought our microbes hardly mattered, but science is revealing a different story, one in which microbes run our bodies and becoming a healthy human is impossible without them.
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Must read for anyone that wants to be healthy
- By T. Kalinowski on 06-05-21
By: Alanna Collen
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Pale Rider
- The Spanish Flu of 1918 and How It Changed the World
- By: Laura Spinney
- Narrated by: Paul Hodgson
- Length: 10 hrs and 4 mins
- Unabridged
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In this gripping narrative history, Laura Spinney traces the overlooked pandemic to reveal how the virus travelled across the globe, exposing mankind's vulnerability and putting our ingenuity to the test. As socially significant as both world wars, the Spanish flu dramatically disrupted - and often permanently altered - global politics, race relations, and family structures while spurring innovation in medicine, religion, and the arts.
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A Predilection for Those in the Prime of Life
- By Cynthia on 02-12-18
By: Laura Spinney
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Seven Modern Plagues
- And How We Are Causing Them
- By: Mark Jerome Walter
- Narrated by: Brian Troxell
- Length: 5 hrs and 11 mins
- Unabridged
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According to veterinarian and journalist Mark Walters, we are contributing to - if not overtly causing - some of the scariest epidemics of our time. Through human stories and cutting-edge science, Walters explores the origins of seven diseases: Mad Cow Disease, HIV/AIDS, Salmonella DT104, Lyme Disease, Hantavirus, West Nile, and new strains of flu. He shows that they originate from manipulation of the environment, from emitting carbon and clear-cutting forests to feeding naturally herbivorous cows “recycled animal protein.”
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Frightening, truthful and a real eye opener
- By RobJD on 02-23-15
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The Family That Couldn't Sleep
- A Medical Mystery
- By: D.T. Max
- Narrated by: Grover Gardner
- Length: 8 hrs and 45 mins
- Unabridged
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For 200 years, a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. What these strange conditions share is their cause: prions.
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A great scientific mystery
- By David on 11-04-06
By: D.T. Max
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The Great Influenza
- The Epic Story of the Deadliest Plague in History
- By: John M. Barry
- Narrated by: Scott Brick
- Length: 19 hrs and 26 mins
- Unabridged
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In the winter of 1918, at the height of World War I, history's most lethal influenza virus erupted in an army camp in Kansas, moved east with American troops, then exploded, killing as many as 100 million people worldwide. It killed more people in 24 weeks than AIDS has killed in 24 years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision between modern science and epidemic disease.
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Great book but very disturbing...
- By Tim on 01-15-09
By: John M. Barry
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The Fever
- Malaria Has Ruled Humankind for 500,000 Years
- By: Sonia Shah
- Narrated by: Maha Chehlaoui
- Length: 8 hrs and 37 mins
- Unabridged
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In recent years, malaria has emerged as a cause célèbre for voguish philanthropists. Bill Gates, Bono, and Laura Bush are only a few of the personalities who have lent their names - and opened their pocketbooks - in hopes of curing the disease. Still, in a time when every emergent disease inspires waves of panic, why aren’t we doing more to eradicate one of our oldest foes? And how does a parasitic disease that we’ve known how to prevent for more than a century still infect 500 million people every year, killing nearly 1 million of them?
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Solid but not amazing account of malaria
- By S. Yates on 04-11-16
By: Sonia Shah
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A puzzling series of dental explosions beginning in the 19th century is just one of many strange tales that have long lain undiscovered in the pages of old medical journals. Award-winning medical historian Thomas Morris delivers one of the most remarkable, cringe-inducing collections of stories ever assembled.
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It can come in waves - like tidal waves. It changes societies. It disrupts life. It ends lives. As far back as 3000 B.C.E. (the Bronze Age), plagues have stricken mankind. COVID-19 is just the latest example, but history shows that life continues. It shows that knowledge and social cooperation can save lives. Viruses are neither alive nor dead and are the closest thing we have to zombies. Their only known function is to replicate themselves, which can have devastating consequences on their hosts.
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Imagine undergoing an operation without anesthesia performed by a surgeon who refuses to sterilize his tools - or even wash his hands. This was the world of medicine when Thomas Dent Mütter began his trailblazing career as a plastic surgeon in Philadelphia during the middle of the 19th century. Although he died at just 48, Mütter was an audacious medical innovator who pioneered the use of ether as anesthesia, the sterilization of surgical tools, and a compassion-based vision for helping the severely deformed, which clashed spectacularly with the sentiments of his time.
