When the father she barely knew dies suddenly, midwife Eve Wilson decides she owes it to him to go to the funeral and meet her step-family in Red Sand. After disappointment and heartbreak in Sydney, Dr Callie Wilson doesn't hesitate to move home and spend some time with her grieving mother. Melbourne-based obstetrician Sienna Wilson can't understand why anyone would want to bury themselves in the outback, but when her hospital sends her north to research the medical mystery affecting women in Red Sand, it seems fate is intent on bringing the three sisters together.

A single mum, Noni lives with her young son Harley, and her Aunt Win, a free spirit and the beating heart of Burra Guest House. Noni's world is disrupted when Iain McCloud and his pregnant teenage daughter Jacinta move into the guesthouse to await the birth of her baby. There's instant chemistry between Iain and Noni, although he has no plans to stay on in town. But when Jacinta shares explosive family secrets with Noni and an unexpected crisis occurs, everyone's lives come crashing down around them.

After her teenage daughter, Mia, falls in with the wrong crowd, Dr Billie Green decides it's time to leave the city and return home to Far Western NSW. When an opportunity to pursue her childhood dream of joining the Flying Doctor Service comes along, she jumps at the chance. Flight Nurse Daphne Prince - who is thrilled to have another woman join the otherwise male crew - and their handsome new boss, Morgan Blake, instantly make her feel welcome.

A year after a tragic accident changed her life forever, Tess Daley is in desperate need of a change. When she is offered a position with the Flying Doctor Service, she seizes the opportunity to make a fresh start. Yet once she arrives in remote Mica Ridge she feels like an outsider, unable to connect with her patients and unsure if she'll ever fit in with this outback community.

When outback midwife Ava May meets Zac on a flight to Alice Springs, they tumble into a whirlwind affair. But an exciting adventure leads to a terrible accident, with shattering consequences. The couple who had so much going for them now find themselves with everything to lose. Devastated, Ava retreats to her family cattle station to help salvage what she can of the critical situation. But at home on the drought-ridden farm, her brother is being pushed to his limits, and as his depression intensifies, Ava must step in to prevent another family tragedy.