Alexander (better known as “Sasha”) and Ann Shulgin’s PiHKAL: A Chemical Love Story has become a foundational work in the genre and was the first book to fully impart the how-to chemistry, and convey the effects, of many of the entheogenic drugs that are currently being studied and used to heal trauma and deal with death.

The Way of the Psychonaut, Volumes 1 and 2 is one of the most important books ever written about the human psyche and the spiritual quest. The new understandings were made possible thanks to Albert Hofmann’s discovery of LSD―the microscope and telescope of the human psyche―as well as other psychedelic substances.

This is the story of LSD told by a concerned yet hopeful father, organic chemist Albert Hofmann, PhD. He traces LSD's path from a promising psychiatric research medicine to a recreational drug sparking hysteria and prohibition. In LSD: My Problem Child, we follow Dr. Hofmann's trek across Mexico to discover sacred plants related to LSD, and listen in as he corresponds with other notable figures about his remarkable discovery.

When Michael Pollan set out to research how LSD and psilocybin (the active ingredient in magic mushrooms) are being used to provide relief to people suffering from difficult-to-treat conditions such as depression, addiction, and anxiety, he did not intend to write what is undoubtedly his most personal book. But upon discovering how these remarkable substances are improving the lives not only of the mentally ill but also of healthy people coming to grips with the challenges of everyday life, he decided to explore the landscape of the mind in the first person as well as the third.

A groundbreaking dive into the role psychedelics have played in the origins of Western civilization, and the real-life quest for the Holy Grail that could shake the Church to its foundations.

This mesmerizing, surreal account of the bizarre adventures of Terence McKenna, his brother Dennis, and a small band of their friends, is a wild ride of exotic experience and scientific inquiry. Exploring the Amazon Basin in search of mythical shamanic hallucinogens, they encounter a host of unusual characters - including a mushroom, a flying saucer, pirate Mantids from outer space, an appearance by James and Nora Joyce in the guise of poultry, and translinguistic matter - and discover the missing link in the development of human consciousness and language.

Called “America’s wisest and most respected authority on psychedelics and their use,” James Fadiman has been involved with psychedelic research since the 1960s. In this guide to the immediate and long-term effects of psychedelic use for spiritual (high dose), therapeutic (moderate dose), and problem-solving (low dose and microdose) purposes, Fadiman outlines best practices for safe, sacred entheogenic voyages learned through his more than 40 years of experience.

From 1990 to 1995 Dr. Rick Strassman conducted U.S. Government-approved and funded clinical research at the University of New Mexico in which he injected 60 volunteers with DMT, one of the most powerful psychedelics known. His detailed account of those sessions is an extraordinarily riveting inquiry into the nature of the human mind and the therapeutic potential of psychedelics. DMT, a plant-derived chemical found in the psychedelic Amazon brew, ayahuasca, is also manufactured by the human brain. In Strassman's volunteers, it consistently produced near-death and mystical experiences.

Of all the things humans rely on plants for - sustenance, beauty, medicine, fragrance, flavor, fiber - surely the most curious is our use of them to change consciousness: to stimulate or calm, fiddle with or completely alter, the qualities of our mental experience. Take coffee and tea: People around the world rely on caffeine to sharpen their minds. But we do not usually think of caffeine as a drug, or our daily use as an addiction, because it is legal and socially acceptable.

Journey alongside professor Bache as he touches the living intelligence of our universe - an intelligence that both embraced and crushed him - and demonstrates how direct experience of the divine can change your perspective on core issues in philosophy and religion. Chronicling his 73 sessions, the author reveals the spiral of death and rebirth that took him through the collective unconscious into the creative intelligence of the universe.

Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

Bill Bryson once again proves himself to be an incomparable companion as he guides us through the human body - how it functions, its remarkable ability to heal itself, and (unfortunately) the ways it can fail. Full of extraordinary facts (your body made a million red blood cells since you started reading this) and irresistible Bryson-esque anecdotes, The Body will lead you to a deeper understanding of the miracle that is life in general and you in particular. As Bill Bryson writes, "We pass our existence within this wobble of flesh and yet take it almost entirely for granted."

Exploring the latest developments in the flourishing field of modern psychedelic psychotherapy, this book shares practical experiences and insights from both elders and newer research voices in the psychedelic research and clinical communities.

A magnificently reported and soulfully crafted exploration of the human immune system - the key to health and wellness, life and death. An epic, first-of-its-kind audiobook, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize-winning New York Times journalist.

