William Waters grew up in a house silenced by tragedy, where his parents could hardly bear to look at him, much less love him—so when he meets the spirited and ambitious Julia Padavano in his freshman year of college, it’s as if the world has lit up around him. With Julia comes her family, as she and her three sisters are inseparable: Sylvie, the family’s dreamer, is happiest with her nose in a book; Cecelia is a free-spirited artist; and Emeline patiently takes care of them all.

Chika Jeune was born three days before the devastating earthquake that decimated Haiti in 2010. She spent her infancy in a landscape of extreme poverty, and when her mother died giving birth to a baby brother, Chika was brought to The Have Faith Haiti Orphanage that Albom operates in Port Au Prince. With no children of their own, the 40-plus children who live, play, and go to school at the orphanage have become family to Mitch and his wife, Janine. But at age five, Chika is suddenly diagnosed with something a doctor there says "no one in Haiti can help you with."

Fans know her as the spoiled, rich cheerleader Lyla Garrity on Friday Night Lights or as the affluent, mysterious Samantha on the HBO megahit Euphoria. But as revealed for the first time in this book, Minka Kelly’s life has been anything but easy. Raised by a single mother who worked as a stripper and struggled with addiction, Minka spent years waking up in strange apartments as she and her mom bounced around the country, relying on friends and relatives to take them in. Now an established actress and philanthropist, Minka takes this next step in her career as a writer.

As an undergraduate, Michele Filgate started writing an essay about being abused by her stepfather. It took her more than a decade to realize that she was actually trying to write about how this affected her relationship with her mother. When it was finally published, the essay went viral, shared on social media by Anne Lamott, Rebecca Solnit, and many others. This gave Filgate an idea, and the resulting anthology offers a candid look at our relationships with our mothers.

Growing up in the 1960s in the suburbs of Chicago, Meg Kissinger’s family seemed to live a charmed life. With eight kids and two loving parents, the Kissingers radiated a warm, boisterous energy. Whether they were spending summer days on the shores of Lake Michigan, barreling down the ski slopes, or navigating the trials of their Catholic school, the Kissingers always knew how to live large and play hard. But behind closed doors, a harsher reality was unfolding.

Gifty is a sixth-year PhD candidate in neuroscience at the Stanford University School of Medicine studying reward-seeking behavior in mice and the neural circuits of depression and addiction. Her brother, Nana, was a gifted high school athlete who died of a heroin overdose after an ankle injury left him hooked on OxyContin. Her suicidal mother is living in her bed. Gifty is determined to discover the scientific basis for the suffering she sees all around her.

Alice Carrière tells the story of her unconventional upbringing in Greenwich Village as the daughter of a remote mother, the renowned artist Jennifer Bartlett, and a charismatic father, European actor Mathieu Carrière. From an early age, Alice is forced to navigate her mother’s recovered memories of ritualized sexual abuse, which she turns into art, and her father’s confusing attentions—her childhood is spent in an adult’s world, with little-to-no boundaries or supervision.

Laila Tarraf was the chief people officer for Peet’s Coffee and Tea, the iconic Berkeley coffee roaster, but she had a secret: She was failing in the most important relationships in her life. Yes, she was a strong and effective business leader, the successful daughter of immigrants, and the mother of a toddler, but she was disconnected from her own feelings ­and had little patience for those of others. All that changed, however, when three of the people most important to her - her husband, father, and mother - died in quick succession.

Through poverty, adolescence, and a fraught relationship with her mother, Ashley Ford wishes she could turn to her father for hope and encouragement. There are just a few problems: he’s in prison, and she doesn’t know what he did to end up there. She doesn’t know how to deal with the incessant worries that keep her up at night, or how to handle the changes in her body that draw unwanted attention from men. In her search for unconditional love, Ashley begins dating a boy her mother hates.

Actor Jim Beaver (Supernatural, Deadwood, Justified) and his wife Cecily Adams (Star Trek: Deep Space Nine's Moogie) were at the peaks of their careers and happily raising a beautiful two-year old daughter, Madeline. Then tragedy struck, not once, but twice. What followed was laid down by Jim in a moving, poignant, and uplifting journal of the following year, a year filled with heartbreak as well as enormous gifts and invaluable lessons, not just for Jim and his family but for listeners who traveled along with him on his journey.

Sharon Stone, one of the most renowned actresses in the world, suffered a massive stroke that cost her not only her health, but her career, family, fortune, and global fame. In The Beauty of Living Twice, Stone chronicles her efforts to rebuild her life and writes about her slow road back to wholeness and health. In a business that doesn’t accept failure, in a world where too many voices are silenced, Stone found the power to return, the courage to speak up, and the will to make a difference in the lives of men, women, and children around the globe.

"How did you get this number?" Those were the first words Jill Biden spoke to US senator Joe Biden when he called her out of the blue to ask her on a date. Growing up, Jill had wanted two things: a marriage like her parents' - strong, loving, and full of laughter - and a career. An early heartbreak had left her uncertain about love until she met Joe. But as they grew closer, Jill faced difficult questions: How would politics shape her family and professional life? And was she ready to become a mother to Joe's two young sons?

