On the surface, these seven women are as different as can be - but each has had her share of bad luck, from cheating husbands to sexist colleagues to a legal system that often doesn't do its job. Now, drawn together by tragedy, they're forging a bond that will help them right the wrongs committed against them and discover an inner strength they didn't know they had. The Sisterhood is learning that when bad things happen, you can roll over and play dead...or you can get up fighting...

After years of trying to become pregnant without success, Rachel Dawson and her husband Thomas felt their dreams had finally come true the day they brought home their newly adopted twin babies. Though the lawyer Baron Bell who arranged for the surrogate mother charged a hefty six-figure fee, one glance into the eyes of their precious children told them it was all worth it - until the birth mother reappeared, first demanding more money, then the twins themselves.

Through public triumphs and private sorrows, the men in the Sisters' lives - husbands, friends, colleagues, and lovers - have offered invaluable aid and support. In the process, they've become an informal brotherhood of their own, able to relate to the unique challenges and rewards of life among the vigilantes.

Mateo Castillo is a rising star chef on the Manhattan culinary scene. But just as he’s about to reap the rewards of his skill and hard work by being featured on a major TV cooking competition, Mateo collapses in his restaurant’s kitchen—and regains consciousness in a hospital emergency room. If it weren’t for a security guard finding him in time, Mateo would have bled to death. The cause of his sudden illness is as mysterious as it is worrying, and Mateo and his family undergo a battery of genetic tests. Yet the answers that start to emerge only raise more questions.

Teresa "Toots" Amelia Loudenberry has crammed a great deal of living - not to mention eight much-loved husbands - into her varied and rewarding life. Newly single, Toots is ready to taste life again, and fate has just handed her the perfect opportunity.

At 29, Alison Marshall is ready to find a place to call home. With no family and no ties, she’s drifted from one small Florida town to another since high school, working odd jobs, saving hard, and building a nest egg. Once she finds the right place to settle down, she’ll know. And when she reaches beautiful Palmetto Island, she thinks she may have found it. The small, close-knit island community seems to have everything Alison needs. On a hunch, she contacts the island’s only realtor, and learns that an old beach house is on the market.

Ellie Bowman barely remembers the incident that put her into a coma. When she awoke, filled with unease, all she knew for certain was that her boyfriend, Rick, was missing. She knew she needed to get away from her old life and recover in safety. With the proceeds of a video game she helped develop, Ellie starts over in rural Missouri, working from her cottage and trusting no one except her friend and business partner.

Luna Bodman always looks forward to a new shipment of furniture at the restoration shop. Her brother, Cullen, has a knack for finding discarded pieces with an intriguing history, and Luna likes to sit with each item to see if she can feel any kind of vibrations. Usually, Cullen does his thing while Luna does hers, but the arrival of an old armoire triggers a reaction in Luna that’s impossible to ignore. From the moment Luna wiggles inside the armoire and closes her eyes, she feels an overpowering and disturbing sensation.

With a heart full of dreams, Sallie Coleman leaves Texas and heads west determined to get as far from the squalor of her dirt poor beginnings. With its shifting sands, smoky saloons, and bingo palaces, Las Vegas seems like a paradise. A paradise where an extraordinary twist of fate makes Sallie the most powerful businesswoman in Nevada.

At Ridgewood High, Amy, Frankie, Rachael, and Nina formed a deep bond. Now, 15 years after leaving school behind, they’re back for a reunion, laughing, reminiscing, and chatting how much has changed - and how much hasn’t. But Frankie has an idea to help solve that: a singles cruise for the holidays.

From her silver Mercedes to her designer kitchen, Molly's life is gleaming and beautiful - at least on the surface. Married to Tanner, a top cosmetic dentist, she has a wonderful daughter finishing high school and twin stepsons from Tanner's first marriage. No one in her exclusive neighborhood in Goldenhills, Massachusetts, knows what living with the demanding Tanner is really like. They know even less about the life she left behind in Florida almost two decades ago.

Tessa Jamison couldn't have imagined anything worse than losing her beloved twin girls and husband - until she was convicted of their murder. For 10 years, she has counted off the days in Florida's Correctional Center for Women, fully expecting to die behind bars. Fighting to prove her innocence holds little appeal now that her family's gone. But on one extraordinary day, her lawyers announce that Tessa's conviction has been overturned due to a technicality, and she's released on bail to await a new trial. Hounded by the press, Tessa retreats to the small tropical island owned by her late husband's pharmaceutical company. There, she begins to gather knowledge about others in similar situations to her own...people who have lost their families in horrific ways, only to see the perpetrators walk away unpunished. For the first time since her nightmare began, Tessa feels a sense of purpose.

When Carol Ann “CJ” Jansen lost her beloved older brother, Kick, in a boating accident, she came adrift. Kick had taken on the role of caring for his little sister after their parents were killed in a car crash. Inheriting half his fortune has left CJ financially secure - yet needing a purpose. As administrative assistant to powerful congressman Snapper Lewis, she’s immersed herself in the exciting and often tumultuous world of politics. But suddenly, the career that anchors her life is threatened.

For generations, the Windsors have lived on the family's grand estate in Crestwood, South Carolina, as intertwined with local life as sweet tea and pecan pie. Now, on the anniversary of her daughter Emily's death, Sarabess Windsor believes she may be the last to carry the family name - unless she can find her second daughter, Trinity, who disappeared 15 years ago.

Back in college, Jane Lewis would have given anything to be like homecoming queen Connie Bryan. Instead she was just Plain Jane - overweight, frumpy, and painfully shy. That was then. Today, a lovely and confident Dr. Jane Lewis has a thriving psychotherapy practice, her own radio talk show, a beautiful old Louisiana mansion, and her affectionate, nutty dog, Olive, to keep her company. The only thing missing is someone to share her life.