In this episode, Dr. Adam Rinde welcomes back microbiologist and PolyBio Research Foundation co-founder Dr. Amy Proal. Together, they unravel a framework for understanding chronic illnesses through the lens of persistent infections and their impact on mitochondria, immunity, and neurological health.

Dr. Proal shares cutting-edge research linking pathogens like herpesviruses, cytomegalovirus, Epstein-Barr, and even latent parasites to conditions like Alzheimer’s, long COVID, chronic fatigue syndrome, POTS, and more. Discover how stealth microbes can disrupt the vagus nerve, hijack mitochondrial energy systems, and weaken immune responses, setting the stage for a cascade of chronic dysfunctions.

The conversation dives deep into the role of immune modulation, including promising findings around low-dose rapamycin and its potential to restore immune signaling and combat viral persistence. They also explore diet, metabolic interventions, and new clinical trials shaping the future of treatment.

Whether you’re a patient, practitioner, or curious mind, this episode offers profound insight into the evolving science of chronic illness and hope for emerging therapies. 🌱

🕰 TIMESTAMPS

00:00 – Intro + Sponsor Healthgevity⁠⁠ (use code ONETHING for 10% off)
01:04 – Meet Dr. Amy Proal
03:14 – Chronic infection’s hidden role in disease
07:09 – Alzheimer’s and pathogens in the brain
13:16 – Viral persistence and the vagus nerve
15:37 – Spectrum of microbes linked to illness
18:51 – PolyBio’s research focus: long COVID & mitochondria
20:11 – How viruses hijack mitochondria
25:46 – Immune dysregulation, interferons & mTOR
27:41 – The promise of low-dose rapamycin
32:32 – Rapamycin vs. Metformin vs. Keto
36:25 – Chronic infection & metabolic downshift
39:31 – Early observations from rapamycin use
43:13 – Natural killer cells & new immunotherapy
46:15 – Final thoughts + how to support PolyBio

🎧 Follow the One Thing Podcast for more deep dives into root-cause medicine and emerging research.
📢 Learn more at polybio.org and support their transformative work.

You can support the podcast through affiliate sponsors like ⁠Healthgevity⁠ (use code ONETHING for 10% off)Full Show notes can be found at https://www.onethingpod.com/episode-117-the-hidden-microbial-drivers-of-chronic-illness-with-dr-amy-proal/

This week on The One Thing Podcast, host Dr. Adam Rinde welcomes back renowned rheumatologist Dr. Aly Cohen to dive deep into her groundbreaking new book, "Detoxify" (releasing May 2025!).

Forget extreme deprivation and unsustainable measures. Dr. Cohen shares her balanced, practical, and science-backed approach to navigating the environmental toxins that challenge our bodies daily. Learn how to reduce your body's burden, support your immune system, and gain peace of mind by focusing not just on avoiding toxins, but also on adding supportive nutrients and lifestyle habits that fit into real life. This is essential listening for anyone looking to optimize their health in the modern world!

Tune in to discover:

• • (00:00) How you can support the podcast through affiliate sponsors like Healthgevity (use code ONETHING for 10% off).

  • (02:34) An introduction to Dr. Cohen's new book, "Detoxify," and how it complements her previous work, offering a more user-friendly framework.

  • (04:18) Dr. Cohen’s "Four A’s" framework (Assess, Avoid/Swap, Add, and Allow) for navigating environmental health simply and effectively.

  • (06:59) Why our bodies, unexposed to such a high load of synthetic chemicals throughout evolution, yearn for removal and support.

  • (09:47) The accessible and motivating 21-day plan in "Detoxify" designed to help you get started without overwhelm.

  • (11:24) Who is most susceptible to immune toxicity and can benefit most from this approach, including those with and without diagnosed autoimmune conditions.

  • (14:32) Dr. Cohen explains autoimmunity in simple terms – what’s happening when your immune system feels "supercharged" against itself.

  • (18:11) The mechanisms: How toxins impact the immune system and why lowering the overall chemical load is key.

  • (22:52) Shifting from fear to resilience: Making sustainable choices and building a healthier internal environment.

  • (25:03) Practical, high-yield changes: The surprising benefits and accessibility of USDA organic frozen foods.

  • (26:34) Dr. Cohen’s sensible approach to assessment – utilizing questionnaires and strategic, insurance-covered blood tests over expensive, broad panels.

  • (39:28) The "Three S's" for natural detoxification and well-being: Sleep, Stress management, and Sweat (and how our bodies are designed for them!).

  • (44:06) Powerhouse foods for detoxification: Why cruciferous vegetables are standouts and how food truly can be medicine.

