• #31 - Measuring sleep remotely - Soumya Dash - Sleepiz
    Sep 15 2024
    Sleep is the resting state that nature has chosen for us by default. Long overlooked or even neglected, it is one of the keys to good health, alongside nutrition, physical exercise, and mental and emotional health. Moreover, it is an excellent indicator of our overall health: when our sleep is disturbed, it usually means at least one of these four components is affected. It thus seems essential to be able to measure the quality of our sleep while minimizing the interaction or invasiveness of the measurement method with our body. And that is precisely the promise of Soumya Dash and his company Sleepiz! Based on radar technology, this Swiss startup has developed a compact device to place on a bedside table, capable of remotely clinically measuring sleep and detecting potential disorders such as sleep apnea or insomnia. No electroencephalogram to wear on the head, no pulse oximeter on the finger, nor any wearable around the wrist: everything is measured from the bedside table and without any direct interaction with the subject measured. In this surprising episode, we dive into the fascinating world of sleep, a realm with many secrets still to be uncovered! Soumya shares with us insights into the technology his team has developed, the difference between consumer-grade and medical-grade sleep monitors, and a glimpse into the future of healthcare in this field! Timeline: 00:02:21 - How Soumya came across sleep monitoring and why it matters 00:12:45 - How the Sleepiz device monitors sleep 00:18:20 - Relevant use cases and target indications of sleep disorders 00:22:35 - Differences between consumer-grade vs. medical-grade sleep monitors 00:25:35 - B2C and B2B business models 00:37:43 - Past milestones and challenges ahead What we also talked about with Soumya: ETH Zürich ISO 13485 norm Class IIa medical device 510(k) FDA clearance Chronic Obstructive Pulmonary Disease (COPD) Oura Ring WHOOP IDUN Technologies SmartCardia As mentioned by Soumya during the episode, you can learn more about sleep and the current state of research in the book Why We Sleep: Unlocking the Power of Sleep and Dreams by Matthew Walker. You will find more information about Sleepiz on their website and you can follow their activities on LinkedIn. If you want to get in touch with Soumya, you can do so via LinkedIn. If you want to give me feedback on the episode or suggest potential guests, contact me over LinkedIn or via email! And if you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms! 🙏 There’s now a bi-monthly newsletter around the podcast where you will be informed of the latest episodes and kept posted on the latest medical tech progress, subscribe here! Lastly, don’t forget to follow our activities on LinkedIn and our website!
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    55 mins
  • [EXTRACT] - Soumya Dash on consumer versus medical grade products
    Sep 15 2024
    To discover the whole episode type "#31 - Measuring sleep remotely - Soumya Dash - Sleepiz" on your streaming platform.
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    3 mins
  • #30 - Building the Shopify of digital health - Dan Vahdat - Huma
    Sep 8 2024
    Dan Vahdat is an emblematic figure and entrepreneur in healthtech. A visionary we could say, having anticipated the problem of point solutions in the industry, while predicting the essential role smartphones would have in empowering patients to take control of their health. The company he founded after pausing his PhD, Huma, has pioneered the field of digital health and remote patient monitoring, having been one of the first to successfully deliver digital disease management programs across multiple conditions. The first to receive regulatory clearance in Europe (IIb) and the US (II) for its configurable disease management platform. As the firm is nearing the status of “unicorn” in its 13th year and approaching profitability, it’s never been so close to realizing Dan’s vision: augmenting the capacity of health systems at scale while enabling true proactive and predictive care. Huma’s list of successes is immense: more than 3000 hospitals and clinics supported, 27 million patients served, Winner of the 2022 Prix Galien award for digital health, and the list goes on… But the Founder’s ambition does not stop there. In this fascinating episode, Dan explains Huma’s journey toward becoming the “Shopify” of digital health, or in other words, the central infrastructure on which other digital health companies can successfully build disease management programs, more efficiently and at less cost. In the challenging business of digital health, Dan shares his reflections on what enabled Huma to succeed where many other companies failed. He explains the approach they took when it comes to fostering patient engagement, addressing healthcare professionals’ needs, and being relentless about building robust clinical and economic evidence. An inside look into one of the most innovative firms in digital health, and the future of this industry! Timeline: 00:03:04 - Dan’s background from dropping out of his PhD to founding Huma 00:06:16 - Huma’s starting point focusing on rare diseases 00:08:09 - The Huma platform and how it is changing how we deliver care 00:10:56 - Creating the Shopify for digital health 00:17:25 - How Huma is improving running decentralized clinical trials 00:21:53 - The importance of UX and evidence generation 00:24:42 - Making engaging digital health solutions 00:28:14 - What excites Dan for digital health’s future 00:34:02 - Dan’s reflections on his journey from PhD dropout to Huma’s CEO 00:37:40 - Maximizing operational efficiency in a healthtech startup What we also talked about with Dan: Second Opinion Peterson Technology Health Institute Elon Musk by Walter Isaacson 23andme Vertex Pharmaceuticals We cited with Dan some of the past episodes of the series: #21 - Transforming hypertension care with a bracelet - Jay Shah - Aktiia #23 - Disrupting the smart wearables industry - Leo Grünstein - Spiden This episode was made possible with the support of HLTH Europe! As mentioned by Dan during the episode, you can join the waitlist for the Huma Cloud Platform here. You will find on their website more information about their latest news and research. You can follow Huma’s activities on LinkedIn and X, and get in touch with Dan via LinkedIn. If you want to give me feedback on the episode or suggest potential guests, contact me over LinkedIn or via email! And if you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms! 🙏 There’s now a bi-monthly newsletter around the podcast where you will be informed of the latest episodes and kept posted on the latest medical tech progress, subscribe here! Lastly, don’t forget to follow our activities on LinkedIn and our website!
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    49 mins
  • [EXTRACT] - Dan Vahdat on enabling digital health programs at scale
    Sep 8 2024
    To discover the whole episode type "#30 - Building the Shopify of digital health - Dan Vahdat - Huma" on your streaming platform.
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    3 mins
  • #29 - Fighting atherosclerosis with cavitation - Scott Nelson - FastWave Medical
    Sep 1 2024
    Scott Nelson is a true authority in the Medtech field. A serial entrepreneur, investor, and early podcaster with Medsider, he currently leads FastWave Medical, a startup developing a method to combat atherosclerosis, specifically the rigid plaques formed by significant calcium deposits in blood vessels. The principle behind this technology is cavitation, which involves the formation, growth, and implosive collapse of bubbles in a liquid medium. When sonic pressure waves are transmitted through a balloon catheter filled with liquid, they cause rapid pressure changes in the surrounding fluid. These pressure changes result in the formation of bubbles within the fluid rapidly expanding and collapsing violently. The shock waves created by these bubbles' explosion weaken solid nearby structures while leaving soft tissues intact. The idea is to break down calcium deposits without affecting the blood vessels, which regain flexibility. It thereby reduces the risk of obstruction or increased local blood pressure, and facilitates the placement of a stent or the expansion of the vessel with another balloon catheter. The method, called intravascular lithotripsy (IVL), is already used by interventional cardiologists. Still, much work remains to make it easier to use, more cost-efficient, and ultimately democratize further this practice, whose clinical benefits have already been proven. This is at the core of FastWave Medical’s mission. Given the rapid development of the company (having raised $12 million in just six months after its incorporation in 2021) and its progress in clinical validation stages, there is no doubt that it is poised to disrupt and expand an emerging market where only a few firms operate. In this episode, we talk with Scott about medtech entrepreneurship, being a visionary in a highly regulated industry, and the importance of sharing experience and expertise to progress daily in one’s healthcare career. An episode with one of the leading voices in the medtech scene, offering a glimpse into the future of cardiac surgery! Timeline: 00:02:23 - Scott’s background in Medtech 00:07:34 - FastWave Medical’s mission in cardiac surgery 00:10:35 - Working principle of IVL 00:20:23 - Adoption in clinical practice 00:22:30 - What FastWave Medical does differently than its competitors 00:26:33 - Driving the costs of the surgical intervention down 00:27:44 - Towards additional medical indications for IVL 00:30:58 - Starting Medsider and podcasting before the iPhone What we also talked about with Scott: Stents Balloon catheters Atherectomy Joovv Shockwave Medical CTO Plus Cardiovascular Research Foundation Miguel Montero-Baker Venkatesh Ramaiah As mentioned by Scott during the episode, we recommend looking at the IVL Science page on FastWave Medical’s website as well as The Catalyst Blog curated by Shockwave Medical, to learn more about IVL and its latest progress. If you are yourself in MedTech entrepreneurship, do check out Medsider and the numerous resources and insights it offers, including interviews from other Founders and CEOs, a newsletter, and playbooks. You can also listen to the Medsider Podcast on all streaming platforms! You can contact Scott via email and follow his activities on LinkedIn. If you want to give me feedback on the episode or suggest potential guests, contact me over LinkedIn or via email! And if you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms! ⭐️ There’s now a bi-monthly newsletter around the podcast where you will be informed of the latest episodes and kept posted on the latest medical tech progress, subscribe here! Lastly, don’t forget to follow our activities on LinkedIn and our website!