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Most Delicious Poison
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Scratch beneath the surface of a coffee bean, a red pepper flake, a poppy seed, a mold spore, a foxglove leaf, a magic-mushroom cap, a marijuana bud, or an apple seed, and we find a bevy of strange chemicals. We use these to greet our days (caffeine), titillate our tongues (capsaicin), recover from surgery (opioids), cure infections (penicillin), mend our hearts (digoxin), bend our minds (psilocybin), calm our nerves (CBD), and even kill our enemies (cyanide). But why do plants and fungi produce such chemicals? And how did we come to use and abuse some of them?
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Off topic
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Get Well Soon
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In 1518, in a small town in Alsace, Frau Troffea began dancing and didn't stop. She danced until she was carried away six days later, and soon 34 more villagers joined her. Then more. In a month more than 400 people had been stricken by the mysterious dancing plague. In late-19th-century England an eccentric gentleman founded the No Nose Club in his gracious townhome - a social club for those who had lost their noses, and other body parts, to the plague of syphilis for which there was then no cure.
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Didn't know syphilis could be so fascinating.
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Strange Medicine
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Now published in five languages, Strange Medicine casts a gimlet eye on the practice of medicine through the ages that highlights the most dubious ideas, bizarre treatments, and biggest blunders. From bad science and oafish behavior to stomach-turning procedures that hurt more than helped, Strange Medicine presents strange but true facts and an honor roll of doctors, scientists, and dreamers who inadvertently turned the clock of medicine backward.
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A Beautiful Poison
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Just beyond the Gilded Age, in the mist-covered streets of New York, the deadly Spanish influenza ripples through the city. But with so many victims in her close circle, young socialite Allene questions if the flu is really to blame. All appear to have been poisoned - and every death was accompanied by a mysterious note.
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It had potential, but faltered in execution
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Ingredients
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Cheese puffs. Coffee. Sunscreen. Vapes. George Zaidan reveals what will kill you, what won’t, and why - explained with high-octane hilarity, hysterical hijinks, and other things that don’t begin with the letter H. Ingredients offers the perspective of a chemist on the stuff we eat, drink, inhale, and smear on ourselves. Apart from the burning question of whether you should eat that Cheeto, Zaidan explores a range of topics.
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Disappointed in the nutrition conclusion
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Viruses, Plagues, and History
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The story of viruses and humanity is a story of fear and ignorance, of grief and heartbreak, and of great bravery and sacrifice. Michael Oldstone tells all these stories as he illuminates the history of the devastating diseases that have tormented humanity, focusing mostly on the most famous viruses. For this revised edition, Oldstone includes discussions of new viruses like SARS, bird flu, virally caused cancers, chronic wasting disease, and West Nile. Viruses, Plagues, and History paints a sweeping portrait of humanity's long-standing conflict with our unseen viral enemies.
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very detailed, but very statistical
- By ekhensel15 on 01-12-19
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Plagues and Peoples
- By: William H. McNeill
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- Unabridged
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Upon its original publication, Plagues and Peoples was an immediate critical and popular success, offering a radically new interpretation of world history. With the identification of AIDS in the early 1980s, another chapter was added to this chronicle of events, which William McNeill explores in his introduction to this edition. McNeill’s highly acclaimed work is a brilliant and challenging account of the effects of disease on human history. His sophisticated analysis and detailed grasp of the subject make this book fascinating to listen to.
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Great book!
- By Moviebuff82 on 07-18-24
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The Royal Art of Poison
- Filthy Palaces, Fatal Cosmetics, Deadly Medicine, and Murder Most Foul
- By: Eleanor Herman
- Narrated by: Susie Berneis
- Length: 10 hrs and 31 mins
- Unabridged
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The story of poison is the story of power. For centuries, royal families have feared the gut-roiling, vomit-inducing agony of a little something added to their food or wine by an enemy. To avoid poison, they depended on tasters, unicorn horns, and antidotes tested on condemned prisoners. Servants licked the royal family's spoons, tried on their underpants, and tested their chamber pots. Ironically, royals terrified of poison were unknowingly poisoning themselves daily with their cosmetics, medications, and filthy living conditions.
