From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.

Robert Sapolsky’s Behave, his now classic account of why humans do good and why they do bad, pointed toward an unsettling conclusion: We may not grasp the precise marriage of nature and nurture that creates the physics and chemistry at the base of human behavior, but that doesn’t mean it doesn’t exist. Now, in Determined, Sapolsky takes his argument all the way, mounting a brilliant (and in his inimitable way, delightful) full-frontal assault on the pleasant fantasy that there is some separate self telling our biology what to do.

Why do minds exist? How did mud and stone develop into beings that can experience longing, regret, love, and compassion - beings that are aware of their own experience? Until recently, science offered few answers to these existential questions. Journey of the Mind is the first book to offer a unified account of the mind that explains how consciousness, language, the Self, and civilization emerged incrementally out of chaos.

Argentine poet Jorge Luis Borges was madly in love when his life was shattered by painful heartbreak. But the breakdown that followed illuminated an incontrovertible truth—that love is necessarily imbued with loss, that the one doesn’t exist without the other. German physicist Werner Heisenberg was fighting with the scientific establishment on the meaning of the quantum realm’s absurdity when he had his own epiphany—that there is no such thing as a complete, perfect description of reality.

We often think of mathematics and literature as polar opposites. But what if, instead, they were fundamentally linked? In her clear, insightful, laugh-out-loud funny debut, Once Upon a Prime, Professor Sarah Hart shows us the myriad connections between math and literature, and how understanding those connections can enhance our enjoyment of both. As the first woman to hold England’s oldest mathematical chair, Professor Hart is the ideal tour guide, taking us on an unforgettable journey through the books we thought we knew, revealing new layers of beauty and wonder.

Benjamín Labatut’s When We Cease to Understand the World electrified a global readership. A Booker Prize and National Book Award finalist, and one of the New York Times’ Ten Best Books of the Year, it explored the life and thought of a clutch of mathematicians and physicists who took science to strange and sometimes dangerous new realms. In The MANIAC, Labatut has created a tour de force on an even grander scale.

When We Cease to Understand the World is a book about the complicated links between scientific and mathematical discovery, madness, and destruction. Fritz Haber, Alexander Grothendieck, Werner Heisenberg, Erwin Schrödinger - these are some of the luminaries into whose troubled lives Benjamín Labatut thrusts the listener, showing us how they grappled with the most profound questions of existence.

Humanism is an expansive tradition of thought that places shared humanity, cultural vibrancy, and moral responsibility at the center of our lives. For centuries, this worldview has inspired people to make their choices by principles of freethinking, intellectual inquiry, fellow feeling, and optimism. In this sweeping new history, Sarah Bakewell, herself a lifelong humanist, illuminates the very personal, individual, and, well, human matter of humanism and takes listeners on a grand intellectual adventure.

The Earth teems with sights and textures, sounds and vibrations, smells and tastes, electric and magnetic fields. But every kind of animal, including humans, is enclosed within its own unique sensory bubble, perceiving but a tiny sliver of our immense world. In An Immense World, Ed Yong coaxes us beyond the confines of our own senses, allowing us to perceive the skeins of scent, waves of electromagnetism, and pulses of pressure that surround us.

Five-year-old Milad Salama is excited for a school trip to a theme park on the outskirts of Jerusalem. On the way, his bus collides with a semitrailer. His father, Abed, gets word of the crash and rushes to the site. The scene is chaos—the children have been taken to different hospitals in Jerusalem and the West Bank; some are missing, others cannot be identified. Abed sets off on an odyssey to learn Milad’s fate. It is every parent’s worst nightmare, but for Abed it is compounded by the maze of physical, emotional, and bureaucratic obstacles he must navigate because he is Palestinian.

The smartphones in our pockets and computers like brains. The vagaries of game theory and evolutionary biology. Nuclear weapons and self-replicating spacecrafts. All bear the fingerprints of one remarkable, yet largely overlooked, man: John von Neumann.

For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight-how the same simple chemistry gives rise to life and causes our demise.

We feel, therefore we are. Conscious sensations ground our sense of self. They are crucial to our idea of ourselves as psychic beings: present, existent, and mattering. But is it only humans who feel this way? Do other animals? Will future machines? Weaving together intellectual adventure and cutting-edge science, Nicholas Humphrey describes in Sentience his quest for answers: from his discovery of blindsight in monkeys and his pioneering work on social intelligence to breakthroughs in the philosophy of mind.

From the creation of the first encyclopedia to Wikipedia, from ancient museums to modern kindergarten classes—this is Simon Winchester’s brilliant and all-encompassing look at how humans acquire, retain, and pass on information and data, and how technology continues to change our lives and our minds. Throughout this fascinating tour, Winchester forces us to ponder what rational humans are becoming. What good is all this knowledge if it leads to lack of thought? What is information without wisdom?

Breathless is story of SARs-CoV-2 and its fierce journey through the human population, as seen by the scientists who study its origin, its ever-changing nature, and its capacity to kill us. David Quammen expertly shows how strange new viruses emerge from animals into humans as we disrupt wild ecosystems and how those viruses adapt to their human hosts, sometimes causing global catastrophe. He explains why this coronavirus will probably be a “forever virus,” destined to circulate among humans and bedevil us endlessly, in one variant form or another.

When did we begin to be as self-centered as we are today? At what point did we expect to have the right to determine our own lives? When did we first ask the question, how can I be free? It all began in the 1790s in a quiet university town in Germany when a group of playwrights, poets, and writers put the self at center stage in their thinking, writing, and their lives.