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    47 mins
  • [EXTRACT] - Scott Nelson on proposing new tools for cardiac surgery
    Sep 1 2024
    To discover the whole episode type "#29 - Fighting atherosclerosis with cavitation - Scott Nelson - FastWave Medical" on your streaming platform.
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    4 mins
  • #28 - Modeling embryos to understand early life - Jacob Hanna - Weizmann Institute of Science
    May 7 2024
    Because of ethical and medical challenges, early human embryo development remains “a black box” to us, as Prof. Jacob Hanna himself puts it. Despite all the progress made in medicine over the past decades, there is still a whole lot to learn about the causes of miscarriages, infertility, or early developmental defects. In 2023, Jacob’s group from the Weizmann Institute of Science published a pivotal paper in Nature that redefines how we study developmental biology, with the potential to accelerate our understanding of early human life. Their achievement? The creation of the first synthetic embryo model closely resembling a day-14 fetus, obtained “ex utero” without gametes and outside a womb. A human embryo model derived from “naive” stem cells in the lab, which can be obtained from “adult” cells that make up our body (like skin cells for instance). A technology that could generate embryo models of ourselves based on a simple cell sample. This work had an unprecedented impact on the scientific community and the general public, being named by TIME Magazine as one of the 100 best inventions of 2023. A breakthrough that raises important ethical, technical, and legal questions. I had the honor of meeting Jacob for this episode of Impulse, with whom we discuss the functioning of this fascinating technology, its potential medical applications in the future, and the key societal questions it raises. A conversation where we dive into the magic of human development, with a stellar scientist and advocate for responsible scientific research! Timeline: (00:02:58) - Jacob’s journey from his medical practice to studying developmental biology (00:06:09) - Why we know so little about early human development (00:08:45) - Jacob’s lab breakthrough in modeling human embryos (00:16:20) - Reprogramming cells to their “naïve” state (00:18:09) - Dealing with your research being put under the spotlight (00:20:02) - The “recipe” to create human embryo models without gametes and outside a womb (00:27:22) - Ethical considerations and how far we can go with this technology (00:35:15) - Potential medical applications for the future (00:38:05) - Jacob’s role as an adviser to the startup Renewal Bio What we also talked about with Jacob: Prof. Shinya Yamanaka (2012 Nobel Prize in Physiology or Medicine with Prof. John Gurdon) Induced pluripotent stem cells (iPSCs) Embryonic stem cells International Society for Stem Cell Research (ISSCR) Taledomide We cited with Jacob some of the past episodes of the series:: #23 - Disrupting the smart wearables industry - Leo Grünstein - Spiden As mentioned by Jacob during the episode, we recommend the book “The Master Builder” by Prof. Alfonso Martinez Arias, challenging the traditional thinking where cells (and not DNA) may hold the key to understanding life’s past and present. Feel free to follow the Weizmann Institute of Science on LinkedIn. You can contact Jacob via email and follow his activities on LinkedIn, X, and Facebook! If you want to give me feedback on the episode or suggest potential guests, contact me over LinkedIn or via email! And if you liked the episode, please share it, subscribe to the podcast, and leave a 5-star review on streaming platforms! 🙏 There’s now a bi-monthly newsletter around the podcast where you will be informed of the latest episodes and kept posted on the latest medical tech progress, subscribe here! Lastly, don’t forget to follow our activities on LinkedIn and our website!
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    48 mins
  • [EXTRACT] - Jacob Hanna on the ethical implications of human embryo models
    May 7 2024
    To discover the whole episode type "#28 - Modeling embryos to understand early life - Jacob Hanna - Weizmann Institute of Science" on your streaming platform.
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    4 mins