This year marks the 400th anniversary of Galileo’s use of the first telescope. On this week’s show, we reflect on how telescopes have changed our perception of our place in the universe, how small we are in size, space, and time. Our guests include Dava Sobel, author of The Planets, Vatican Astronomer Father Chris Corbally, and astronaut Paul Richards.

Mark Twain said, “Get your facts first, then you can distort them as you please.” Pseudoscience adheres to this adage, but are their distortions deliberate, the result of scientific ignorance, or due to a deep desire for extraordinary possibilities? In our quest to understand the universe, how can we be sure our conclusions are correct? Human beings have evolved to find meaningful patterns in nature, but sometimes the patterns we see are just figments of our imagination — or perhaps the result of wishful thinking.

Richard Branson has formed Virgin Galactic and is now taking reservations aboard the maiden voyage of SpaceShipOne. Would you spend the estimated $200,000 for a 45-minute trip into space? Neil and Lynne also discuss the mechanics of sex in space.

The Star Trek TV and movie series imagine a bright future for humans in space, one in which we explore alien worlds with the aid of advanced technology. Because the writers tried to include as much realistic science as possible within the fictional framework, the stories have been an inspiration for students, scientists, inventors, and anyone interested in pondering our destiny on Earth and beyond. In this show, Brandon Fibbs reviews a Star Trek movie, and Lawrence Krauss talks about how Star Trek uses science to explore what is possible in our universe.

Could you travel to the past and visit Julius Caesar? Could you travel to the year 4000 and see what the future is like? Find out about the possibilities and paradoxes of time travel. Time marches on except in astrophysics. Einstein taught us that time is a coordinate in space, and it’s all relative. Learn about the weird physics of our universe that could make time travel possible. Standing in for Lynne Koplitz this week is J. Richard Gott, III, author of Time Travel in Einstein’s Universe.

In this illuminating audiobook, Tyson and coauthor James Trefil, a renowned physicist and science popularizer, take on the big questions that humanity has been posing for millennia - How did life begin? What is our place in the universe? Are we alone? - and provide answers based on the most current data, observations, and theories.

"That’s one small step for man, one giant leap for mankind." Neil Armstrong spoke these words after placing his foot down onto lunar soil, and throughout the course of the Apollo program, 11 other astronauts also walked on the Moon. In this show, Neil Armstrong, Buzz Aldrin, and many others share their memories of Apollo, and say what they think should be NASA’s next step in space.

Attempts by scientists and artists to reveal deep truths about the universe may take different forms, but they often end up agreeing with the poet John Keats that “truth is beauty”. Geometry, physics, and the other sciences describe the world we live in, and artists often play with these properties in their own imaginative investigations. From the drawings of Leonardo Da Vinci to high tech computer graphics, Neil and Lynne paint a picture of how science has inspired art through the ages.

Special guest Stephen Colbert of Comedy Central’s Colbert Report talks about the joys of being a science geek. Brilliant scientific discoveries and cutting edge technology have transformed our world, yet many people are turned off by science. Where has the excitement for science gone, and how can we get it back? Stephen Colbert developed an interest in science at a young age, and now he shares that fascination by inviting scientists to appear on his show The Colbert Report.

Space is now big business. Technology originally developed for the space program sometimes ends up in products for use on Earth, often in surprising ways. The 40,000 certified “Space Products” range from mattresses to medical devices, and have turned space into a multi-billion-dollar industry. Inspired by our excursions into the Final Frontier, entrepreneurs and inventors are turning stardust into gold.

Time marches on except in astrophysics. Einstein taught us that time is a coordinate in space, and it's all relative. Learn about the weird physics of our universe that could make time travel possible. Standing in for Lynne Koplitz this week is J. Richard Gott, author of Time Travel in Einstein's Universe.

What’s so funny about space and science? Our season finale features the incomparable comedian Joan Rivers. In this episode, she provides color commentary for a Red Carpet parade of previous show topics, including space tourism, the anniversary of Apollo 11, and the search for alien life (both in space and in Hollywood).

What's so funny about space and science? Our season finale features the incomparable comedian Joan Rivers. In this episode, she provides color commentary for a Red Carpet parade of previous show topics, including space tourism, the anniversary of Apollo 11, and the search for alien life (both in space and in Hollywood).

Special guest Stephen Colbert of Comedy Central's Colbert Report talks about the joys of being a science geek. Brilliant scientific discoveries and cutting edge technology have transformed our world, yet many people are turned off by science. Where has the excitement for science gone, and how can we get it back? Stephen Colbert developed an interest in science at a young age, and now he shares that fascination by inviting scientists to appear on his show The Colbert Report.

Scientists have been searching for aliens in our solar system and beyond, but have not yet found evidence that life exists beyond Earth. SETI, the Search for Extraterrestrial Intelligence, has been scanning the stars for alien radio beacons for 50 years. Radio and TV broadcasts have been leaking from Earth's atmosphere for over a century, and these traveling time capsules could eventually reach a broader audience than ever imagined.