Mark Twain said, “Get your facts first, then you can distort them as you please.” Pseudoscience adheres to this adage, but are their distortions deliberate, the result of scientific ignorance, or due to a deep desire for extraordinary possibilities? In our quest to understand the universe, how can we be sure our conclusions are correct? Human beings have evolved to find meaningful patterns in nature, but sometimes the patterns we see are just figments of our imagination — or perhaps the result of wishful thinking.

This year marks the 400th anniversary of Galileo's use of the first telescope. On this week's show, we reflect on how telescopes have changed our perception of our place in the universe, how small we are in size, space, and time. Our guests include Dava Sobel, author of The Planets, Vatican Astronomer Father Chris Corbally, and astronaut Paul Richards. We also discuss how they help astronomers discover new and interesting aspects of the universe, from Earth-like planets to supernova, from black holes to the Big Bang.

Richard Branson has formed Virgin Galactic and is now taking reservations aboard the maiden voyage of SpaceShipOne. Would you spend the estimated $200,000 for a 45-minute trip into space? Neil and Lynne also discuss the mechanics of sex in space.

"That’s one small step for man, one giant leap for mankind." Neil Armstrong spoke these words after placing his foot down onto lunar soil, and throughout the course of the Apollo program, 11 other astronauts also walked on the Moon. In this show, Neil Armstrong, Buzz Aldrin, and many others share their memories of Apollo, and say what they think should be NASA’s next step in space.

Attempts by scientists and artists to reveal deep truths about the universe may take different forms, but they often end up agreeing with the poet John Keats that “truth is beauty”. Geometry, physics, and the other sciences describe the world we live in, and artists often play with these properties in their own imaginative investigations. From the drawings of Leonardo Da Vinci to high tech computer graphics, Neil and Lynne paint a picture of how science has inspired art through the ages.

Time marches on except in astrophysics. Einstein taught us that time is a coordinate in space, and it's all relative. Learn about the weird physics of our universe that could make time travel possible. Standing in for Lynne Koplitz this week is J. Richard Gott, author of Time Travel in Einstein's Universe.

In a time when our political and cultural views feel more polarized than ever, Tyson provides a much-needed antidote to so much of what divides us, while making a passionate case for the twin chariots of enlightenment—a cosmic perspective and the rationality of science. After thinking deeply about how science sees the world and about Earth as a planet, the human brain has the capacity to reset and recalibrates life’s priorities, shaping the actions we might take in response. No outlook on culture, society, or civilization remains untouched.

Special guest Stephen Colbert of Comedy Central's Colbert Report talks about the joys of being a science geek. Brilliant scientific discoveries and cutting edge technology have transformed our world, yet many people are turned off by science. Where has the excitement for science gone, and how can we get it back? Stephen Colbert developed an interest in science at a young age, and now he shares that fascination by inviting scientists to appear on his show The Colbert Report.

Could you travel to the past and visit Julius Caesar? Could you travel to the year 4000 and see what the future is like? Find out about the possibilities and paradoxes of time travel. Time marches on except in astrophysics. Einstein taught us that time is a coordinate in space, and it’s all relative. Learn about the weird physics of our universe that could make time travel possible. Standing in for Lynne Koplitz this week is J. Richard Gott, III, author of Time Travel in Einstein’s Universe.

Special guest Stephen Colbert of Comedy Central’s Colbert Report talks about the joys of being a science geek. Brilliant scientific discoveries and cutting edge technology have transformed our world, yet many people are turned off by science. Where has the excitement for science gone, and how can we get it back? Stephen Colbert developed an interest in science at a young age, and now he shares that fascination by inviting scientists to appear on his show The Colbert Report.