Gifty is a sixth-year PhD candidate in neuroscience at the Stanford University School of Medicine studying reward-seeking behavior in mice and the neural circuits of depression and addiction. Her brother, Nana, was a gifted high school athlete who died of a heroin overdose after an ankle injury left him hooked on OxyContin. Her suicidal mother is living in her bed. Gifty is determined to discover the scientific basis for the suffering she sees all around her.

On the day the government decrees that women are no longer allowed more than 100 words daily, Dr. Jean McClellan is in denial. This can't happen here. Not in America. Not to her. This is just the beginning. Soon women are not permitted to hold jobs. Girls are no longer taught to read or write. Females no longer have a voice. Before, the average person spoke 16,000 words a day, but now women only have 100 to make themselves heard. But this is not the end. For herself, her daughter, and every woman silenced, Jean will reclaim her voice.

Meet the Cooke family: Mother and Dad, brother Lowell, sister Fern, and Rosemary, who begins her story in the middle. She has her reasons. “I was raised with a chimpanzee”, she explains. “I tell you Fern was a chimp and already you aren’t thinking of her as my sister. But until Fern’s expulsion...she was my twin, my funhouse mirror, my whirlwind other half and I loved her as a sister”. As a child, Rosemary never stopped talking. Then, something happened, and Rosemary wrapped herself in silence.

The world as we know it is ending. Evolution has reversed itself, affecting every living creature on earth. Science cannot stop the world from running backward, as woman after woman gives birth to infants that appear to be primitive species of humans. Thirty-two-year-old Cedar Hawk Songmaker, adopted daughter of a pair of big-hearted, open-minded Minneapolis liberals, is as disturbed and uncertain as the rest of America around her. But for Cedar, this change is profound and deeply personal. She is four months pregnant.

In The Power, the world is a recognizable place: There's a rich Nigerian boy who lounges around the family pool; a foster kid whose religious parents hide their true nature; an ambitious American politician; a tough London girl from a tricky family. But then a vital new force takes root and flourishes, causing their lives to converge with devastating effect. Teenage girls now have immense physical power: They can cause agonizing pain and even death. And, with this small twist of nature, the world drastically resets.

God is change. That is the central truth of the Earthseed movement, whose unlikely prophet is 18-year-old Lauren Olamina. The young woman's diary entries tell the story of her life amid a violent 21st-century hell of walled neighborhoods and drug-crazed pyromaniacs - and reveal her evolving Earthseed philosophy. Against a backdrop of horror emerges a message of hope: if we are willing to embrace divine change, we will survive to fulfill our destiny among the stars.

Hannah Payne awakens to a nightmare. She is lying on a table in a bare room, covered only by a paper gown, with cameras broadcasting her every move to millions at home. She is now a convicted criminal, and her skin color has been genetically altered. Her crime, according to the State of Texas: the murder of her unborn child, whose father she refuses to name. Her color: red. The color of newly shed blood.

After a staged terrorist attack kills the President and most of Congress, the government is deposed and taken over by the oppressive and all-controlling Republic of Gilead. Offred is a Handmaid serving in the household of the enigmatic Commander and his bitter wife. She can remember a time when she lived with her husband and daughter and had a job, before she lost even her own name.

The year is 2025, and a mysterious virus has broken out in Scotland - a lethal illness that seems to effect only men. When Dr. Amanda MacLean reports this phenomenon, she is dismissed as hysterical. By the time her warning is heeded, it is too late. The virus becomes a global pandemic - and a political one. The victims are all men. The world becomes alien - a women's world.

In Garner County, girls are told they have the power to lure grown men from their beds, to drive women mad with jealousy. That’s why they’re banished for their 16th year, to release their magic into the wild so they can return purified and ready for marriage. But not all of them will make it home alive. Sixteen-year-old Tierney James dreams of a better life - a society that doesn’t pit friend against friend or woman against woman, but as her own grace year draws near, she quickly realizes that it’s not just the brutal elements they must fear.

It is the last season of high school life for Nadia Turner, a rebellious, grief-stricken, 17-year-old beauty. Mourning her own mother's recent suicide, she takes up with the local pastor's son. Luke Sheppard is 21, a former football star whose injury has reduced him to waiting tables at a diner. They are young; it's not serious. But the pregnancy that results from this teen romance—and the subsequent cover-up—will have an impact that goes far beyond their youth.

For almost a decade, Claudia has counseled patients at Mercy Street, a clinic in the heart of the city. The work is consuming, the unending dramas of women in crisis. For its patients, Mercy Street offers more than health care; for many, it is a second chance. But outside the clinic, the reality is different. Anonymous threats are frequent. A small, determined group of anti-abortion demonstrators appears each morning at its door.

Olivia McAfee knows what it feels like to start over. Her picture-perfect life—living in Boston, married to a brilliant cardiothoracic surgeon, raising their beautiful son, Asher—was upended when her husband revealed a darker side. She never imagined that she would end up back in her sleepy New Hampshire hometown, living in the house she grew up in and taking over her father’s beekeeping business. Lily Campanello is familiar with do-overs, too. When she and her mom relocate to Adams, New Hampshire, for her final year of high school, they both hope it will be a fresh start.

This is the way the world ends...for the last time. It starts with the great red rift across the heart of the world's sole continent, spewing ash that blots out the sun. It starts with death, with a murdered son and a missing daughter. It starts with betrayal, and long dormant wounds rising up to fester. This is the Stillness, a land long familiar with catastrophe, where the power of the Earth is wielded as a weapon. And where there is no mercy.

The Vignes twin sisters will always be identical. But after growing up together in a small, Southern Black community and running away at age 16, it's not just the shape of their daily lives that is different as adults, it's everything: Their families, their communities, their racial identities. Many years later, one sister lives with her Black daughter in the same Southern town she once tried to escape. The other secretly passes for White, and her White husband knows nothing of her past.