For four years, Iris Massey worked side by side with PR maven Smith Simonyi, helping clients perfect their brands. But Iris has died, taken by terminal illness at only 33. Adrift without his friend and colleague, Smith is surprised to discover that in her last six months, Iris created a blog filled with sharp and often funny musings on the end of a life not quite fulfilled. She also made one final request: for Smith to get her posts published as a book

Carter University: “The Harvard of the South.” Annie Stoddard was the smartest girl in her small public high school in Georgia, but now that she’s at Carter, it feels like she’s got “Scholarship Student” written on her forehead. Bea Powers put aside misgivings about attending college in the South as a biracial student to take part in Carter’s Justice Scholars program. Their lives - and barista Stayja York's - intersect unexpectedly when Annie accuses fourth-year student Tyler Brand of sexual assault, and Bea is assigned as Tyler’s student advocate.

Mia and Lorrie Ann are lifelong friends: hard-hearted Mia and untouchably beautiful, kind Lorrie Ann. While Mia struggles with a mother who drinks, a pregnancy at 15, and younger brothers she loves but can’t quite be good to, Lorrie Ann is luminous, surrounded by her close-knit family, immune to the mistakes that mar her best friend’s life. Then a sudden loss catapults Lorrie Ann into tragedy: things fall apart, and then fall further - and there is nothing Mia can do to help.

Natural-born healer Emma Starling once had big plans for her life, but she’s lost her way. A medical school dropout, she’s come back to small-town Everton, New Hampshire, to care for her father, who is dying from a mysterious brain disease. Clive Starling has been hallucinating small animals, as well as having visions of the ghost of a long-dead naturalist, Ernest Harold Baynes, once known for letting wild animals live in his house. This ghost has been giving Clive some ideas on how to spend his final days.

It’s 2011, and Samuel Andresen-Anderson—college professor, stalled writer—has a Nix of his own: his mother, Faye. He hasn’t seen her in decades, not since she abandoned the family when he was a boy. Now she’s re-appeared, having committed an absurd crime that electrifies the nightly news, beguiles the internet, and inflames a politically divided country. The media paints Faye as a radical hippie with a sordid past, but as far as Samuel knows, his mother was an ordinary girl who married her high-school sweetheart.

In 1985, Yale Tishman, the development director for an art gallery in Chicago, is about to pull off an amazing coup, bringing in an extraordinary collection of 1920s paintings as a gift to the gallery. Yet as his career begins to flourish, the carnage of the AIDS epidemic grows around him. One by one, his friends are dying and after his friend Nico's funeral, the virus circles closer and closer to Yale himself. Soon the only person he has left is Fiona, Nico's little sister.

The first story Selma Blair Beitner ever heard about herself is that she was a mean, mean baby. With her mouth pulled in a perpetual snarl and a head so furry it had to be rubbed to make way for her forehead, Selma spent years living up to her terrible reputation: biting her sisters, lying spontaneously, getting drunk from Passover wine at the age of seven, and behaving dramatically so that she would be the center of attention. In a memoir that is as wildly funny as it is emotionally shattering, Blair tells the captivating story of growing up and finding her truth.

The summer that Nixon resigns, six teenagers at a summer camp for the arts become inseparable. Decades later the bond remains powerful, but so much else has changed. In The Interestings, Wolitzer follows these characters from the height of youth through middle age, as their talents, fortunes, and degrees of satisfaction diverge. The kind of creativity that is rewarded at age 15 is not always enough to propel someone through life at age 30; not everyone can sustain, in adulthood, what seemed so special in adolescence.

Marnie MacGraw wants an ordinary life - a husband, kids, and a minivan in the suburbs. Now that she’s marrying the man of her dreams, she’s sure this is the life she’ll get. Then Marnie meets Blix Holliday, her fiancé’s irascible matchmaking great-aunt who’s dying, and everything changes - just as Blix told her it would. When her marriage ends after two miserable weeks, Marnie is understandably shocked.

When Lauren and Ryan’s marriage reaches the breaking point, they come up with an unconventional plan. They decide to take a year off in the hopes of finding a way to fall in love again. One year apart, and only one rule: they cannot contact each other. Aside from that, anything goes. Lauren embarks on a journey of self-discovery, quickly finding that her friends and family have their own ideas about the meaning of marriage. These influences, as well as her own healing process and the challenges of living apart from Ryan, begin to change Lauren’s ideas about monogamy and marriage.

To be admired by someone we admire - we all yearn for this: the private, electrifying pleasure of being singled out by someone of esteem. But sometimes it can also mean entry to a new kind of life, a bigger world. Greer Kadetsky is a shy college freshman when she meets the woman she hopes will change her life. Faith Frank, dazzlingly persuasive and elegant at 63, has been a central pillar of the women’s movement for decades, a figure who inspires others to influence the world.

Twentysomething Nora McInerny Purmort bounced from boyfriend to boyfriend and job to job. Then she met Aaron, a charismatic art director and her kindred spirit. They made mixtapes (and pancakes) into the wee hours of the morning. They finished each other's sentences. They just knew. When Aaron was diagnosed with a rare brain cancer, they refused to let it limit their love. They got engaged on Aaron's hospital bed and married after his first surgery. They had a baby when he was on chemo.

Parker Santé hasn't spoken a word in five years. While his classmates plan for bright futures, he skips school to hang out in hotels, killing time by watching the guests. But when he meets a silver-haired girl named Zelda Toth, a girl who claims to be quite a bit older than she looks, he'll discover there just might be a few things left worth living for.

Kenya Curtis is only eight years old, but she knows that she's different, even if she can't put her finger on how or why. It's not because she's black - most of the other students in the fourth-grade class at her West Philadelphia elementary school are, too. Maybe it's because she calls her father - a housepainter-slash-philosopher - "Baba" or because her parents' friends gather to pour out libations "from the Creator, for the Martyrs" and discuss "the community".

An extraordinary literary work, Dear Mr. You renders the singular arc of a woman's life through letters Mary-Louise Parker composes to the men, real and hypothetical, who have informed the person she is today. Beginning with the grandfather she never knew, the letters range from a missive to the beloved priest from her childhood to remembrances of former lovers to an homage to a firefighter she encountered to a heartfelt communication with the uncle of the infant daughter she adopted.