Gifty is a sixth-year PhD candidate in neuroscience at the Stanford University School of Medicine studying reward-seeking behavior in mice and the neural circuits of depression and addiction. Her brother, Nana, was a gifted high school athlete who died of a heroin overdose after an ankle injury left him hooked on OxyContin. Her suicidal mother is living in her bed. Gifty is determined to discover the scientific basis for the suffering she sees all around her.

On the day the government decrees that women are no longer allowed more than 100 words daily, Dr. Jean McClellan is in denial. This can't happen here. Not in America. Not to her. This is just the beginning. Soon women are not permitted to hold jobs. Girls are no longer taught to read or write. Females no longer have a voice. Before, the average person spoke 16,000 words a day, but now women only have 100 to make themselves heard. But this is not the end. For herself, her daughter, and every woman silenced, Jean will reclaim her voice.

Meet the Cooke family: Mother and Dad, brother Lowell, sister Fern, and Rosemary, who begins her story in the middle. She has her reasons. “I was raised with a chimpanzee”, she explains. “I tell you Fern was a chimp and already you aren’t thinking of her as my sister. But until Fern’s expulsion...she was my twin, my funhouse mirror, my whirlwind other half and I loved her as a sister”. As a child, Rosemary never stopped talking. Then, something happened, and Rosemary wrapped herself in silence.

The world as we know it is ending. Evolution has reversed itself, affecting every living creature on earth. Science cannot stop the world from running backward, as woman after woman gives birth to infants that appear to be primitive species of humans. Thirty-two-year-old Cedar Hawk Songmaker, adopted daughter of a pair of big-hearted, open-minded Minneapolis liberals, is as disturbed and uncertain as the rest of America around her. But for Cedar, this change is profound and deeply personal. She is four months pregnant.

In The Power, the world is a recognizable place: There's a rich Nigerian boy who lounges around the family pool; a foster kid whose religious parents hide their true nature; an ambitious American politician; a tough London girl from a tricky family. But then a vital new force takes root and flourishes, causing their lives to converge with devastating effect. Teenage girls now have immense physical power: They can cause agonizing pain and even death. And, with this small twist of nature, the world drastically resets.

God is change. That is the central truth of the Earthseed movement, whose unlikely prophet is 18-year-old Lauren Olamina. The young woman's diary entries tell the story of her life amid a violent 21st-century hell of walled neighborhoods and drug-crazed pyromaniacs - and reveal her evolving Earthseed philosophy. Against a backdrop of horror emerges a message of hope: if we are willing to embrace divine change, we will survive to fulfill our destiny among the stars.

Hannah Payne awakens to a nightmare. She is lying on a table in a bare room, covered only by a paper gown, with cameras broadcasting her every move to millions at home. She is now a convicted criminal, and her skin color has been genetically altered. Her crime, according to the State of Texas: the murder of her unborn child, whose father she refuses to name. Her color: red. The color of newly shed blood.

After a staged terrorist attack kills the President and most of Congress, the government is deposed and taken over by the oppressive and all-controlling Republic of Gilead. Offred is a Handmaid serving in the household of the enigmatic Commander and his bitter wife. She can remember a time when she lived with her husband and daughter and had a job, before she lost even her own name.

The year is 2025, and a mysterious virus has broken out in Scotland - a lethal illness that seems to effect only men. When Dr. Amanda MacLean reports this phenomenon, she is dismissed as hysterical. By the time her warning is heeded, it is too late. The virus becomes a global pandemic - and a political one. The victims are all men. The world becomes alien - a women's world.

In Garner County, girls are told they have the power to lure grown men from their beds, to drive women mad with jealousy. That’s why they’re banished for their 16th year, to release their magic into the wild so they can return purified and ready for marriage. But not all of them will make it home alive. Sixteen-year-old Tierney James dreams of a better life - a society that doesn’t pit friend against friend or woman against woman, but as her own grace year draws near, she quickly realizes that it’s not just the brutal elements they must fear.

It is the last season of high school life for Nadia Turner, a rebellious, grief-stricken, 17-year-old beauty. Mourning her own mother's recent suicide, she takes up with the local pastor's son. Luke Sheppard is 21, a former football star whose injury has reduced him to waiting tables at a diner. They are young; it's not serious. But the pregnancy that results from this teen romance—and the subsequent cover-up—will have an impact that goes far beyond their youth.

