Jack Kernigan is having a bad day...a bad year...a bad life. After being booted out of MIT, he’s back in his Ohio hometown, working for the family business, facing a life of mediocrity. Then one day, out on a delivery, his truck hits...something. Something big...something furry...something invisible. And, it turns out, something not of this Earth. Fate can play funny tricks. Which is why Jack suddenly finds himself the planet’s best hope to unravel a conspiracy of galactic proportions that could spell the end of the human race.

In Atlanta, Dr. Peyton Shaw is awakened by the phone call she has dreaded for years. As the CDC's leading epidemiologist, she's among the first responders to outbreaks around the world. It's a lonely and dangerous job, but it's her life - and she's good at it. This time she may have met her match. In Kenya, an Ebola-like pathogen has infected two Americans. One lies at death's door. With the clock ticking, Peyton assembles her team and joins personnel from the Kenyan Ministry of Health and the WHO.

Everyone thinks Emmy Dockery is crazy. Obsessed with finding the link between hundreds of unsolved cases, Emmy has taken leave from her job as an FBI researcher. Now all she has are the newspaper clippings that wallpaper her bedroom, and her recurring nightmares of an all-consuming fire. Not even Emmy's ex-boyfriend, field agent Harrison "Books" Bookman, will believe her that hundreds of kidnappings, rapes, and murders are all connected.

Dr. Chris Shepard has never seen his new patient before. But the attractive young woman with the scarred face knows him all too well. An FBI agent working undercover, Alex Morse has come to Dr. Shepard’s office in Natchez, Mississippi, to unmask a killer. A local divorce attorney has a cluster of clients whose spouses have all died under mysterious circumstances. Agent Morse’s own brother-in-law was one of those clients, and now her beloved sister is dead.

Tia and Mike Baye never imagined they'd become the type of overprotective parents who spy on their kids. But their 16-year-old son, Adam, has been unusually distant lately, and after the suicide of his classmate, Spencer Hill they can't help but worry. They install a sophisticated spy program on Adam's computer, and within days they are jolted by a message from an unknown correspondent addressed to their son: "Just stay quiet and all safe."

Meanwhile, Betsy Hill is struck by a photo that appears to have been taken on the night of her son's death...and he wasn't alone.

Christine Nilsson and her husband, Marcus, are desperate for a baby. Unable to conceive, they find themselves facing a difficult choice they had never anticipated. After many appointments with specialists, endless research, and countless conversations, they make the decision to use a donor.

They’re one of the country’s most telegenic couples: beloved TV journalist Sara Lowell and New York’s hottest basketball star, Michael Silverman. Their family and social connections tie them to the highest echelons of the political, medical, and sports worlds - threads that will tangle them up in one of the most controversial and deadly issues of our time. In a clinic on Manhattan’s Upper West Side, a doctor has dedicated his life to eradicating a divisive and devastating disease. One by one, his patients are getting well.

When Hazel Nash was six years old, her father taught her: Mysteries need to be solved. He should know. Hazel's father is Jack Nash, the host of America's favorite conspiracy TV show, The House of Secrets. Even as a child, she loved hearing her dad's tall tales, especially the one about a leather book belonging to Benedict Arnold that was hidden in a corpse. Now, years later, Hazel wakes up in the hospital and remembers nothing, not even her own name. She's told she's been in a car accident that killed her father and injured her brother.

George Wilson, M.D., a radiology resident in Los Angeles, is about to enter a profession on the brink of an enormous paradigm shift, foreshadowing a vastly different role for doctors everywhere. The smartphone is poised to take on a new role in medicine, no longer as a mere medical app but rather as a fully customizable personal physician capable of diagnosing and treating even better than the real thing. It is called iDoc. George's initial collision with this incredible innovation is devastating.

Harmony House is more than a “special place for special people.” It’s a think tank where high-functioning autistic savants harness their unique abilities for the benefit of society. Resident Eddie Parks’s contribution: an “echo box” that can re-create never-recorded sounds using acoustic archeology. All Eddie wants is to hear his late mother’s voice. But what he’s created is inadvertently posing a threat to national security. To Harmony House’s shadowy government backers and radical extremists, the echo box is the ultimate intelligence asset - an end to the very concept of secrecy.

In June 2021, a senseless event upends the lives of hundreds of men and women, all passengers on a flight from Paris to New York. Among them: Blake, a respectable family man, though he works as a contract killer; Slimboy, a Nigerian pop star tired of living a lie; Joanna, a formidable lawyer whose flaws have caught up with her; and Victor Miesel, a critically acclaimed yet commercially unsuccessful writer who suddenly becomes a cult hit. All of them believed they had double lives. None imagined just how true that was.

Delaney Wells is an unlikely new hire at the Every. A former forest ranger and unwavering tech skeptic, she charms her way into an entry-level job with one goal in mind: to take down the company from within. With her compatriot, the not-at-all-ambitious Wes Makazian, they look for the Every's weaknesses, hoping to free humanity from all-encompassing surveillance and the emoji-driven infantilization of the species. But does anyone want what Delaney is fighting to save? Does humanity truly want to be free?

In a world where the slightest edge can mean the difference between success and failure, Leisha Camden is beautiful, extraordinarily intelligent, and one of a growing number of human beings who have been genetically modified to never require sleep. Once considered interesting anomalies, now Leisha and the other "Sleepless" are outcasts, victims of blind hatred, political repression, and shocking mob violence meant to drive them from human society and, ultimately, from Earth itself.

In the heart of North Carolina's Research Triangle stands a corporate laboratory much like the others nearby. But behind its walls, America's top scientists work around the clock to attain the holy grail of the 21st century - a supercomputer that surpasses the power of the human mind.

Attacked and injected with a drug that slows his metabolism to a fraction of normal, Martin James becomes an unwilling time traveler who hurtles through the years. His children grow up, his wife grows older, and his only hope is finding the people who injected him in the first place - not an easy task when one day for Martin lasts four years. And while Martin James strives to find a cure before everyone he loves is gone, others are uncertain if his journey can be stopped at all.