Midwife Patience Murphy has a gift: a talent for escorting mothers through the challenges of bringing children into the world. Working in the hardscrabble conditions of Appalachia during the Depression, Patience takes the jobs that no one else wants, helping those most in need - and least likely to pay. She knows a successful midwifery practice must be built on a foundation of openness and trust - but the secrets Patience is keeping are far too intimate and fragile for her to ever let anyone in.

Heather is pale and thin, seventeen and pregnant with twins when Patricia Harman begins to care for her. Over the course of the next five seasons Patsy will see Heather through the loss of both babies and their father. She will also care for her longtime patient Nila, pregnant for the eighth time and trying to make a new life without her abusive husband. And Patsy will try to find some comfort to offer Holly, whose teenage daughter struggles with bulimia. She will help Rebba learn to find pleasure in her body and help Kaz transition into a new body.

In the rugged Pacific Northwest lies the Olympic National Forest - nearly a million acres of impenetrable darkness and impossible beauty. From deep within this old growth forest, a six-year-old girl appears. Speechless and alone, she offers no clue as to her identity, no hint of her past.

For nearly 200 years, women in Ashley Tolliver's family have practiced the art of midwifery in their mountain community. Now she wants to take her skills a step further, but attending medical school means abandoning those women to whom she has dedicated her life, the mountains she loves, and the awakening of her heart.

Anne Gallagher grew up enchanted by her grandfather’s stories of Ireland. Heartbroken at his death, she travels to his childhood home to spread his ashes. There, overcome with memories of the man she adored and consumed by a history she never knew, she is pulled into another time. The Ireland of 1921, teetering on the edge of war, is a dangerous place in which to awaken. But there Anne finds herself, hurt, disoriented, and under the care of Dr. Thomas Smith, guardian to a young boy who is oddly familiar.

Josie Bianci was killed years ago on a train during a terrorist attack. Gone forever. It’s what her sister, Kit, an ER doctor in Santa Cruz, has always believed. Yet all it takes is a few heart-wrenching seconds to upend Kit’s world. Live coverage of a club fire in Auckland has captured the image of a woman stumbling through the smoke and debris. Her resemblance to Josie is unbelievable. And unmistakable. With it comes a flood of emotions - grief, loss, and anger - that Kit finally has a chance to put to rest: by finding the sister who’s been living a lie.

Ana Kaminski is pushed through the iron gates of Auschwitz beside her frightened young friend Ester Pasternak. As they reach the front of the line, Ana steps forward and quietly declares herself a midwife--and Ester her assistant. Their arms are tattooed and they’re ordered to the maternity hut. Holding an innocent newborn baby, Ana knows the fate of so many are in her hands and vows to do everything she can to save them.

Venice, 1736. When fate brings Violetta and Mino together on the roof of the Hospital of the Incurables, they form a connection that will change their lives forever. Both are orphans at the Incurables, dreaming of escape. But when the resident Maestro notices Violetta's voice, she is selected for the Incurables' world famous coro, and must sign an oath never to sing beyond its church doors. After a declaration of love ends in heartbreak, Mino flees the Incurables in search of his family. Venice is full of secrets, and Mino is certain one will lead to his long-lost mother.

Her beauty almost certainly saved her from the rising Nazi party and led to marriage with an Austrian arms dealer. Underestimated in everything else, she overheard the Third Reich's plans while at her husband's side, understanding more than anyone would guess. She devised a plan to flee in disguise from their castle, and the whirlwind escape landed her in Hollywood. She became Hedy Lamarr, screen star.

Sofia Colicchio is a free spirit, loud and untamed. Antonia Russo is thoughtful, ever observing the world around her. Best friends since birth, they live in the shadow of their fathers’ unspoken community: the Family. Sunday dinners gather them each week to feast, discuss business, and renew the intoxicating bond borne of blood and love. But the disappearance of Antonia’s father drives a whisper-thin wedge between the girls as they grow into women, wives, mothers, and leaders. One fateful night, their loyalty to each other and the Family will be tested.

Marian Engström has found her true calling: working with rescue dogs to help protect endangered wildlife. Her first assignment takes her to Northern Alberta, where she falls in love with her mentor, the daring and brilliant Tate. When they’re separated on another assignment, she’s shattered to learn of his tragic death. Before long, Marian discovers disturbing inconsistencies about Tate’s life and begins to wonder if the man she loved could have been responsible for the unsolved murders of at least four women.

At the age of 22, Jennifer Worth left her comfortable home to move into a convent and become a midwife in postwar London’s East End slums. The colorful characters she met while delivering babies all over London - from the plucky, warm-hearted nuns with whom she lived to the woman with 24 children who couldn't speak English to the prostitutes and dockers of the city’s seedier side - illuminate a fascinating time in history.

In the summer of 1862, a group of young artists led by the passionate and talented Edward Radcliffe descends upon Birchwood Manor in rural Oxfordshire. Their plan: to spend a secluded summer month in a haze of inspiration and creativity. But by the time their stay is over, one woman has been shot dead while another has disappeared; a priceless heirloom is missing; and Edward Radcliffe’s life is in ruins. Over 150 years later, Elodie Winslow, a young archivist in London, uncovers a leather satchel containing two seemingly unrelated items.

In a windswept British seaside town, single mum Alice Lake finds a man sitting on the beach outside her house. He has no name and no idea how he got there. Against her better judgment, she invites him inside. Meanwhile, in a suburb of London, 21-year-old Lily Monrose has been married for only three weeks. When her husband fails to come home from work one night, she is left alone in a place where she knows no one and with the police telling her that her husband never existed.

In the fall of 1957, Olivia McAlister is living in Opelika, Mississippi, caring for her two girls, June and Grace, and her husband, Holly. She dreams of living a much larger life - seeing the world and returning to her wartime job at a landing boat factory in New Orleans. As she watches over the birds in her yard, Olivia feels like an “accidental” - a migratory bird blown off course. When Olivia becomes pregnant again, she makes a fateful decision, compelling Grace, June, and Holly to cope in different ways.