This year marks the 400th anniversary of Galileo’s use of the first telescope. On this week’s show, we reflect on how telescopes have changed our perception of our place in the universe, how small we are in size, space, and time. Our guests include Dava Sobel, author of The Planets, Vatican Astronomer Father Chris Corbally, and astronaut Paul Richards.

Scientists have been searching for aliens in our solar system and beyond, but have not yet found evidence that life exists beyond Earth. SETI, the Search for Extraterrestrial Intelligence, has been scanning the stars for alien radio beacons for 50 years. Radio and TV broadcasts have been leaking from Earth’s atmosphere for over a century, and these traveling time capsules could eventually reach a broader audience than ever imagined. Neil and Lynne review the methods used to locate aliens and discuss what to do if you’re ever abducted.

Mark Twain said, “Get your facts first, then you can distort them as you please.” Pseudoscience adheres to this adage, but are their distortions deliberate, the result of scientific ignorance, or due to a deep desire for extraordinary possibilities? In our quest to understand the universe, how can we be sure our conclusions are correct? Human beings have evolved to find meaningful patterns in nature, but sometimes the patterns we see are just figments of our imagination — or perhaps the result of wishful thinking.

The Star Trek TV and movie series imagine a bright future for humans in space, one in which we explore alien worlds with the aid of advanced technology. Because the writers tried to include as much realistic science as possible within the fictional framework, the stories have been an inspiration for students, scientists, inventors, and anyone interested in pondering our destiny on Earth and beyond. In this show, Brandon Fibbs reviews a Star Trek movie, and Lawrence Krauss talks about how Star Trek uses science to explore what is possible in our universe.

Attempts by scientists and artists to reveal deep truths about the universe may take different forms, but they often end up agreeing with the poet John Keats that “truth is beauty”. Geometry, physics, and the other sciences describe the world we live in, and artists often play with these properties in their own imaginative investigations. From the drawings of Leonardo Da Vinci to high tech computer graphics, Neil and Lynne paint a picture of how science has inspired art through the ages.

What price do we put on knowledge? How does it profit a man if he learns about the universe, but goes to bed hungry? When the economy takes a downturn, should we still go up into space? NASA missions aren’t cheap - sending astronauts into low Earth orbit or to the Moon, sending robotic spacecraft to explore the planets, and launching telescopes into space can cost millions or even billions of dollars. Lou Friedman, director of the Planetary Society, argues that even when the dollar is dear, the quest to explore our universe is priceless.

Starry, starry nights, stormy and sun-filled days. Long summer days of picnics and ballgames are played out under a vast and gorgeous canvas of astronomical and meteorological curiosities. From the stories of the stars told by the ancients, to a recent mammatus cloud over CitiField in New York, learn about the phenomena in the summer skies that keep us looking up.

What’s so funny about space and science? Our season finale features the incomparable comedian Joan Rivers. In this episode, she provides color commentary for a Red Carpet parade of previous show topics, including space tourism, the anniversary of Apollo 11, and the search for alien life (both in space and in Hollywood).

Could you travel to the past and visit Julius Caesar? Could you travel to the year 4000 and see what the future is like? Find out about the possibilities and paradoxes of time travel. Time marches on except in astrophysics. Einstein taught us that time is a coordinate in space, and it’s all relative. Learn about the weird physics of our universe that could make time travel possible. Standing in for Lynne Koplitz this week is J. Richard Gott, III, author of Time Travel in Einstein’s Universe.

Richard Branson has formed Virgin Galactic and is now taking reservations aboard the maiden voyage of SpaceShipOne. Would you spend the estimated $200,000 for a 45-minute trip into space? Neil and Lynne also discuss the mechanics of sex in space.

Richard Dawkins' brilliant reformulation of the theory of natural selection has the rare distinction of having provoked as much excitement and interest outside the scientific community as within it. His theories have helped change the whole nature of the study of social biology, and have forced thousands to rethink their beliefs about life.

Astrophysicist Neil deGrasse Tyson has attracted one of the world’s largest online followings with his fascinating, widely accessible insights into science and our universe. Now, Tyson invites us to go behind the scenes of his public fame by unveiling his candid correspondence with people across the globe who have sought him out in search of answers. In this hand-picked collection of 100 letters, Tyson draws upon cosmic perspectives to address a vast array of questions about science, faith, philosophy, life, and of course, Pluto.

How the Earth Works takes you on an astonishing journey through time and space. In 48 lectures, you will look at what went into making our planet - from the big bang, to the formation of the solar system, to the subsequent evolution of Earth.

Hilarious, fascinating, and a roller coaster of dizzying, historical what-ifs, Napoleon's Hemorrhoids is a potpourri for serious historians and casual history buffs. In one of Phil Mason's many revelations, you'll learn that Communist jets were two minutes away from opening fire on American planes during the Cuban missile crisis, when they had to turn back as they were running out of fuel. You'll discover that before the Battle of Waterloo, Napoleon's painful hemorrhoids prevented him from mounting his horse to survey the battlefield.

Chemistry and Our Universe: How It All Works is your in-depth introduction to this vital field, taught through 60 engaging half-hour lectures that are suitable for any background or none at all. Covering a year’s worth of introductory general chemistry at the college level, plus intriguing topics that are rarely discussed in the classroom, this amazingly comprehensive course requires nothing more advanced than high-school math. Your guide is Professor Ron B. Davis, Jr., a research chemist and award-winning teacher at Georgetown University.

Welcome to the Universe is a personal guided tour of the cosmos by three of today's leading astrophysicists. Inspired by the enormously popular introductory astronomy course that Neil deGrasse Tyson, Michael A. Strauss, and J. Richard Gott taught together at Princeton, this book covers it all - from planets, stars, and galaxies to black holes, wormholes, and time travel.

From launchpad explosions to a pernicious cricket infestation to the demanding management style of Musk himself, the rise of SpaceX was beset with challenges and far from inevitable. Find out how the startup beat the odds and flew high enough to outpace their rivals... and where they're going next.

How do today's most successful tech companies - Amazon, Google, Facebook, Netflix, Tesla - design, develop, and deploy the products that have earned the love of literally billions of people around the world? Perhaps surprisingly, they do it very differently from the vast majority of tech companies. In Inspired, technology product management thought leader Marty Cagan provides listeners with a master class in how to structure and staff a vibrant and successful product organization and how to discover and deliver technology products that your customers will love.

In The Butchering Art, the historian Lindsey Fitzharris reveals the shocking world of 19th-century surgery on the eve of profound transformation. She conjures up early operating theaters - no place for the squeamish - and surgeons, working before anesthesia, who were lauded for their speed and brute strength. They were baffled by the persistent infections that kept mortality rates stubbornly high. A young, melancholy Quaker surgeon named Joseph Lister would solve the deadly riddle and change the course of history.

In this illuminating audiobook, Tyson and coauthor James Trefil, a renowned physicist and science popularizer, take on the big questions that humanity has been posing for millennia - How did life begin? What is our place in the universe? Are we alone? - and provide answers based on the most current data, observations, and theories.