Mandera, im Nordosten Kenias: Die X1-Mandera-Pandemie breitet sich wie ein Flächenbrand aus - und ist kein biologisch-evolutionärer Zufall. Berlin: Ein Mann erwacht in seinem Zimmer im Concord Hotel und hat das Gedächtnis verloren. Mit ihm im Raum befinden sich die Leiche eines ihm unbekannten Mannes sowie ein Zettel mit einem seltsamen Code darauf. Atlanta: Die Ärztin Peyton Shaw wird von den kenianischen Behörden kontaktiert, um sich der mysteriösen Seuche anzunehmen. Sie findet heraus, dass ein ganzes Kartell geheimnisvoller Firmen, Institutionen und Organisationen die Pandemie mit einer finsteren Absicht steuert.

Dr. Tyson Klein is a quantum physicist who has dedicated his entire life to his research. At CERN, he analyses data generated by the Large Hadron Collider, the world's biggest and most powerful particle accelerator. Now, Ty believes he's found a pattern in its output. It looks like an organised data stream, being broadcast over what he calls a quantum radio. Could it be a signal from another universe? A message sent from the future? Or something else entirely?

After a mysterious global event known only as “The Change”, six strangers wake up in an underground research facility where they learn that they’re part of the Extinction Trials - a scientific experiment to restart the human race. But the Extinction Trials harbors a very big secret. And so does the world outside.

Dr. Sam Anderson is one of the most celebrated scientists in history. Ten years ago, he invented a device that changed the world forever. Now his life is about to be ripped apart—and his own creation may be to blame. One fateful morning, Sam discovers that his girlfriend has been murdered and that his daughter is accused of the crime. Sam believes she's innocent, but he can't prove it. There's only one thing he can do to save his daughter: confess to the crime. And so he does. But in the future, murderers aren't sent to prison. They're sent to the past.

In Atlanta, Dr. Peyton Shaw is awakened by the phone call she has dreaded for years. As the CDC's leading epidemiologist, she's among the first responders to outbreaks around the world. It's a lonely and dangerous job, but it's her life - and she's good at it. This time she may have met her match. In Kenya, an Ebola-like pathogen has infected two Americans. One lies at death's door. With the clock ticking, Peyton assembles her team and joins personnel from the Kenyan Ministry of Health and the WHO.

Two little girls stand with their heads bowed in my living room. I’m told they’re my granddaughters. Daisy is nine, and Alice seven. Daisy is the spitting image of her mother. This is the first time I’ve met them since my daughter and I fell out after she married that waste of space, Vince. They’ve come to live with me because their mother — my daughter — was murdered. In her own home while they slept close by. I think Vince killed her. But the police can’t prove it. I’ve always known he was no good. He treated my daughter like dirt. I said he’d cheat on her — but she wouldn’t listen.

Lowen Ashleigh is a struggling writer on the brink of financial ruin when she accepts the job offer of a lifetime. Jeremy Crawford, husband of best-selling author Verity Crawford, has hired Lowen to complete the remaining books in a successful series his injured wife is unable to finish. Lowen arrives at the Crawford home, ready to sort through years of Verity's notes and outlines, hoping to find enough material to get her started. What Lowen doesn't expect to uncover in the chaotic office is an unfinished autobiography Verity never intended for anyone to read.

Who is Audrey Hoedemaker? It's a question her sister Maureen has heard more times than she can count, and she doesn't know what the short answer would be. Little sister, troubled teen, backpacker, musical theatre coach, con artist, childcare worker. Murderer. A tragic, traumatic childhood casts a long shadow on the Hoedemaker sisters. Maureen has worked hard to move beyond the violence of the past and build a good, honest life for herself. Audrey, however, just can't seem to do the same, careening from one state of chaos to another.

After the killing of a prominent mob lawyer, NYPD homicide detectives Jacob Jackson and Caitlin Grimes start receive chilling, written “rules” for how to commit the perfect murder. "Rule number one for the perfect murder: Evidence is your enemy. Leave none behind." Jackson (Reid Scott) and Grimes (Cobie Smulders) race to find the killer, setting them on a collision course with the city’s crime underbelly, and a perpetrator who seems happy to toy with them. “Rule number two. No crimes of passion. The perfect murder is always business, never pleasure.”

Kidnappers grabbed Jenna in broad daylight, right in front of her children and their horrified classmates. Her family was issued an insane ransom demand: $25 million in cash and jewels, payable by the end of the school day, otherwise they’ll never see her again. As Jenna’s mother scrambles to gather the money, detectives Mo Butler and George Ortega follow the trail of the kidnappers, which will lead them through a sordid landscape of jealous lovers, broken dreamers, and twisted schemers. But every second counts, and there’s one thing Jenna Wade doesn’t have: very much time.