In an ambitious and comprehensive look at psilocybin—and an inside look at how humanity co-evolved alongside "magic" mushrooms—Jahan Khamsehzadeh, PhD, explores our historical and ancestral relationship to psychedelics and presents new and exciting research about what psilocybin can mean for us today.

While serving with the Peace Corps in Swaziland, Thomas Cowan encountered the work of Rudolf Steiner and Weston A. Price - two men whose ideas would fascinate and challenge him for decades to come. Both drawn to the art of healing and repelled by the way medicine was - and continues to be - practiced in the United States, Cowan returned from Swaziland, went to medical school, and established a practice.

Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

In Drugged, Miller takes listeners on an eye-opening tour of psychotropic drugs, describing the various kinds, how they were discovered and developed, and how they have played multiple roles in virtually every culture. Drugged brims with surprises, revealing the fact that antidepressant drugs evolved from rocket fuel, highlighting the role of hallucinogens in the history of religion, and asking whether Prozac can help depressed cats. Entertaining and authoritative, Drugged is a truly fascinating book.

When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way - an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease.

Published in partnership with the International Association for the Study of Pain, A Nation in Pain offers a sweeping, deeply researched account of the chronic pain crisis, from neurobiology to public policy, and presents practical solutions that are within our grasp today. Drawing on both her personal experience with chronic pain and her background as an award-winning health journalist, she guides us through recent scientific discoveries, including genetic susceptibility to pain.

We humans like to think of ourselves as highly evolved creatures. But if we are supposedly evolution's greatest creation, why do we have such bad knees? Why do we catch head colds so often - 200 times more often than a dog does? How come our wrists have so many useless bones? And are we really supposed to swallow and breathe through the same narrow tube? Surely there's been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last.

The author of the highly acclaimed Overdiagnosed describes seven widespread assumptions that encourage excessive, often ineffective, and sometimes harmful medical care. You might think the biggest problem in medical care is that it costs too much. Or that health insurance is too expensive, too uneven, too complicated - and gives you too many forms to fill out. But the central problem is that too much medical care has too little value.

One out of three women alive today, and one out of two men, will face a cancer diagnosis, according to the World Health Organization. Ty Bollinger takes this personally: in the course of a decade, he says, "I lost my entire family to cancer. I don't believe I had to lose them." The Truth about Cancer has been written for one simple reason: to share the knowledge we need to protect ourselves, treat ourselves, and in some cases save our lives or the lives of those we love.

What won't we try in our quest for perfect health, beauty, and the fountain of youth? Well, just imagine a time when doctors prescribed morphine for crying infants. When liquefied gold was touted as immortality in a glass. And when strychnine - yes, that strychnine, the one used in rat poison - was dosed like Viagra. Looking back with fascination, horror, and not a little dash of dark, knowing humor, Quackery recounts the lively, at times unbelievable, history of medical misfires and malpractices.

Each of us will know physical pain in our lives, but none of us knows when it will come or how long it will stay. Today as much as 10 percent of the population of the United States suffers from chronic pain. It is more widespread, misdiagnosed, and undertreated than any major disease. While recent research has shown that pain produces pathological changes to the brain and spinal cord, many doctors and patients still labor under misguided cultural notions and outdated scientific dogmas.

Sleep. Memory. Pleasure. Fear. Language. We experience these things every day, but how do our brains create them? Your Brain, Explained is a personal tour around your gray matter. Neuroscientist Marc Dingman gives you a crash course in how your brain works and explains the latest research on the brain functions that affect you on a daily basis. You'll also discover what happens when the brain doesn't work the way it should, causing problems such as insomnia, ADHD, depression, or addiction.

Important and provocative, The Undead examines why even with the tools of advanced technology, what we think of as life and death, consciousness and nonconsciousness, is not exactly clear - and how this problem has been further complicated by the business of organ harvesting.

Happy Accidents is a fascinating, entertaining, and highly accessible look at the surprising role serendipity has played in some of the most important medical discoveries in the 20th century. What do penicillin, chemotherapy drugs, X-rays, Valium, the Pap smear, and Viagra have in common? They were each discovered accidentally, stumbled upon in the search for something else. In discussing medical breakthroughs, Dr. Morton Meyers makes a cogent, highly engaging argument for a more creative, rather than purely linear, approach to science. And it may just save our lives!