  • (47:51) Maintaining hope for future generations: Dr. Cohen’s perspective on educating children about environmental health.

  • (53:54) Where to find Dr. Aly Cohen online, including her Smart Human Podcast and resources at smarthuman.com.

Learn more about Dr. Cohen at The Smart Human

See her new book Detoxify: https://www.amazon.com/Detoxify-Everyday-Toxins-Harming-Against/dp/1668033534.

If you found this episode valuable, please share it with friends, family, and anyone you think might benefit from this essential information!

• #Detoxify #DrAlyCohen #TheOneThingPodcast #EnvironmentalHealth

In this episode, Dr. Adam Rinde sits down with integrative medicine specialist Dr. Carla Kuon from University of California San Francisco (UCSF) to explore the latest insights into long COVID, chronic fatigue syndrome, and post-viral illnesses. Dr. Kuon shares powerful breakthroughs from her clinical work and research—especially around mitochondrial health and how overlooked deficiencies in riboflavin (B2) and iron (ferritin) can disrupt the body's energy systems.

You’ll learn how chronic inflammation, nervous system dysregulation, and “bad programming” in the brain are key components of these conditions—and how holistic strategies like nutrient therapy, mindfulness, and vagus nerve stimulation are helping patients recover.

Whether you’re a patient, provider, or just curious about the future of functional medicine, this conversation is full of takeaways and hope. 💛

00:00 – Intro & sponsor01:04 – Meet Dr. Kuon: Long COVID, CFS & fibromyalgia04:11 – Microclots, brain rewiring & dysautonomia07:46 – The 4 fatigue buckets: updated understanding10:06 – Cell danger response & the stuck nervous system14:40 – Riboflavin: the overlooked vitamin for mitochondria19:41 – Iron, ferritin, and why levels matter more than you think23:44 – Digging deeper into nutrient absorption issues27:00 – Kreb cycle breakdown: how energy is made30:08 – Iron infusions, glutathione, and absorption challenges35:15 – UCSF research: viral persistence & new drug trials38:10 – Long COVID & the HIV research legacy41:37 – Mindfulness saved my medical career44:09 – Vagal nerve tools: gadgets, breath, and acupuncture45:17 – Final thoughts: There is hope

📚 Mentioned in this episode:

• ⁠⁠⁠The LONG COVID Solution: A holistic, integrative approach to post viral recovery.⁠⁠

• UCSF Optimal Clinic

• MBSR (Mindfulness-Based Stress Reduction)

• GammaCore & vagus nerve stimulation tools

🔗 Subscribe & share with someone who needs this.

#LongCovid #ChronicFatigue #FunctionalMedicine #Mitochondria #PostViralRecovery #OneThingPodcast #DrCarlaKuon

👇 Links:

Dr. Kuon's website:

Dr. Kuon's book ⁠⁠The LONG COVID Solution: A holistic, integrative approach to post viral recovery.⁠

Our Affiliate Sponsor:

Healthgevity has revolutionized the wellness industry by providing the finest quality and most effective nutritional products for the ultimate health-span. Working in tandem with doctors, patients, and scientific researchers, ⁠Healthgevity⁠ is at the forefront of nutritional technology and personalized wellness. Enter Code: OneThing on purchase for 10% discount #LongCovid #ChronicFatigue #MitochondriaHealth #FunctionalMedicine #IntegrativeHealing #OneThingPodcast #DrCarlaKuon #PostViralRecovery

In this episode of The One Thing Podcast, Dr. Adam Rinde and Dr. Paul Anderson discuss a powerful concept shaping chronic illness care: the Cell Danger Response (CDR).

If you or someone you know is dealing with persistent fatigue, inflammation, long COVID, or autoimmune challenges, this discussion offers deep insights into what may be happening at the cellular level—and why traditional approaches often fall short.

Dr. Anderson explains the phases of the CDR, how it affects mitochondrial function, and why some patients feel worse when they start treatment. They also explore supportive therapies, the importance of gentle intervention, and how to approach healing sustainably and individually.

Key topics:

• What is the Cell Danger Response?

• How CDR connects to chronic illness, PTSD, and autism

• Common treatment pitfalls and how to avoid them

• When to support vs. when to detox

• The future of mitochondrial medicine and personalized healing

Whether you're a practitioner or navigating your own health journey, this episode provides clarity, compassion, and actionable takeaways.

