From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.

Set in the mountains of southern Appalachia, Demon Copperhead is the story of a boy born to a teenaged single mother in a single-wide trailer, with no assets beyond his dead father’s good looks and copper-colored hair, a caustic wit, and a fierce talent for survival. Relayed in his own unsparing voice, Demon braves the modern perils of foster care, child labor, derelict schools, athletic success, addiction, disastrous loves, and crushing losses.

For more than two hundred years, disturbances of the mind—the sorts of things that were once called "madness"—have been studied and treated by the medical profession. Mental illness, some insist, is a disease like any other, whose origins can be identified and from which one can be cured. But is this true? In this masterful account of America's quest to understand and treat everything from anxiety to psychosis, one of the most provocative thinkers writing about psychiatry today sheds light on its tumultuous past.

A diabetic woman awakens from a coma having forgotten the last 10 years of her life. A Haitian immigrant has nightmares that begin bleeding into his waking hours. A retired teacher loses the use of her right hand due to pain of no known origin. Noga Arikha began studying these patients and their confounding symptoms in order to explore how our physical experiences inform our identities. Soon after she initiated her work, the question took on unexpected urgency, as Arikha’s own mother began to show signs of Alzheimer’s disease.

In Life Finds a Way, biologist Andreas Wagner reveals the deep symmetry between innovation in biological evolution and human cultural creativity. Rarely is either a linear climb to perfection - instead, "progress" is typically marked by a sequence of peaks, plateaus, and pitfalls. For instance, in Picasso's 40-some iterations of Guernica, we see the same combination of small steps, incessant reshuffling, and large, almost reckless, leaps that characterize the way evolution transformed a dinosaur's grasping claw into a condor's soaring wing.

Wouldn’t you like to live longer? And better? In this operating manual for longevity, Dr. Peter Attia draws on the latest science to deliver innovative nutritional interventions, techniques for optimizing exercise and sleep, and tools for addressing emotional and mental health.

Many famed music producers are known for a particular sound that has its day. Rick Rubin is known for something else: creating a space where artists of all different genres and traditions can home in on who they really are and what they really offer. He has made a practice of helping people transcend their self-imposed expectations in order to reconnect with a state of innocence from which the surprising becomes inevitable. Over the years, he has learned that being an artist isn’t about your specific output, it’s about your relationship to the world.

This magnificent novel - which secured for its author the 1955 Nobel Prize in Literature - is now available to contemporary American audiences. Although it is set in the early 20th century, it recalls both Iceland's medieval epics and such classics as Sigrid Undset's Kristin Lavransdatter. And if Bjartur of Summerhouses, the book's protagonist, is an ordinary sheep farmer, his flinty determination to achieve independence is genuinely heroic and, at the same time, terrifying and bleakly comic.

How does the brain—a three-pound wrinkly mass—give rise to intelligence and conscious experience? Was Freud right that we are all plagued by forbidden sexual desires? What is the function of emotions such as disgust, gratitude, and shame? Renowned psychologist Paul Bloom answers these questions and many more in Psych, his riveting new book about the science of the mind.

Few journalists working today have covered Donald Trump more extensively than Maggie Haberman. And few understand him and his motivations better. Now, demonstrating her majestic command of this story, Haberman reveals in full the depth of her understanding of the 45th president himself, and of what the Trump phenomenon means.

We feel, therefore we are. Conscious sensations ground our sense of self. They are crucial to our idea of ourselves as psychic beings: present, existent, and mattering. But is it only humans who feel this way? Do other animals? Will future machines? Weaving together intellectual adventure and cutting-edge science, Nicholas Humphrey describes in Sentience his quest for answers: from his discovery of blindsight in monkeys and his pioneering work on social intelligence to breakthroughs in the philosophy of mind.

This pioneering account sets out to understand the structure of the human brain - the place where mind meets matter. Until recently, the left hemisphere of our brain has been seen as the "rational" side, the superior partner to the right. But is this distinction true? Drawing on a vast body of experimental research, Iain McGilchrist argues while our left brain makes for a wonderful servant, it is a very poor master.