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Relieved and surprised
- By Amber on 09-28-18
By: Eleanor Herman
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Pseudoscience
- An Amusing History of Crackpot Ideas and Why We Love Them
- By: Lydia Kang MD, Nate Pedersen
- Narrated by: Hillary Huber
- Length: 9 hrs
- Unabridged
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The Bermuda Triangle. Personality tests. Ghost hunting. Crop circles. Mayan Doomsday. What do all these have in common? None can quite live up the rigor of actual facts or science and yet they all attract passionate supporters anyway. Divided into broad sections covering the easily disproved to the wildly speculative to wishful thinking and of course hucksterism, Pseudoscience is a romp through much more than bad science—it’s a light-hearted look into why we insist on believing in things such as Big Foot, astrology, and the existence of aliens.
By: Lydia Kang MD, and others
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The Masters of Medicine
- Our Greatest Triumphs in the Race to Cure Humanity's Deadliest Diseases
- By: Andrew Lam
- Narrated by: Jason Vu
- Length: 10 hrs and 42 mins
- Unabridged
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Human history hinges on the battle to confront our most dangerous enemies—the half-dozen diseases responsible for killing almost all of mankind. The story of our medical triumphs reveals an inspiring tapestry of human achievement, but the journey was far from smooth. It is a tale replete with dramatic episodes as spellbinding as any blockbuster Hollywood movie. In The Masters of Medicine, Dr. Andrew Lam, an award-winning author and retinal surgeon, distills the long arc of medical progress down to the crucial moments that were responsible for the world's greatest medical miracles.
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Medical history comes to life
- By Clayton on 11-04-23
By: Andrew Lam
What listeners say about Patient Zero
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- aaron
- 01-23-22
Excellent Pop Science Book
For what it is, another popular science book on another very timely and VERY interesting subject, the book nails the mark. The narrator is excellent and the stories/histories of each of the relevant outbreaks is intriguing. Great book.
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- rafojas
- 05-05-24
Great book, lots of new information.
I love this sort of medical/science/investigative/plague stuff. So I’m very familiar with a lot of the information in any one of these books I pick up. But there was lots of good information in here some of which I already knew but came from a new angle some of which I hadn’t heard before. I can say if you enjoy this and you haven’t read spillover yet you should add that one to your list.
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- Margaret Sells
- 12-15-21
Great info
Great info inside a great story. Will give this audio book as a gift to my son who thinks he knows it all.
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- Anonymous User
- 07-14-22
Timely, informative, entertaining but not overwhelming
As my province enters it’s 7th wave of COVID and I currently know more people dealing with active infections than ever before, I _really_ appreciated that this was not a chronological description of disease outbreaks.
Lots of information on areas where I only had surface levels of knowledge. I enjoyed it a lot.
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- Amanda
- 02-01-24
utterly fascinating!
what a fantastic book! I learned so much and was horrified by so much (couldn't listen to the covid chapter because it made me upset. as well as the native Americans being decimated by the various awful diseases white people brought over) but beside that. I couldn't get enough. I hope to find more books by these authors.
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- Marsha L. Woerner
- 08-19-24
more information than the US media gives
(As posted in Goodreads)
The title of this book is not nearly as telling as the subtitle; patient zero per se does not talk about the diseases or their methods of contagion or whatever. I'm sure that this is not the topic for many readers, but it was very interesting and informative! I already knew a whole lot of this come on but some of the details were captivating. And I really liked being reminded!
For instance, Ebola, the disease, is terrifying, but the national media really addressed more the parts that make one scared than the true situation. The end of the book got more into history and what we have discovered about disease, viruses, bacteria, pathogens in general, and the science around all of it. Some of the background and well known diseases- such as rabies- was interesting and enlightening.
Well, this review has been somewhat rambling, but I think I stuck all the pertinent points. If you're interested in medicine and the history, read the book; you'll like it.
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- Tana
- 06-13-22
Timely and Historic
Should be required reading for all whiners of our current time. You might learn something.
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- Heaven Kelbaugh
- 10-01-24
Great book but biased
Book was very informative and a great book on the history of diseases but I lost interest with their political views. Very biased and not needed.
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- Holly J.
- 10-03-24
Little known facts about diseases that EVERYONE should know!
Throughly enjoyed this book! I'm an Infection Preventionist and I learned so much, but in a way that was entertaining. This book should be in everyone's library.
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- Nom d'guerra
- 10-11-24
Politics, not science
This book is purely partisan politics. If you want to know why the medical industrial complex has completely lost all trust, this book will show you the answer. Even the narrator sounded smug.
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