In this episode, we unpack some fascinating insights from an NBC News article that highlights why most people stop using Wegovy after two years. Dr. Weiner shares his thoughts, explaining that a lack of access due to shortages, high costs, and insurance coverage issues are significant reasons why people discontinue these medications. The Pharmacy Benefit Managers (PBMs) who released the data might also have an agenda since they are not keen on covering expensive weight loss medications. Dr. Weiner believes that many people would continue using Wegovy if they had consistent access without these barriers.

We also hear Martin's inspiring weight loss journey. Initially struggling with his weight from a young age, he tried every fad diet before opting for weight loss surgery. Martin shares his experience with the lap band surgery in 2009, which didn’t work out as planned. He eventually transitioned to a gastric bypass after his wake-up call, realizing that he wanted to lead a healthier life for his family. Through a combination of gastric bypass, GLP-1 medications like Mounjaro, and the 10-to-1 protein rule, Martin achieved a significant weight loss. His story underlines the importance of finding a personal "why" and using it as motivation to make lasting lifestyle changes​​.

Dr. Weiner discusses the heritability of weight loss response to gastric bypass surgery, emphasizing that genetic factors often play a significant role in the success of such procedures. He cites a study showing that the genetic relationship between first-degree relatives had a more substantial impact on weight loss success after surgery than merely living together. This highlights the potential genetic influence on how individuals respond to both surgery and weight loss medications​.

We also dive into practical advice on reaching protein goals post-surgery. For those struggling with limited food volume, we recommend strategies like fortifying meals with protein powders and choosing nutrient-dense options like Greek yogurt or smoothies to meet protein targets without consuming large quantities of food. Achieving these protein goals can help speed up weight loss and break through plateaus​​.

Overall, this episode covers the complexities of weight loss, from understanding the barriers to medication adherence to navigating genetic influences and personalizing nutrition strategies.