Year in Review: Clinical Investigator Perspectives on the Most Relevant New Datasets and Advances in Prostate Cancer | Faculty Presentation 2: Other Available and Emerging Therapeutic Approaches — Emmanuel S Antonarakis, MD

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Year in Review: Clinical Investigator Perspectives on the Most Relevant New Datasets and Advances in Prostate Cancer | Faculty Presentation 1: Optimizing the Role of Hormonal Therapy in the Care of Patients with Prostate Cancer (PC) — Professor Karim Fizazi, MD, PhD

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Featuring perspectives from Dr Christopher Flower and Dr Krish Patel, including the following topics:

• Role of Chimeric Antigen Receptor T-Cell Therapy and Bispecific Antibodies for Non-Hodgkin Lymphoma (NHL) — Dr Patel (0:00)
• Other Available and Emerging Novel Therapies for NHL — Dr Flowers (22:07)

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Featuring perspectives from Dr David M O’Malley and Dr Brian M Slomovitz, including the following topics:

• Ovarian Cancer; HER2-Directed Therapy for Advanced Gynecologic Cancers — Dr O'Malley (0:00)
• Endometrial Cancer and Cervical Cancer — Dr Slomovitz (23:38)

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Featuring an interview with Dr John P Leonard, including the following topics:

• First-line therapy for diffuse large B-cell lymphoma (DLBCL) with polatuzumab vedotin and R-CHP; impact of DLBCL cell of origin (0:00)
• Epcoritamab, glofitamab and other bispecific antibodies as initial therapy for large B-cell lymphoma (9:27)
• Sequencing chimeric antigen receptor T-cell therapy and bispecific antibodies for patients with relapsed/refractory (R/R) DLBCL (12:30)
• Approved and investigational bispecific antibodies for the treatment of DLBCL (15:24)
• Practical considerations for the administration of mosunetuzumab (22:03)
• Tafasitamab combined with lenalidomide/rituximab as second-line treatment for follicular lymphoma (FL); third- and later-line therapy options (24:33)
• Activity of Bruton tyrosine kinase inhibitors in FL and other non-Hodgkin lymphomas (31:27)
• Risk of infection for patients receiving bispecific antibodies (33:23)
• Chemotherapy-free regimens for the treatment of mantle cell lymphoma (MCL) (36:21)
• Current role of transplant in the treatment algorithm for MCL; potential integration of bispecific antibodies into therapy for R/R disease (41:23)
• Myths and misperceptions about the management of DLBCL, FL and MCL (47:29)

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Featuring a slide presentation and related discussion from Dr John P Leonard, including the following topics:

• Five-year analysis of the POLARIX trial of polatuzumab vedotin with R-CHP for previously untreated diffuse large B-cell lymphoma (0:00)
• Epcoritamab, glofitamab and other bispecific antibodies for large B-cell lymphoma (5:33)
• Circulating tumor DNA as an early outcome predictor in patients with large B-cell lymphoma receiving second-line lisocabtagene maraleucel in the TRANSFORM study (16:44)
• The bispecific antibodies mosunetuzumab and odronextamab as initial therapy for follicular lymphoma (FL) (19:27)
• The Phase III inMIND trial of tafasitamab in combination with lenalidomide/rituximab for recurrent FL (22:58)
• Updated results from studies of bispecific antibodies and chimeric antigen receptor T-cell therapy for relapsed/refractory FL (24:58)
• Updates from the Phase III TRIANGLE and ECOG-ACRIN EA4151 trials on the role of autologous stem cell transplant in the treatment of previously untreated mantle cell lymphoma (MCL) (27:48)
• Novel treatment approaches with Bruton tyrosine kinase inhibitors for patients with newly diagnosed MCL (30:53)

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Featuring perspectives from Dr Rahul Aggarwal, Ms Monica Averia, Ms Kathleen D Burns and Dr William K Oh, including the following topics:

• Introduction: Overview of Prostate Cancer (0:00)
• Recent Advances in the Treatment of Nonmetastatic Prostate Cancer (8:36)
• Treatment Approaches for Metastatic Hormone-Sensitive Prostate Cancer (30:01)
• Current Role of PARP Inhibitors in Metastatic Castration-Resistant Prostate Cancer (mCRPC) (47:41)
• Current and Future Role of Radiopharmaceuticals in mCRPC (1:09:57)

NCPD information and select publications

Featuring perspectives from Prof Rebecca A Dent and Dr Nancy U Lin, including the following topics:

• Introduction: A New Paradigm for Triple-Positive Breast Cancer? (0:00)
• CDK4/6 Inhibitors for HR-Positive, HER2-Negative Breast Cancer (10:06)
• Oral Selective Estrogen Receptor Degraders for HR-Positive, HER2-Negative Breast Cancer (21:17)
• Treatment of PIK3CA/PTEN/AKT-Mutated Breast Cancer (31:34)
• Antibody-Drug Conjugates (ADCs) for HR-Positive, HER2-Negative Breast Cancer (38:41)
• ADCs for HER2-Positive Breast Cancer (46:30)
• HER2-Targeting Tyrosine Kinase Inhibitors for HER2-Positive Breast Cancer (53:26)
• ADCs for Advanced Triple-Negative Breast Cancer (58:29)

CME information and select publications