🎙️ Hosted by Dr. Adam Rinde
🧠 Guest: Dr. Paul Anderson

Connect & Learn More
📚 Dr. Anderson’s work: https://www.consultdranderson.com/about/
💬 Share this episode with someone who needs it!
🌐 www.onethingpodcast.com

In this episode of The One Thing Podcast, host Adam Rinde interviews neurologist Dr. Sui Wong to discuss a revolutionary approach to migraine management. Migraines are often treated reactively, but what if we could build resilience against them from the ground up? Dr. Wong shares insights into how lifestyle interventions, brain resilience, and nervous system regulation can play a crucial role in reducing migraine attacks.

They also dive into:
🧠 The science behind migraines and why they’re more than just headaches
💡 How stress and lifestyle factors influence migraine frequency
🌙 The importance of sleep, nutrition, and physical activity in brain health
🔥 Dr. Wong’s unique "boiling pot" analogy for managing migraine triggers
📚 Her latest books on brain health, mindfulness, and metabolic health

If you or someone you know struggles with migraines, this episode is packed with actionable strategies and cutting-edge research. Don't forget to subscribe and hit the bell for more insightful conversations!

🔗 Links & Resources:
📖 Dr. Sui Wong’s Books: drsuiwongmd.com
📩 Sign up for Dr. Wong’s Thursday Tips Newsletter:
🌐 Visual Snow Initiative: [Link]

Our Affiliate Sponsors:

Sapien CE Today, 75% of Healthcare Professionals listen to podcasts for educational learning. Turn Podcasts into reflective learning opportunities with SapienCE powered by Learner+. Check out … This link… to learn more

Healthgevity has revolutionized the wellness industry by providing the finest quality and most effective nutritional products for the ultimate health-span. Working in tandem with doctors, patients, and scientific researchers, Healthgevity is at the forefront of nutritional technology and personalized wellness. Enter Code: OneThing on purchase for 10% discount

⏳ TIMESTAMPS:
00:00 – Introduction & Sponsor Message
01:03 – Why migraines need a new approach
03:30 – Dr. Sui Wong’s journey in neurology & lifestyle medicine
11:00 – Quality of life and chronic conditions
18:00 – What we now understand about migraines
25:00 – The role of sleep, nutrition, and physical activity in brain health
33:00 – How stress & the autonomic nervous system impact migraines
40:00 – Strengthening resilience & preventing migraine attacks
46:00 – Dr. Wong’s books and resources
50:00 – Supporting Visual Snow Research

💬 What was your biggest takeaway from this episode? Drop a comment below!

#MigraineRelief #BrainHealth #DrSuiWong #TheOneThingPodcast #HolisticHealth #Neurology

Parkinson's and gut health: The connection you need to understand! Uncover practical steps you can take today to support a healthier gut environment and improve overall well-being for both patient and caregiver

In this episode of The One Thing Podcast, Dr. Adam Rinde dives deep into the fascinating world of the microbiome with Martha Carlin, a citizen scientist, entrepreneur, and microbiome expert. After her husband's Parkinson’s diagnosis, Martha took a radical approach—teaching herself chemistry, microbiology, and systems biology to uncover the connection between gut health and neurological conditions. Martha is the founder of **The Biocollective** and **BiotiQuest** @biotiquest4511 , and her research has led to groundbreaking discoveries in gut health, probiotics, and disease prevention. In this episode, she shares insights on how the microbiome impacts brain health, digestion, and overall well-being, including how gut bacteria might be a key player in Parkinson’s disease. 🔬

**Key Topics Covered:**

✅ Martha’s journey from business consultant to microbiome researcher

✅ The link between **gut health and Parkinson’s** disease ✅ The role of **probiotics, prebiotics, postbiotics, and phages**

✅ How **gut bacteria influence dopamine levels** and brain function

✅ The surprising impact of **oral health and gut permeability**

✅ How a **simple dietary hack** helped her husband sleep better

✅ The latest in **probiotic research & the future of gut health**

📌 **TIMESTAMPS:**

00:00 - Intro to The One Thing Podcast 🎙️

01:30 - Meet **Martha Carlin** & her journey into microbiome research

06:45 - Discovering the **gut-brain connection** & Parkinson’s

12:20 - The **microbiome’s role in digestion & disease** 18:10 - How **probiotics can reshape gut health** 🦠

25:40 - The link between **oral health & neurodegenerative disease**

31:15 - **Phages, prebiotics, and postbiotics** – what’s the difference?

