Mack Anders will do anything for his wife, Daisy. Even die. With the woman he loves fading away from Alzheimer’s, Mack fakes his own passing. The insurance makes certain that Daisy will be taken care of with dignity and comfort until the end. In a lonesome cabin in the Wyoming wilderness, he lives off the grid with nothing but thoughts of the past to keep him company and the belief that Daisy is better off without him.

Freakishly smart. That’s the unwelcome box Ru Evans is put into for life. After all, she taught herself Euclidean geometry at age seven, has an eidetic memory, and is about to enter college at thirteen years old. Boarding at a house near campus 150 miles from home, Ru meets seventeen-year-old Gabriel, an outsider himself who, like Ru, has trouble making friends—until they form a fast sibling-like bond. Finding a relatable someone in the world to talk to is a first for both of them.

When her nineteen-year marriage ends, stay-at-home mom Effie Baker takes the first step into her new life with an extreme makeover. She assumes she’ll wake up with a renewed sense of confidence, not a vision of country music icon Patsy Cline telling her she needs to “set things right.” But like everything else lately, the last thing Effie expected is exactly what she gets.

Crushed by guilt over the car accident that killed her father and sister, and torn apart by her mother’s resentment, Darcy Goodridge fled her family estate eight years ago and hasn’t looked back. Now an unexpected phone call threatens to upend what little serenity she’s found. Her nephew, Emerson, who was just a baby when his mother died, has gone missing. Darcy must return home and face her past in order to save him.

On the run from her abusive husband, Kyra Smith hits the road. Destination unknown. With a neglected dog she rescued in tow, she lands in the peaceful California town of Gold Creek and is immediately befriended by an openhearted group of women called the Tattooed Ladies Club. They’re there for Kyra—and for each other.

Former Broadway dancer and current agoraphobic Billy Shine has not set foot outside his apartment in almost a decade. He has glimpsed his neighbors--beautiful manicurist Rayleen, lonely old Ms. Hinman, bigoted and angry Mr. Lafferty, kind-hearted Felipe, and nine-year-old Grace and her former addict mother, Eileen. But most of them have never seen Billy. Not until Grace begins to sit outside on the building's front stoop for hours every day, inches from Billy's patio.

Faye Martin never expected her husband to abandon her and their three children...or that she'd have to struggle every day to make ends meet. So when her 4-year-old daughter is discovered through a YouTube video and offered a starring role on a television series, it seems like her prayers have been answered. But when the reality of their new life settles in, Faye realizes that fame and fortune don't come without a price.

Midwife Patience Murphy has a gift: a talent for escorting mothers through the challenges of bringing children into the world. Working in the hardscrabble conditions of Appalachia during the Depression, Patience takes the jobs that no one else wants, helping those most in need - and least likely to pay. She knows a successful midwifery practice must be built on a foundation of openness and trust - but the secrets Patience is keeping are far too intimate and fragile for her to ever let anyone in.

Hayden Reese has a bad habit of breaking people's jaws. Granted, he only breaks jaws that deserved some breaking, but he's starting a whole new feud, with the husband of his lover—and this time, it may cost him his life. Hayden's life has never been easy. His father tormented him, his kid brother got all the approval, and he made a fatal mistake that he's never been able to forgive himself for making. But when Hayden's future is shattered by his bad choices, he has to redeem himself in the eyes of his long-estranged daughter Allegra.

After a tragic accident claims the life of one of her children, Marie Egide is desperate to carve out a fresh start for her family. With her husband and their three surviving children, Marie travels to New Hampshire, where she plans to sell a family estate and then, just maybe, they’ll be able to heal from their grief. Marie’s plans are thwarted when she realizes a war veteran known by locals as “the river witch” is living in a cabin on the property, which she claims was a gift from Marie’s grandfather. If Davina refuses to move on, Marie won’t be able to either.

Seventeen-year-old Ethan Underwood is totally unprepared to search for his father in the Blythe River National Wilderness. Not only is he small, scrawny, and skittish but he's barely speaking to the man after a traumatic betrayal. Yet when his father vanishes from their remote cabin and rangers abandon the rescue mission, suddenly it's up to Ethan to keep looking. Angry or not, he's his father's only hope.

Lewis Madigan is young, gay, out of work, and getting antsy when he’s roped into providing end-of-life care for his insufferable homophobic neighbor, Chester Wheeler. Lewis doesn’t need the aggravation, just the money. The only requirements: run errands, be on call, and put up with a miserable old churl no one else in Buffalo can bear. After exchanging barbs, bickering, baiting, and pushing buttons, Chester hits Lewis with the big ask. Lewis can’t say no to a dying wish.

Ruth and her little brother, Aubrey, are just teenagers when their older brother ships off to Iraq. When Joseph returns, uninjured, only three and a half months later, Ruth is happy he is safe but also deeply worried. How can it be that her courageous big brother has been dishonorably discharged for refusing to go out on duty? Aubrey can't believe that his hero doesn't have very good reasons.

1902: Upon arriving in Kenworthy, California, mail-order bride Juniper Cohen is met by the pounding of the gold mine, an untamable landscape, and her greatest surprise of all: the kind and charming man who awaits her. But when the mine proves empty of profit, and when Juniper’s husband, John, vanishes, Juniper is left to fend for herself and her young daughter in the dying town that is now her home.

Lochiel Ogle was born with a red-wine birthmark—and it put her life in jeopardy from the moment she entered the world. Mountain folks called it "the mark of the devil," and for all the evil that has plagued her nineteen-year existence, Lochiel is ready to believe that is true. And the evil surely took control of the mind of the boy who stole her as an infant, bringing her home for his mother to raise.

