When Sarah Jepson’s mother Annie dies, Sarah is left with her little brother Tommy to care for. Alone in the world, the two of them must make a life for themselves in the wake of the terrible upbringing they have endured. But when Tommy is struck down by illness, Sarah’s new life collapses. Lost in grief, she turns to the handsome Roger to save her – only to find that he is not who he seems....

When sixteen-year-old Sally is evacuated to the English south coast, she is terrified by what lies ahead of her. All she knows are the sights and sounds of London's East End – but Sally swallows her tears as they leave the familiar landmarks behind, knowing that she has to be a Grown-Up Girl and play mother to her six-year-old brother Ernie. Playing mother is nothing new for Sally – their real mother Florrie, a good-time girl, hasn't even come to the station to wave them off and Ernie, crippled at an early age by polio, is used to depending on his older sister.

Rita and Rosie Stevens are only nine and five years old when their widowed mother marries a violent bully called Jimmy Randall and has a baby boy by him. Under pressure from her new husband, she is persuaded to send the girls to an orphanage, not knowing that the papers she has signed will entitle them to do what they like with the children. And it is not long before the powers that be decide to send a consignment of orphans to their sister institution in Australia. Among them - without their family's consent or knowledge - are Rita and Rosie.

Adam adores Emily. Emily thinks Adam’s perfect, the man she thought she’d never meet. Emily chose Adam, but she didn’t choose his mother, Pammie. There’s nothing a mother wouldn’t do for her son, and now Emily is about to find out just how far Pammie will go to get what she wants: Emily gone forever.

You think you know the truth about the people you love. But one discovery can change everything.... Eight-year-old Billy goes missing one day, out flying his kite with his sister Rose. Two days later he is found dead. Sixteen years on, Rose still blames herself for Billy's death. How could she have failed to protect her little brother? Rose has never fully recovered from the trauma, and one of the few people she trusts is her neighbour Ronnie, who she has known all her life.

How far would you go to protect your family? Single dad Ben is doing his best to raise his children, with the help of his devoted mother, Judi. And then Ben meets Amber. Everyone thinks this is a perfect match for Ben, but Judi isn't so sure.... There's just something about Amber that doesn't add up. Ben can't see why his mother dislikes his new girlfriend. And Amber doesn't want Judi anywhere near her new family. Amber just wants Ben and the children.

West Yorkshire, 1926. After completing her training in Steeple Street, Agnes is looking forward to making her mark as the village's first district nurse, confident she can make a difference in the locals' lives. But when she arrives, she's treated with suspicion, labelled just another servant of the wealthy mine owners. The locals would much rather place their trust in the resident healer, Nella Black.

Susie did something that she knows she will always regret: giving her baby son up for adoption, to keep her infidelity secret from her family. Louise, Susie's daughter, feels the effects of that decision echoing down through the years - her mother has always been difficult, too strict with her but not strict enough with her sister, Grace, who is wild and out of control. And Danny, Susie's husband, adores her but has always sensed something wrong at the heart of their marriage.

Anna Cole grew up poor, but her mother's love made her feel rich every day. Then her mother died, and Anna was sent to a care home. As a teenager, Anna vowed that one day she would have children of her own and create the happy, noisy family life she always craved. Then, one day, Anna meets Theo Montgomery in a lift. Theo has kind eyes but a sad past. His family were rich, but his childhood was full of neglect. Theo can't imagine bringing a child into this cruel world, but he does want a soul mate. Someone to love him unconditionally; someone with whom he can share his family's wealth.

1943: Europe is at war - but neutral Ireland is isolated from the storm. In a sleepy coastal village south of Dublin, eighteen-year-old Aileen Sweeney meets soldier Niall O’Rourke at a dance, and the spark between them soon ignites a powerful love. But when Niall makes a life-changing and contentious decision, Aileen’s hopes and dreams fall apart. In an instant Niall is transformed from dashing suitor to social outcast, and the fallout leaves each of them navigating the consequences alone. Putting her innocence behind her, Aileen must make her own tough choices.

Three very different girls sign up as trainee nurses at a big London teaching hospital in 1934. Dora leaves her overcrowded, squalid working-class home for a better life. But has she got what it takes to keep up with other, better-educated girls? And will her hated stepfather ever let her go? Helen is born for the job; her brother is a doctor, her all-powerful mother a hospital trustee. But will Helen’s secret misery be her downfall? An aristocratic rebel, Millie’s carefree attitude will find her up in front of Matron again and again. Will she ever care enough to make a nurse? Or will she go back to the glamorous life she was born to?

Welcome to the district nurses' home on Steeple Street, where everyone has a secret.... Ambitious young nurse Agnes Sheridan had a promising future ahead of her until a tragic mistake cost her the love and respect of everyone around her. Now she has come to Leeds for a fresh start as a trainee district nurse. But Agnes finds herself facing unexpected challenges as she is assigned to Quarry Hill, one of the city's most notorious slums.

In the midst of the Second World War, Eva receives the devastating news that her husband is missing and presumed dead. Neither wife nor widow, she lives in a numb state of limbo until, in the heat of an English summer, she meets Bill, a black American GI. Despite their vastly different backgrounds, neither can deny the love that overcomes them in the frantic weeks that follow, when every day could be their last.

Liverpool, 1940. When her childhood sweetheart, Johnny, is killed in action, Maxine Grey loses more than her husband - she loses her best friend. Desperate to make a difference in this awful war, Maxine takes a nursing job at London’s St Thomas’ hospital. She takes comfort in the attentions of a handsome surgeon, but Edwin Blake isn’t all he seems. And as the Blitz descends on the capital, Maxine faces more heartache. When she returns to Liverpool, she harbours a secret.

Liverpool, 1941. Troubled by a dark family history and the pain of seeing her country torn apart by war, young June Lavender finds new hope when she takes a job at the Dr Barnardo's children's home. There she meets Lizzie McRae, a little girl who is the spitting image of June's sister, who died tragically years before. Against the matron's wishes, the two girls form an unexpected bond as June tries to get the traumatised orphan to speak.