38:50 - How **diet and gut bacteria affect dopamine production**

45:30 - Martha’s **top microbiome tips for health & longevity**

51:20 - Where to find Martha’s **research, blogs, and probiotic products**

🚀 **Resources & Links:**

🔗 Learn more about Martha’s work: [The Biocollective] (https://www.thebiocollective.com/) [Biotiquest](https://biotiquest.com/)

🔗 Follow her blog on gut health & Parkinson’s: [Martha’s Quest](https://www.marthasquest.com/)

🔗 Check out **probiotic products** mentioned in the episode: [Sugar Shift](https://biotiquest.com/products/sugar-shift)

🔔 **Don’t forget to like, subscribe!** #Microbiome #GutHealth #Parkinsons #Probiotics #HealthPodcast #BrainHealth

Is Long COVID wreaking havoc on your nervous system? In episode 110 of The One Thing Podcast, Dr. Adam Rinde interviews Dr. Robert Groysman, an anesthesiologist (MD), and pioneer in treating dysautonomia (autonomic nervous system dysfunction) and post-viral illness. Discover groundbreaking therapies, including: * **Vagal Nerve Stimulation (VNS):** Learn how affordable, transcutaneous VNS can help regulate inflammation and calm your nervous system , * **Stellate Ganglion Blocks:** Understand how this procedure, initially used for PTSD, is now offering relief from Long COVID symptoms., * **The EAT Procedure:** Discover a novel Japanese therapy (epipharyngeal abrasive therapy) targeting the root causes of inflammation, even stubborn conditions like tinnitus and Eustachian tube dysfunction. Dr. Groysman shares his unique approach to treating Long COVID, focusing on four primary causes: dysautonomia, mitochondrial dysfunction, gut dysbiosis, and mast cell activation (histamine issues). He also discusses the importance of the vagus nerve in inflammation management and why standard treatments for POTS might not be enough to address the full scope of dysautonomia. **If you're struggling with Long COVID, chronic fatigue, brain fog, or other post-viral symptoms, this episode is a must-watch!**

0:00 - Intro: Long COVID, Dysautonomia, and the Autonomic Nervous System

1:07 - Introducing Dr. Robert Groysman and His Journey

3:24 - Dr. Groysman's Medical Background and Interest in Long COVID

5:03 - Stellate Ganglion Blocks for PTSD and Connection to Long COVID

7:20 - How Dysautonomia Drives Long COVID Inflammation

9:19 - The Four Primary Causes of Long COVID11:18 - Inflammatory Mediators and Brain Fog

12:25 - Defining Dysautonomia and the Role of the Vagus Nerve

14:28 - The Vagus Nerve and Its Anti-Inflammatory Pathway

16:43 - Vagal Nerve Stimulation as a Treatment for Inflammation

17:55 - Transcutaneous Vagal Nerve Stimulation (tVNS) Devices

19:16 - Accessing the Vagus Nerve Through the Ear

21:55 - How VNS Works in the Brainstem

23:40 - Vagal Nerve Dysfunction in Long COVID

24:29 - Anesthesiology Background and VNS Therapy

26:30 - Research Supporting Vagal Nerve Stimulation

27:25 - Ear vs. Cervical Vagus Nerve Stimulation

29:30 - Choosing the TENS 7000 for tVNS

31:28 - Real-World Patient Response to tVNS

32:45 - Measuring Dysautonomia: Heart Rate Variability and Resting Heart Rate

34:15 - Orthostatic Readings and POTS

35:38 - Pre-Selecting Patients for Vagal Nerve Stimulation

36:50 - VNS as part of an Integrative Treatment Program

38:35 - Dr. Groysman's Four-Pillar Approach to Long COVID

41:10 - Long COVID Centers and Lack of Root Cause Treatments

42:48 - Introducing the EAT Procedure (Epipharyngeal Abrasive Therapy)

45:18 - How the EAT Procedure Cleans Inflamed Nasal Tissue

47:00 - Diagnosing the Need for the EAT Procedure

47:55 - EAT Procedure Success Stories: Voice Changes

49:10 - The Connection Between Vocal Cord Problems and the Vagus Nerve

50:15 - LPR (Laryngopharyngeal Reflux) and Potential Connection to Vagus Nerve

51:19 - Dr. Groysman's Practice, Telehealth and Treatment Approach

53:03 - Unique Combination of EAT and Stellate Ganglion Blocks

53:37 - Final Thoughts on Vagal Nerve Stimulation & Education

55:01 - Outro and Podcast Info

Links: Show notes: https://onethingpod.com/110-vagal-stim Dr. Groysman's facebook page https://www.facebook.com/groups/longcovidsgb Dr. Groysman's clinic https://covidinstitute.org/about-dr-groysman/ **#LongCOVID #Dysautonomia #VagalNerveStimulation #VNS #StellateGanglionBlock #EATProcedure #PostViralSyndrome #ChronicFatigue #BrainFog #Inflammation #TENS7000 #AutonomicNervousSystem #RobertGryan #DrAdamRindy #FunctionalMedicine #RootCauseTreatment**