Connie Nixon makes a shocking discovery: her youngest daughter, Jessica, now living in New York City, is part owner of a wildly successful sex toy shop. Startled by this knowledge, Connie sets out to reconnect with Jessica and finds herself living the life she's always dreamed about.

In the turbulent summer of 1974, Kate Mularkey has accepted her place at the bottom of the eighth-grade social food chain. Then, to her amazement, the "coolest girl in the world" moves in across the street and wants to be her friend. Tully Hart seems to have it all - beauty, brains, ambition. On the surface they are as opposite as two people can be: Kate, doomed to be forever uncool, with a loving family who mortifies her at every turn.

In 1985, Yale Tishman, the development director for an art gallery in Chicago, is about to pull off an amazing coup, bringing in an extraordinary collection of 1920s paintings as a gift to the gallery. Yet as his career begins to flourish, the carnage of the AIDS epidemic grows around him. One by one, his friends are dying and after his friend Nico's funeral, the virus circles closer and closer to Yale himself. Soon the only person he has left is Fiona, Nico's little sister.

Meghann Dontess is a woman haunted by heartbreak. Twenty-five years ago she was forced to make a terrible choice, one that cost her everything, including the love of her sister, Claire. Now, Meghann is a hotshot divorce attorney who doesn’t believe in intimacy - until she meets the one man who can change her mind.

In April 2002, Janine Latus' youngest sister, Amy, wrote a note and taped it to the inside of her desk drawer. "Today Ron Ball and I are romantically involved", it read, "but I fear I have placed myself at risk in a variety of ways. Based on his criminal past, writing this out just seems like the smart thing to do. If I am missing or dead this obviously has not protected me...."

Elizabeth and Jackson Shore married young, raised two daughters, and weathered the storms of youth as they built a future together. But after the children leave home, they quietly drift apart. When Jack accepts a wonderful new job offer, Elizabeth puts her needs aside to follow him across the country. Until the sudden death of her father changes everything.

Meredith Martin Delinn just lost everything: Her friends, her homes, her social standing - because her husband Freddy cheated rich investors out of billions of dollars. Desperate and facing homelessness, Meredith receives a call from her old best friend, Constance Flute. Connie's had recent worries of her own, and the two depart for a summer on Nantucket in an attempt to heal. But the island can't offer complete escape, and they're plagued by new and old troubles alike.

A warm June evening, a local tradition: The students of Nantucket High have gathered for a bonfire on the beach. But what begins as a graduation night celebration ends in tragedy after a horrible car crash leaves the driver of the car, Penny Alistair, dead and her twin brother in a coma. The other passengers - Penny's boyfriend Jake and her friend Demeter - are physically unhurt, but the emotional damage is overwhelming, and questions linger about what happened before Penny took the wheel.

Claire has a problem with setting limits. All her life she has taken on every responsibility, assumed every burden, granted every request. Claire wants it all—and in the eyes of her friends, she has it: a devoted husband, four beautiful children, even a successful career as an artist. So when she agrees to chair the committee for Nantucket's social event of the year, she knows she can handle it. Claire can handle anything. But when planning the gala propels her into the orbit of billionaire Lock Dixon, unexpected sparks begin to fly.

From marriage, infidelity, and the mayhem of motherhood to scandal, tragedy, and illness - three women seek peace and comfort in Nantucket as they cope with life's challenges. Three women - burdened with small children, unwieldy straw hats, and some obvious emotional issues - tumble onto the Nantucket airport tarmac one hot June day. Vicki is trying to sort through the news that she has a serious illness. Her sister, Brenda, has just left her job after being caught in an affair with a student. And their friend Melanie, after seven failed in vitro attempts, is pregnant at last.

Lucy and Owen, ambitious, thoroughly-therapized New Yorkers, have taken the plunge, trading in their crazy life in a cramped apartment for Beekman, a bucolic Hudson Valley exurb. They've got a 200-year-old house, an autistic son obsessed with the Titanic, and 17 chickens, at last count. It's the kind of paradise where stay-at-home moms team up to cook the school's "hot lunch", dads grill grass-fed burgers, and, as Lucy observes, "chopping kale has become a certain kind of American housewife's version of chopping wood".

High-school sweethearts Julia and Michael have left their humble West Virginia roots far behind for a glamorous life in Washington, D.C. As they achieve more in their careers - she as a high-end events planner, he as the CEO of his own sports-drink company - they lose themselves as a couple.

In 1962 a pregnant girl staggers into a health clinic, gives birth, and flees. A foster family takes the baby in, and an unlikely couple, their lives unspooling from the recent death of their infant, adopts her. Forty years and many secrets and lies later, Cheri Matzner is all grown up and falling apart. Ironic and fierce, she's a former cop turned disgruntled academic, a frustrated wife trying to get pregnant, an iconoclastic daughter bearing war wounds from her dysfunctional family.

Dr. Julie Walker wakes on a summer morning in San Francisco to find a city in chaos. Today Californians are voting on a controversial ballot initiative that will change history. With the future of the state and the nation uncertain, the streets have erupted into violence. Injured, Julie must make her way across the city by foot to the Veterans Administration Hospital, where her sister, recently returned from Afghanistan, is in labor. At the hospital a brutal scene is unfolding as a man who shares an intimate past with Julie begins to take his revenge.

Diana Cannon-Ragsdale was born into a Mormon dynasty. Her father Ted Cannon was a local celebrity in Salt Lake City, and her family’s ancestors were contemporaries of Brigham Young—and they had many dark secrets to keep. In Loose Cannons, Diana traces her rebellious 1970s girlhood—amidst her father’s multiple suicide attempts and remarriage to her mother’s sister. As she and her siblings barreled into adulthoods they weren’t ready for, they tried to rely on each other while reproducing broken relationships of their own.