The millions of people around the world who loved What If? still have questions, and those questions are getting stranger. Thank goodness xkcd creator Randall Munroe is here to help. Planning to ride a fire pole from the Moon back to Earth? The hardest part is sticking the landing. Hoping to cool the atmosphere by opening everyone’s freezer door at the same time? Maybe it’s time for a brief introduction to thermodynamics. Want to know what would happen if you rode a helicopter blade, made a lava lamp out of lava, or jumped on an erupting geyser? Okay, if you insist.

Dylan, who began working on the book in 2010, offers his insight into the nature of popular music. He writes over sixty essays focusing on songs by other artists, spanning from Stephen Foster to Elvis Costello, and in between ranging from Hank Williams to Nina Simone. He analyzes what he calls the trap of easy rhymes, breaks down how the addition of a single syllable can diminish a song, and even explains how bluegrass relates to heavy metal. These essays are written in Dylan’s unique prose. And while ostensibly about music, they are really meditations on the human condition.

For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight-how the same simple chemistry gives rise to life and causes our demise.

Richard Dawkins' brilliant reformulation of the theory of natural selection has the rare distinction of having provoked as much excitement and interest outside the scientific community as within it. His theories have helped change the whole nature of the study of social biology, and have forced thousands to rethink their beliefs about life.

Astrophysicist Neil deGrasse Tyson has attracted one of the world’s largest online followings with his fascinating, widely accessible insights into science and our universe. Now, Tyson invites us to go behind the scenes of his public fame by unveiling his candid correspondence with people across the globe who have sought him out in search of answers. In this hand-picked collection of 100 letters, Tyson draws upon cosmic perspectives to address a vast array of questions about science, faith, philosophy, life, and of course, Pluto.

How the Earth Works takes you on an astonishing journey through time and space. In 48 lectures, you will look at what went into making our planet - from the big bang, to the formation of the solar system, to the subsequent evolution of Earth.

Hilarious, fascinating, and a roller coaster of dizzying, historical what-ifs, Napoleon's Hemorrhoids is a potpourri for serious historians and casual history buffs. In one of Phil Mason's many revelations, you'll learn that Communist jets were two minutes away from opening fire on American planes during the Cuban missile crisis, when they had to turn back as they were running out of fuel. You'll discover that before the Battle of Waterloo, Napoleon's painful hemorrhoids prevented him from mounting his horse to survey the battlefield.

Chemistry and Our Universe: How It All Works is your in-depth introduction to this vital field, taught through 60 engaging half-hour lectures that are suitable for any background or none at all. Covering a year’s worth of introductory general chemistry at the college level, plus intriguing topics that are rarely discussed in the classroom, this amazingly comprehensive course requires nothing more advanced than high-school math. Your guide is Professor Ron B. Davis, Jr., a research chemist and award-winning teacher at Georgetown University.

Welcome to the Universe is a personal guided tour of the cosmos by three of today's leading astrophysicists. Inspired by the enormously popular introductory astronomy course that Neil deGrasse Tyson, Michael A. Strauss, and J. Richard Gott taught together at Princeton, this book covers it all - from planets, stars, and galaxies to black holes, wormholes, and time travel.

From launchpad explosions to a pernicious cricket infestation to the demanding management style of Musk himself, the rise of SpaceX was beset with challenges and far from inevitable. Find out how the startup beat the odds and flew high enough to outpace their rivals... and where they're going next.

How do today's most successful tech companies - Amazon, Google, Facebook, Netflix, Tesla - design, develop, and deploy the products that have earned the love of literally billions of people around the world? Perhaps surprisingly, they do it very differently from the vast majority of tech companies. In Inspired, technology product management thought leader Marty Cagan provides listeners with a master class in how to structure and staff a vibrant and successful product organization and how to discover and deliver technology products that your customers will love.

In The Butchering Art, the historian Lindsey Fitzharris reveals the shocking world of 19th-century surgery on the eve of profound transformation. She conjures up early operating theaters - no place for the squeamish - and surgeons, working before anesthesia, who were lauded for their speed and brute strength. They were baffled by the persistent infections that kept mortality rates stubbornly high. A young, melancholy Quaker surgeon named Joseph Lister would solve the deadly riddle and change the course of history.

In this illuminating audiobook, Tyson and coauthor James Trefil, a renowned physicist and science popularizer, take on the big questions that humanity has been posing for millennia - How did life begin? What is our place in the universe? Are we alone? - and provide answers based on the most current data, observations, and theories.