In 1875, tuberculosis was the deadliest disease in the world, accountable for a third of all deaths. A diagnosis of TB - often called consumption - was a death sentence. Then, in a triumph of medical science, a German doctor named Robert Koch deployed an unprecedented scientific rigor to discover the bacteria that caused TB. Koch soon embarked on a remedy - a remedy that would be his undoing. When Koch announced his cure for consumption, Arthur Conan Doyle, then a small-town doctor in England and sometime writer, went to Berlin to cover the event.

The history of European philosophy is usually constructed from the work of men. In Metaphysical Animals, a pioneering group biography, Clare Mac Cumhaill and Rachael Wiseman offer a compelling alternative. In the mid-twentieth century Elizabeth Anscombe, Mary Midgley, Philippa Foot, and Iris Murdoch were philosophy students at Oxford when most male undergraduates and many tutors were conscripted away to fight in the Second World War. Together, these young women, all friends, developed a philosophy that could respond to the war’s darkest revelations.

In The Knife Man, Wendy Moore unveils John Hunter's murky and macabre world - a world characterized by public hangings, secret expeditions to dank churchyards, and gruesome human dissections in pungent attic rooms. This is a fascinating portrait of a remarkable pioneer and his determined struggle to haul surgery out of the realms of meaningless superstitious ritual and into the dawn of modern medicine.

From the best-selling author of Gratitude and On the Move, a final volume of essays that showcase Sacks's broad range of interests - from his passion for ferns, swimming, and horsetails, to his final case histories exploring schizophrenia, dementia, and Alzheimer's.

Nietzsche wrote that all philosophy is autobiographical, and in this vividly compelling, myth-shattering biography, Sue Prideaux brings listeners into the world of this brilliant, eccentric, and deeply troubled man, illuminating the events and people that shaped his life and work. I Am Dynamite! is the essential biography for anyone seeking to understand history's most misunderstood philosopher.

In The Butchering Art, the historian Lindsey Fitzharris reveals the shocking world of 19th-century surgery on the eve of profound transformation. She conjures up early operating theaters - no place for the squeamish - and surgeons, working before anesthesia, who were lauded for their speed and brute strength. They were baffled by the persistent infections that kept mortality rates stubbornly high. A young, melancholy Quaker surgeon named Joseph Lister would solve the deadly riddle and change the course of history.

Rosalind Franklin was what can only be called an overlooked genius. Although she was not fully credited for the feat at the time, her work led to major breakthroughs in our understanding of DNA. In fact, she took the first X-ray photo of DNA in all of its double helix glory. By the time her former colleagues were being showered with accolades for results they made at least partially based on her findings, Franklin would not be around to see it. Sadly, it’s believed that her use of X-ray equipment gave her terminal cancer, cutting her life short at age 37.

When Dr. David Hosack tilled the country's first botanical garden in the Manhattan soil more than 200 years ago, he didn't just dramatically alter the New York landscape; he left a monumental legacy of advocacy for public health and wide-ranging support for the sciences. In melodic prose, historian Victoria Johnson eloquently chronicles Hosack's tireless career to reveal the breadth of his impact. The result is a lush portrait of the man who gave voice to a new, deeply American understanding of the powers and perils of nature.

No cloistered don, this tall, married Englishman was a freethinking intellectual, who practiced nudism and was devoted to a quirky brand of folk dancing. In 1937, while working as a biochemist at Cambridge University, he instantly fell in love with a visiting Chinese student, with whom he began a lifelong affair. He soon became fascinated with China, and his mistress swiftly persuaded the ever-enthusiastic Needham to travel to her home country, where he embarked on a series of extraordinary expeditions to the farthest frontiers of this ancient empire.

The stunning story of the breathtaking journey of nine extraordinary men from Budapest to the New World, what they experienced along their dangerous route, and how they changed America and the world. In a style both personal and historically groundbreaking, acclaimed author Kati Marton (born in Budapest) tells the tale of their youth in Budapest's Golden Age of the early 20th century, their flight, and their lives of extraordinary accomplishment, danger, glamour, and poignancy.

Paris, 1933: Three contemporaries meet over apricot cocktails at the Bec-de-Gaz bar on the rue Montparnasse. They are the young Jean-Paul Sartre, Simone de Beauvoir, and longtime friend Raymond Aron, a fellow philosopher who raves to them about a new conceptual framework from Berlin called phenomenology. "You see," he says, "if you are a phenomenologist, you can talk about this cocktail and make philosophy out of it!"

The Greater Journey is the enthralling, inspiring—and until now, untold—story of the adventurous American artists, writers, doctors, politicians, architects, and others of high aspiration who set off for Paris in the years between 1830 and 1900, ambitious to excel in their work.

Paul Dirac was among the great scientific geniuses of the modern age. One of the discoverers of quantum mechanics, the most revolutionary theory of the past century, his contributions had a unique insight, eloquence, clarity, and mathematical power. His prediction of antimatter was one of the greatest triumphs in the history of physics.

On a brutal winter's day in 1650 in Stockholm, Frenchman Rene Descartes, the most influential and controversial thinker of his time, was buried after a cold and lonely deathfar from home. Sixteen years later, the pious French Ambassador Hugues de Terlon secretly unearthed Descartes' bones and transported them to France. Why would this devoutly Catholic official care so much about the remains of a philosopher who washounded from country after country on charges of atheism?