In an audiobook that is The Big Sick meets Dad Is Fat, Jeannie Gaffigan, writer/director/producer/accused supermom and wife of best-selling author/comedian Jim Gaffigan, writes with humor and heart about the pear-sized brain tumor she had removed, the toll it took on her enormous family, and the priceless lessons she learned along the way.

Snyder was eight years old when her mother died, and her distraught father thrust the family into an evangelical, cult-like existence halfway across the country. Furiously rebellious, she was expelled from school and home at age sixteen. Living out of her car and relying on strangers, Rachel found herself masquerading as an adult, talking her way into college, and eventually traveling the globe.

As an apple-cheeked bubbly child, Julianna was bestowed with the family nickname “Sunshine Girl”. Shuttled back and forth between her divorced parents, often on different continents, she quickly learned how to be of value to her eccentric mother and her absent father.

At a time when we mourn public figures and national tragedies with hashtags, where intimate posts about loss go viral and we receive automated birthday reminders for dead friends, it's clear we are navigating new terrain without a road map. Let's face it: Most of us have always had a difficult time talking about death and sharing our grief. We're awkward and uncertain; we avoid, ignore, or even deny feelings of sadness; we offer platitudes; we send sympathy bouquets whittled out of fruit.

When their only child was diagnosed with cystic fibrosis (CF) at the age of two, Maryanne O'Hara and her husband were told that Caitlin could live a long life or be dead in a matter of months. Thirty-one years later, Caitlin lost her battle with this devastating disease following an excruciating two-year wait on the transplant list and a last-minute race to locate a pair of healthy lungs. The sudden spiral of events left Maryanne in an existential crisis, searching to find an answer to the eternal question: Why we are here?

After almost 20 years together, Stella and Simon are starting to run into problems. An up-and-coming rock musician when they first met, Simon has been clinging to dreams of fame even as the possibility of it has grown dimmer, and now that his band might finally be on the brink again, he wants to go on the road, leaving Stella behind.

With a play opening on Broadway, and every reason to smile, Sarah Ruhl has just survived a high-risk pregnancy when she discovers the left side of her face is completely paralyzed. She is assured that 90 percent of Bell’s palsy patients experience a full recovery—like Ruhl’s own mother. But Sarah is in the unlucky ten percent. And for a woman, wife, mother, and artist working in theater, the paralysis and the disconnect between the interior and exterior brings significant and specific challenges.

Chika Jeune was born three days before the devastating earthquake that decimated Haiti in 2010. She spent her infancy in a landscape of extreme poverty, and when her mother died giving birth to a baby brother, Chika was brought to The Have Faith Haiti Orphanage that Albom operates in Port Au Prince. With no children of their own, the 40-plus children who live, play, and go to school at the orphanage have become family to Mitch and his wife, Janine. But at age five, Chika is suddenly diagnosed with something a doctor there says "no one in Haiti can help you with."

When Edward M. Hallowell was 11, a voice out of nowhere told him he should become a psychiatrist. A mental health professional of the time would have called this psychosis. But young Edward (Ned) took it in stride, despite not quite knowing what "psychiatrist" meant. With a psychotic father, an alcoholic mother, an abusive stepfather, and two so-called learning disabilities of his own, Ned was accustomed to unpredictable behaviour from those around him and to a mind he felt he couldn't always control.

In an idyllic Los Angeles neighborhood, where generations enjoy deep roots in old homes, the O’Rourke family fits right in. Miriam and Craig are both artists and their four children carry on the legacy. When their teenage son, Nick, is diagnosed with schizophrenia, a tumultuous decade ensues in which the family careens off the conventional course. Like the 10 Biblical plagues, they are hit by one catastrophe after another: violence, evictions, arrests, a suicide attempt, a near-drowning - even cancer and a brain tumor - play against the backdrop of a wild teenage bacchanal.

When her earliest childhood friend is diagnosed with a terminal illness, Becker sets off on a quest to immerse herself in what it means to be mortal. Can we live our lives more fully knowing some day we will die? With a keen eye toward that which makes life worth living, interfaith minister, mom, and perpetual seeker Barbara Becker recounts stories where life and death intersect in unexpected ways.

Using the written word as her witness statement, Jessica Willis Fisher tells a lacerating story of finding her voice after two decades of silence and an unforgettable story of risk and faith.

At only eight months old, identical twin sisters Ariel and Zan Henley were diagnosed with Crouzon syndrome — a rare condition where the bones in the head fuse prematurely. They were the first twins known to survive it. Growing up, Ariel and her sister endured numerous medical procedures to keep them alive. Doctors expanded the twins’ skulls and broke bones to make room for their growing organs. After each surgery, the sisters felt like strangers to each other, unable to recognize themselves in the mirror.