For almost a decade, Claudia has counseled patients at Mercy Street, a clinic in the heart of the city. The work is consuming, the unending dramas of women in crisis. For its patients, Mercy Street offers more than health care; for many, it is a second chance. But outside the clinic, the reality is different. Anonymous threats are frequent. A small, determined group of anti-abortion demonstrators appears each morning at its door.

Olivia McAfee knows what it feels like to start over. Her picture-perfect life—living in Boston, married to a brilliant cardiothoracic surgeon, raising their beautiful son, Asher—was upended when her husband revealed a darker side. She never imagined that she would end up back in her sleepy New Hampshire hometown, living in the house she grew up in and taking over her father’s beekeeping business. Lily Campanello is familiar with do-overs, too. When she and her mom relocate to Adams, New Hampshire, for her final year of high school, they both hope it will be a fresh start.

The Vignes twin sisters will always be identical. But after growing up together in a small, Southern Black community and running away at age 16, it's not just the shape of their daily lives that is different as adults, it's everything: Their families, their communities, their racial identities. Many years later, one sister lives with her Black daughter in the same Southern town she once tried to escape. The other secretly passes for White, and her White husband knows nothing of her past.

Edie is stumbling her way through her 20s - sharing a subpar apartment in Bushwick, clocking in and out of her admin job, making a series of inappropriate sexual choices. She is also haltingly, fitfully giving heat and air to the art that simmers inside her. And then she meets Eric, a digital archivist with a family in New Jersey, including an autopsist wife who has agreed to an open marriage - with rules.

Lit follows Mary Karr's descent into the inferno of alcoholism and madness - and her astonishing resurrection. Karr's longing for a solid family seems secure when her marriage to a handsome, Shakespeare-quoting poet produces a son they adore. But she can't outrun her apocalyptic past. She drinks herself into the same numbness that nearly devoured her charismatic but troubled mother, reaching the brink of suicide. A hair-raising stint in "The Mental Marriott" awakens her to the possibility of joy, and leads her to an unlikely faith.

Meet Dolores Price. She's 13, wise-mouthed but wounded, having bid her childhood goodbye. Beached like a whale in front of her bedroom TV, she spends the next few years nourishing herself with the Mallomars, potato chips, and Pepsi her anxious mother supplies. When she finally rolls into young womanhood at 257 pounds, Dolores is no stronger and life is no kinder. But this time she's determined to rise to the occasion and give herself one more chance before really going belly-up.

There's something eerily unsettling about Ottessa Moshfegh's stories, something almost dangerous, while also being delightful and even laugh-out-loud funny. Her characters are all unsteady on their feet in one way or another; they all yearn for connection and betterment, though each in very different ways, but they are often tripped up by their own baser impulses and existential insecurities.

For years Chuck Palahniuk has reserved his best storytelling for his readings, often choosing to read a new short story instead of whatever novel he is supposed to be promoting. Make Something Up compiles these previously unpublished tales for the very first time, plus the Byliner social media insta-classic "Phoenix" and Palahniuk's most notable pieces from Playboy.

Everything about 15-year-old Cat's new town in rural Michigan is lonely and off-kilter until she meets her neighbor, the manic, beautiful, pill-popping Marlena. Cat, inexperienced and desperate for connection, is quickly lured into Marlena's orbit by little more than an arched eyebrow and a shake of white-blond hair. As the two girls turn the untamed landscape of their desolate small town into a kind of playground, Cat catalogues a litany of firsts - first drink, first cigarette, first kiss - while Marlena's habits harden and calcify.

Maddy is a social worker trying to balance her career and three children. Years ago, she fell in love with Ben, a public defender, drawn to his fiery passion, but now he's lashing out at her during his periodic verbal furies. She vacillates between tiptoeing around him and asserting herself for the sake of their kids - which works to keep a fragile peace - until the rainy day when they're together in the car and Ben's volatile temper gets the best of him, leaving Maddy in the hospital fighting for her life.

Children Playing Before a Statue of Hercules is a collection of short stories, some classic, others impending, selected and introduced by David Sedaris.

At age 39, Ariel Gore has everything she’s always wanted: a successful writing career, a long-term partnership, a beautiful if tiny home, a daughter in college and a son in preschool. But life’s happy endings don’t always last. If it’s not one thing, after all, it’s your mother. Her name is Eve. Her epic temper tantrums have already gotten her banned from three cab companies in Portland. And she’s here to announce that she’s dying.