Wondering whether eating powdered mummies might be just the thing to cure your ills? Tempted by those vintage ads suggesting you wear radioactive underpants for virility? Ever considered drilling a hole in your head to deal with those pesky headaches? Probably not. But for thousands of years, people have done things like this - and things that make radioactive underpants seem downright sensible! In their hit podcast, Sawbones, Sydnee and Justin McElroy breakdown the weird and wonderful way we got to modern healthcare. And some of the terrifying detours along the way.

How come I can never find my keys? Why don't I sleep as well as I used to? Why do my friends keep repeating the same stories? What can I do to keep my brain sharp? Scientists know. Brain Rules for Aging Well, by developmental molecular biologist Dr. John Medina, gives you the facts - and the prescription to age well - in his signature engaging style. With so many discoveries over the years, science is literally changing our minds about the optimal care and feeding of the brain. All of it is captivating. A great deal of it is unexpected.

Can beliefs make you sick? Consider "The June Bug" incident from a US textile factory in the early 1960s. Many employees began to feel dizzy, had an upset stomach, and vomited. Some were even hospitalized. The illness was attributed to a mysterious bug biting workers. However, when the CDC investigated this outbreak, no bugs or any other cause of the illnesses could be identified. Instead, it appears to be an illness caused by the mind -- that is, sickness due to expectation.

It is rare for life to change Earth, yet three organisms have profoundly transformed our planet over the long course of its history. Elemental reveals how microbes, plants, and people used the fundamental building blocks of life to alter the climate, and with it, the trajectory of life on Earth in the past, present, and future. Taking listeners from the deep geologic past to our current era of human dominance, Stephen Porder focuses on five of life’s essential elements—hydrogen, oxygen, carbon, nitrogen, and phosphorus.

In The Secrets of Alchemy, Lawrence M. Principe, one of the world's leading authorities on the subject, brings alchemy out of the shadows and restores it to its important place in human history and culture. By surveying what alchemy was and how it began, developed, and overlapped with a range of ideas and pursuits, Principe illuminates the practice. He vividly depicts the place of alchemy during its heyday in early modern Europe, and then explores how alchemy has fit into wider views of the cosmos and humanity.

For most of history, humans did without refined sugar. Granulated sugar was first produced in India around the sixth century BC, yet for almost 2,500 years afterward sugar remained marginal in the diets of most people. Then, suddenly, it was everywhere. How did sugar find its way into almost all the food we eat, fostering illness and ecological crisis along the way? The World of Sugar begins with the earliest evidence of sugar production.

Tristan Gooley helps listeners reconnect with nature by finding direction and searching for hidden clues in stars, clouds, water and more. Now, he turns his attention to perhaps nature’s most beloved feature – the stately, majestic tree. Every single tree tells us an epic story – if we know how to read it! Here you’ll discover hundreds of astonishing secrets hiding in plain sight among the living network of branches, trunks, roots, bark, leaves, buds, flowers, stumps and more.

Sourdough bread fueled the labor that built the Egyptian pyramids. The Roman Empire distributed free sourdough loaves to its citizens to maintain political stability. More recently, amidst the COVID-19 pandemic, sourdough bread baking became a global phenomenon as people contended with being confined to their homes and sought distractions from their fear, uncertainty, and grief. In Sourdough Culture, environmental science professor Eric Pallant shows how throughout history, sourdough bread baking has always been about survival.

The Blind Spot goes where no science book goes, urging us to create a new scientific culture that views ourselves both as an expression of nature and as a source of nature's self-understanding, so that humanity can flourish in the new millennium.

For centuries, people have been returning to the same tired nature-versus-nurture debate, trying to determine what we learn and what we inherit. In Dancing Cockatoos and the Dead Man Test, biologist Marlene Zuk goes beyond the binary and instead focuses on interaction, or the way that genes and environment work together. Driving her investigation is a simple but essential question: How does behavior evolve?

In this tour of the animal kingdom, evolutionary biologist Lee Alan Dugatkin reveals a new field of study, uncovering social networks that existed long before the dawn of human social media. He accessibly describes the latest findings from animal behavior, evolution, computer science, psychology, anthropology, genetics, and neurobiology, and incorporates interviews and insights from researchers he finds swimming with manta rays, avoiding pigeon poop, and stopping monkeys from stealing iPads.

The Japanese roleplaying game (JRPG) genre is one that is known for bold, unforgettable characters; rich stories; and some of the most iconic and beloved games in the industry. Inspired by early Western RPGs and introducing technology and artistic styles that pushed the boundaries of what video games could be, this genre is responsible for creating some of the most complex, bold, and beloved games in history. In Fight, Magic, Items, Aidan Moher guides listeners through the history of JRPGs.