At the center of Home Again is Madelaine - a brilliant cardiologist, a loving mother, a tender friend, and a woman full of self-doubt. It is also the story of her confused and angry daughter, Lina, and of the two very different men Madelaine loves: Francis, a priest searching for his faith, and Angel, a talented but cynical man with a broken heart. When tragedy suddenly brings them all together, they must learn to forgive the betrayals of the past and find the courage to love again.

The Grey sisters had only each other when their mother died years ago. Their father provided for them physically on Water's Edge, the ranch that had been in their family for three generations, each of them however, longed for their father's love.

Thirty-four-year-old Ruby Bridge is a not-too-successful comedienne who uses her mother, a nationally-syndicated "moral and spiritual counselor" as the main fodder for her cynical, rather bitter humor. Her mother Nora, long divorced from Ruby's father, is a woman whose past is just about to catch up with her - in the form of blackmail by a former lover.

In the turbulent summer of 1974, Kate Mularkey has accepted her place at the bottom of the eighth-grade social food chain. Then, to her amazement, the "coolest girl in the world" moves in across the street and wants to be her friend. Tully Hart seems to have it all - beauty, brains, ambition. On the surface they are as opposite as two people can be: Kate, doomed to be forever uncool, with a loving family who mortifies her at every turn.

For 18 years, Jude Farraday has put her children’s needs above her own, and it shows - her twins, Mia and Zach, are bright and happy teenagers. When Lexi Baill moves into their small, close-knit community, no one is more welcoming than Jude. Lexi, a former foster child with a dark past, quickly becomes Mia’s best friend. Then Zach falls in love with Lexi and the three become inseparable. Jude does everything to keep her kids on track for college and out of harm’s way. It has always been easy - until senior year of high school. Suddenly she is at a loss.