When her nineteen-year marriage ends, stay-at-home mom Effie Baker takes the first step into her new life with an extreme makeover. She assumes she’ll wake up with a renewed sense of confidence, not a vision of country music icon Patsy Cline telling her she needs to “set things right.” But like everything else lately, the last thing Effie expected is exactly what she gets.

On the run from her abusive husband, Kyra Smith hits the road. Destination unknown. With a neglected dog she rescued in tow, she lands in the peaceful California town of Gold Creek and is immediately befriended by an openhearted group of women called the Tattooed Ladies Club. They’re there for Kyra—and for each other.

If Lark and Mikki didn’t have each other, they’d have nothing in this miserable town. So the best friends stick together, working night shift at the highway travel stop, going nowhere fast. Until a stranger drops in, heading for Florida, and Mikki impulsively leaves with him, never to be seen again. Eight years later, Lark is finally getting her life back together for the sake of her young daughter and Mikki’s lovably prickly grandma, who can no longer care for herself. People have almost stopped blaming Lark for Mikki’s disappearance, and she’s engaged to the nicest guy on highway patrol.

Maggie Blount, divorced mother of two and California physician, puts her private practice on hold when disaster strikes. Doctors on Wheels takes her and Alex—Maggie’s professional and romantic partner—wherever they’re needed. After rolling into rural Louisiana in the wake of a category five hurricane, Maggie immediately bonds with two sisters and their puppy, all orphaned by the storm. It’s enough to break Maggie’s heart, and she’s not leaving them behind.

Mack Anders will do anything for his wife, Daisy. Even die. With the woman he loves fading away from Alzheimer’s, Mack fakes his own passing. The insurance makes certain that Daisy will be taken care of with dignity and comfort until the end. In a lonesome cabin in the Wyoming wilderness, he lives off the grid with nothing but thoughts of the past to keep him company and the belief that Daisy is better off without him.

Biographer Ellie Connor is in Gideon, Texas, to research blues singer Mabel Beauvais who, on the verge of fame, mysteriously disappeared more than forty years ago. Gideon holds another mystery for Ellie. It’s the truth about her parents—a restless mother who died young and a father she never knew. They are an unsettled piece of Ellie’s own past. Somewhere in this town is the answer to both of her quests.

Months after her mother passes away, artist Tillie Morrisey sees a painting in a gallery that leaves her inexplicably lightheaded and unsteady. When a handsome stranger comes to her aid, their connection is so immediate it seems fated, though Liam is only visiting for a few days. Working on her own art has always been a refuge, but after discovering a document among her mother’s belongings that suggests Tillie’s life has been a lie, she begins to suffer from a series of fugue states, with memories surfacing that she isn’t even sure are her own.

Hayden Reese has a bad habit of breaking people's jaws. Granted, he only breaks jaws that deserved some breaking, but he's starting a whole new feud, with the husband of his lover—and this time, it may cost him his life. Hayden's life has never been easy. His father tormented him, his kid brother got all the approval, and he made a fatal mistake that he's never been able to forgive himself for making. But when Hayden's future is shattered by his bad choices, he has to redeem himself in the eyes of his long-estranged daughter Allegra.

On a tiny island off Paradiso, Florida, in 1970, neighbors gather to toast two new arrivals: shy Catherine and her taciturn husband, Dr. Frank Overbrook, who is taking over an old friend’s medical practice. It’s an intimate welcoming for the newlyweds, who have abandoned city life for swaying palms and an ocean breeze. But the morning after is anything but peaceful when Frank is found dead on the beach.

When Chase Stone’s estranged father dies, leaving his multibillion-dollar business to his children, no one is more surprised than him. Growing up outside of the high-stakes world filled with human vultures, Chase and his sister, Alex, are less than enthusiastic about stepping into their father’s shoes. That is until they learn of a half brother they didn’t know existed, and must find to share their inheritance with.

Lewis Madigan is young, gay, out of work, and getting antsy when he’s roped into providing end-of-life care for his insufferable homophobic neighbor, Chester Wheeler. Lewis doesn’t need the aggravation, just the money. The only requirements: run errands, be on call, and put up with a miserable old churl no one else in Buffalo can bear. After exchanging barbs, bickering, baiting, and pushing buttons, Chester hits Lewis with the big ask. Lewis can’t say no to a dying wish.

For social worker Mallory Ward, working with at-risk youth is a calling. But when one of her clients is tragically killed, she finds herself at a crossroads. Despite long-held resentments toward her distant mother, Mallory retreats to her childhood home on the Rhode Island coast to contemplate her future. Instead, she’s confronted by her past, not only in the renewed tensions with her mother but in the unexpected appearance of a familiar face—and the wrenching losses that drove her away a decade ago.

It’s been eight years since a tragic accident changed Mo Kaminski’s and Chloe Miller’s lives forever. Now in their midtwenties, they’re sharing an apartment in San Francisco and navigating the normal challenges of early adulthood. Along with their roommate, Hazel, they are making their marks on the world - Mo revolutionizing the news with her media start-up, Hazel using her big brain to anticipate the future, and Chloe rescuing abandoned strays in the city.

Tig Costello has arrived in Darren, Kentucky, commissioned to paint a portrait honoring her grandfather Benjamin. His contributions to the rural Appalachian town and his unimpeachable war service have made him a local hero. But to Tig, he’s a relative stranger. To find out more about him, Tig wants to talk to the person who knew her grandfather best: Eloise Price, the woman who murdered him fifty years ago.

Ruth Winters is retired, widowed, and resigned to spending the rest of her life alone in her suburban home. She likes her routine and uses it to avoid having to spend time with other people. She probably wouldn’t call herself fulfilled, but it’s too late now to go chasing happiness. Then three things happen at once: a beloved niece makes a big announcement, an old flame reaches out, and her estranged sister receives life-changing news.