Few authors write with such sheer love of story and language as T. C. Boyle, and that is nowhere more evident than in his inventive, wickedly funny, and always entertaining short stories. Here are 14 new tales previously unpublished in book form. By turns mythic and realistic, farcical and tragic, ironic and moving, Boyle's stories have mapped a wide range of human emotions. The stories here reflect his maturing themes.

The best stories pull readers in and keep them turning the pages, eager to discover more—to find the answer to the question: "And then what happened?" The true hallmark of great literature is great imagination, and as Neil Gaiman and Al Sarrantonio prove with this outstanding collection, when it comes to great fiction, all genres are equal.

A young woman sits in jail, accused of the mercy killing of her dying mother. She didn't do it, but she thinks she knows who did. In the last months of her life, Ellen Gulden's mother revealed startling secrets that challenged everything Ellen believed about her family. Now, in jail, Ellen believes those secrets will tell her who had the courage to end her mother's suffering.

This powerful and haunting memoir details the years Paula McLain and her two sisters spent as foster children after being abandoned by both parents in California in the early 1970s. As wards of the State, the sisters spent the next 14 years moving from foster home to foster home. The dislocations, confusions, and odd pleasures of an unrooted life form the basis of one of the most compelling memoirs in recent years - a book in the tradition of Jo Ann Beard's The Boys of My Youth and Mary Karr's The Liars' Club.

Margo is not like other girls. She lives in a derelict neighborhood called the Bone, in a cursed house, with her cursed mother, who hasn't spoken to her in over two years. She lives her days feeling invisible. It's not until she develops a friendship with her wheelchair-bound neighbor, Judah Grant, that things begin to change. When a neighborhood girl, seven-year-old Neveah Anthony, goes missing, Judah sets out to help Margo uncover what happened to her. What Margo finds changes her, and with a new perspective on life she's determined to find evil and punish it.

The unsolved murder of a farm family haunts the small, white, off-reservation town of Pluto, North Dakota. The vengeance exacted for this crime and the subsequent distortions of truth transform the lives of Ojibwe living on the nearby reservation and shape the passions of both communities for the next generation.

Joy Williams has been celebrated as a master of the short story for four decades, her renown passing from one generation to the next even in the shifting landscape of contemporary writing. And at long last the incredible scope of her singular achievement is put on display: 33 stories drawn from three much-lauded collections and another 13 appearing here for the first time in book form.

Hannah Payne awakens to a nightmare. She is lying on a table in a bare room, covered only by a paper gown, with cameras broadcasting her every move to millions at home. She is now a convicted criminal, and her skin color has been genetically altered. Her crime, according to the State of Texas: the murder of her unborn child, whose father she refuses to name. Her color: red. The color of newly shed blood.

Bea’s five-year-old daughter, Agnes, is slowly wasting away, consumed by the smog and pollution of the overdeveloped metropolis that most of the population now calls home. If they stay in the city, Agnes will die. There is only one alternative: the Wilderness State, the last swath of untouched, protected land, where people have always been forbidden. Until now.

King has tenderly staked out a territory for his wife and three daughters, Grace, Lia, and Sky. He has lain the barbed wire; he has anchored the buoys in the water; he has marked out a clear message: Do not enter. Or viewed from another angle: Not safe to leave. Here women are protected from the chaos and violence of men on the mainland. The cult-like rituals and therapies they endure fortify them from the spreading toxicity of a degrading world. But when their father, the only man they've ever seen, disappears, they retreat further inward until the day two men and a boy wash ashore.

Years ago, just before the country was incinerated to wasteland, 10 men and their families colonized an island off the coast. They built a radical society of ancestor worship, controlled breeding, and the strict rationing of knowledge and history. Only the Wanderers - chosen male descendants of the original 10 - are allowed to cross to the wastelands, where they scavenge for detritus among the still-smoldering fires.

In this ferociously imaginative novel, abortion is once again illegal in America, in-vitro fertilization is banned, and the Personhood Amendment grants rights of life, liberty, and property to every embryo. In a small Oregon fishing town, five very different women navigate these new barriers alongside age-old questions surrounding motherhood, identity, and freedom.