Libby Miller has always been an unwavering optimist - but when her husband drops a bomb on their marriage the same day a doctor delivers devastating news, she realizes her rose-colored glasses have actually been blinding her. With nothing left to lose, she abandons her life in Chicago for the clear waters and bright beaches of the Caribbean for what might be her last hurrah.

It’s been thirteen years since doctors declared Libby Ross-Velasquez a goner. Yet here she is - cancer-free. So why doesn’t she feel more alive? Sure, Libby’s husband, Shiloh, has been distant. One of their daughters has a serious health condition. And her father’s death hovers over Libby like a rain cloud. Still, this eternal optimist knows she’s the winner of the existential lottery. But when her forced cheer isn’t enough to keep her family from catching her blahs, she decides to fly them all to Vieques. The Puerto Rican island is where she and Shiloh fell in love.

At fifty-three, Maggie Harris has a good marriage and two mostly happy children. Perpetually anxious, she’s also accumulated a list of semi-reasonable fears: falling air conditioners, the IRS, identity theft, skydiving, and airbag recalls. But never once did Maggie worry that her husband of nearly thirty years would leave her.

Laine Francis believes there’s a place for everything—and New York, where her family lives, isn’t her place. But no sooner does the professional organizer’s marriage begin to unravel than her sisters drop another bomb on her: their mother, Sally, may have dementia, and they need Laine to come home.

Wife. Mother. Breadwinner. Penelope Ruiz-Kar is doing it all - and barely keeping it together. Meanwhile, her best friend, Jenny Sweet, appears to be sailing through life. As close as the two women are, Jenny’s passionate marriage, pristine house, and ultra-polite child stand in stark contrast to Penelope’s underemployed husband, Sanjay, their unruly brood, and the daily grind she calls a career.

When struggling novelist James Hernandez meets poet Louisa "Lou" Bell, he's sure he's just found the love of his life. There's just one problem: she's engaged to his oldest friend, Rob. So James toasts their union and swallows his desire. As the years pass, James's dreams always seem just out of reach - he can't finish that novel, can't mend his relationship with his father, can't fully commit to a romantic relationship. He just can't move on.

Overworked and underappreciated, single mom Amy Byler needs a break. So when the guilt-ridden husband who abandoned her shows up and offers to take care of their kids for the summer, she accepts his offer and escapes rural Pennsylvania for New York City. Usually grounded and mild mannered, Amy finally lets her hair down in the city that never sleeps. She discovers a life filled with culture, sophistication, and - with a little encouragement from her friends - a few blind dates.

For Sewanee Chester, being an audiobook narrator is a long way from her old dreams, but the days of being a star on film sets are long behind her. She’s found success and satisfaction from the inside of a sound booth and it allows her to care for her beloved, ailing grandmother. When she arrives in Las Vegas last-minute for a book convention, Sewanee unexpectedly spends a whirlwind night with a charming stranger.

It seems lately that Poppy Lively is invisible to everyone but the IRS. After her accountant absconded with her life savings, newly bankrupt Poppy is on the verge of losing her home when an old flame, now a hotshot producer, gives her a surprising way out: a job in costumes on a Hollywood film set. It’s a bold move to pack her bags, keep secrets from her daughter, and head to Los Angeles, but Poppy's a capable person—how hard can a job in wardrobe be?

When Mackenzie, Sunna, and Maude move into a converted rental house, they are strangers with only one thing in common - important people in their lives have “ghosted” them. Mackenzie’s sister, Sunna’s best friend, and Maude’s fiancé - all gone with no explanation. So when a mangled, near-indecipherable letter arrives in their shared mailbox - hinting at long-awaited answers - each tenant assumes it’s for her.

Eighteen months ago, Autumn Divac's husband went missing. Her desperate search has yielded no answers—she still has no idea where he went or why. After being happily married for twenty years, she can't imagine moving forward without him, but for the sake of their two teenage children, she has to try. Autumn takes her kids home for the summer to the charming beachside town where she was raised. She seeks comfort by working alongside her mother and aunt at their bookshop, only to learn that her daughter is facing a life change and her mother has been hiding a terrible secret.

After three marriages and a lot of living, resilient Billie Slate knows exactly what trouble love can bring. Now she’s reinvented herself as the Heartbreak Bunny, an on-call performance artist who can heal anyone who’s been burned by that four-letter word, LOVE, by hopping about and whisking away sad mementos from their past relationships. Call it magic. Call it peculiar. But her bunny costume is as perfect as her breakup mantra: SNAP OUT OF IT.

Marnie MacGraw wants an ordinary life - a husband, kids, and a minivan in the suburbs. Now that she’s marrying the man of her dreams, she’s sure this is the life she’ll get. Then Marnie meets Blix Holliday, her fiancé’s irascible matchmaking great-aunt who’s dying, and everything changes - just as Blix told her it would. When her marriage ends after two miserable weeks, Marnie is understandably shocked.

Celeste Mason is the Pinterest stay-at-home supermom of other mothers’ nightmares. Despite her all-organic, SunButter-loving, free-range kids, her immaculate home, and her volunteering awards, she still has time to relax with a nice glass of pinot at the end of the day. The only thing that ruins it all is her workaholic, career-obsessed neighbor, who makes no secret of what she thinks of Celeste’s life choices every chance she gets.

Nisha Cantor lives the globetrotting life of the seriously wealthy, until her husband announces a divorce and cuts her off. Nisha is determined to hang onto her glamorous life. But in the meantime, she must scramble to cope--she doesn’t even have the shoes she was, until a moment ago, standing in. That’s because Sam Kemp—in the bleakest point of her life—has accidentally taken Nisha’s gym bag. But Sam hardly has time to worry about a lost gym bag—she’s struggling to keep herself and her family afloat.